Important: Write all responses in complete sentences. The final worksheet should not exceed four total pages single-spaced (including the appendix of sequences), 1-inch margins, 12pt text size. Section 1 BioinformaticsPart 1: Find TASR238 (10 pts)In your own words, what information from the ‘Summary’ pane is relevant to our experiment?On what chromosome is TAS2R38located? Based on the diagram in the ‘Genomic context’ pane, what genes are located near TAS2R38?Click on the nearby genes; what are their functions (briefly)?Do any of the nearby genes share a similar function to TASR238? If so, should we expect nearby genes to have similar functions?What is the expected PCR amplicon size resulting from these primers?Have you found records for the human TAS2R38gene? What are the synonyms for TAS2R38that you see?Do any sequences listed have less than 100% similarity to the queried sequence? If so, what does this mean? Is there something wrong with our search parameters?What is indicated by the initial stretch of highlighted sequence? Where does the amplicon align with the sequences of the two alleles?List the nucleotide position(s) and nucleotide differences (called single nucleotide polymorphisms [SNPs]) between the two amplicon sequences.What is the ancestral (original) state of this gene at the variable nucleotide position(s) that differentiate the human alleles?Are non-human primates tasters or non-tasters, and what does this suggest about the functional evolutionary history of bitter taste receptors?Part 2: Determine Amplicon Size (1 pt)Part 3: Find PAV and AVI Alleles (4 pts)Part 4: Explore TAS2R38 Gene Sequences (10 pts)Compare the Human taster sequence with the human non-taster sequence, and thepredicted amplicons.Compare the Human PTC taster sequence with the human PTC non-taster sequence and the other primates in the database (chimpanzee, bonobo, and gorilla).****Append your text document with the sequences you collected along the way**** (5 pts)
Western Kentucky University Module 3 Bioinformatics of Genetics Paper
I’m working on a engineering exercise and need a reference to help me study.
Course Name – Week 8 AssignmentTunnel Cost ComparisonsQuestion 1: Write a 1-2 page paper. In your paper, discussion the following: Search the internet for the link to the Boston tunnel, “the Big Dig” or the “Channel Tunnel,” and London’s Millennium Dome. In spite of their poor cost performance, why do you think these projects were supported to their conclusion? What would it take to kill a high visibility project such as these? Provide a comparison of the projects, what extent were the cost overruns and how were the overruns handled by the authorities?Include a title page and adhere to the Publication Manual of the American Psychological Association (APA), (7th edition) when writing and submitting assignments and papers. Make sure to provide references. Make sure you use in-text citations in the body of the assignment.Here is a website to aid with citations:https://owl.purdue.edu/owl/research_and_citation/apa_style/apa_formatting_and_style_guide/in_text_citations_the_basics.htmlQuestion 2:Submit a document with the following documents compiled into one. Save it as “ET410 Final Report_GID.docx” and remember that you will be submitting this in ET450. Project Proposal Requirements Document and Systems Design Review Document Final Schedule Final Budget Lessons Learned Document
ET 410 Grantham University Wk 8 Online Pharmaceutical Ordering System Project
Network Security Paper
Network Security Paper.
Network Security Paper: In this paper, you will define the security strategies of Defense in Depth and Layered Security along with comparing and contrasting the strategies by explaining, at least, two advantages and disadvantages of implementing each security strategy. Support your information and make sure all information sources are appropriately cited.The paper must use APA 6th ed., 7th printing formatting and contain a title page, 3 to 5 pages of content, and a minimum of three peer-reviewed referencesIntroduction and conclusion are mandatory.
Assignment Resource(s):Layered Security: Why It Works – This article discusses why layered security works.https://youtu.be/zBFB34YGK1U Introduction to Computer Security – Information Security Lesson #1 of 12Duration: (41:47)User: n/a – Added: 9/5/13This video, the first of 12 by Dr. Soper, provides an introduction to computer security. Topics covered include dependence on technology, information assets, threats, vulnerabilities, controls, confidentiality, integrity, availability, types of attackers, methods of defense, and multi-layered security.
Network Security Paper
Alcoholism and Gabapentin Treatment
best essay writers Share this: Facebook Twitter Reddit LinkedIn WhatsApp Abstract Gabapentin was designed as a GABA analog. Currently, used for its antiepileptic and analgesic properties, most likely antagonizes high-voltage-gated calcium channels. It is also proposed that gabapentin enhances inhibitory input of GABA-mediated pathways (e.g., reducing excitatory input) and antagonizes NMDA receptors and now recently being investigated for its treatment in abstinence from alcohol dependence disorder. We report a case of an adult with alcohol use disorder (AUD) with major depressive disorder, narcissistic personality disorder, bipolar disorder, PTSD and anxiety whom has relapsed multiple times on alcohol trying to maintain abstinence. This gentleman has demonstrated sustained remission of alcoholic cravings and symptoms when exposed to gabapentin in the context of inpatient hospitalization. We review the scarce literature on the use of gabapentin for abstinence from alcohol in adults. This case demonstrates that gabapentin should be explored as a potential treatment option for adults with severe relapses of their alcohol dependence. Keywords: gabapentin, alcohol use disorder, alcoholism, anticonvulsant Introduction Alcohol use contributes to a significant problem of morbidity and mortality, not just in the United States but worldwide.1,2 It is estimated by the World Health Organization (WHO) that approximately six percent of deaths globally can be attributed to alcohol.1,2 Alcohol use is present across all medical specialties, with alcohol-related deaths, particularly associated with injury, cancer, cardiovascular disease, and liver cirrhosis; however, the implementation of medications remains limited.2 Gabapentin, a GABA-analog, with antagonistic properties at high-voltage-activated calcium channels has long been used for treatment of focal seizures and neuropathic pain; however, is now recently been investigated for its effects on alcoholic use disorder. Preclinical studies have found that gabapentin normalizes the stress-induced GABA activation in the amygdala that is associated with alcohol dependence and provides rational to investigate it as a treatment for alcohol dependence.3 Clinical studies have found that gabapentin has reduced cravings and sleep disturbance in patients with heavy alcohol use.2 Thus, gabapentin’s low abuse potential, favorable side effect profile and virtually no metabolism by the liver make its off label use an attractive option compared to benzodiazepines and other drugs. Case Report This patient is a 55-year-old-man with a psychiatric history significant for PTSD, major depressive disorder, bipolar disorder, schizophrenia spectrum disorder, substance use disorder, past suicide attempts and alcohol use disorder who has had severe episodes of emotional and behavioral outbursts involving his wife and family members. He presented to us with severe alcohol intoxication, suicidal ideation, disorganized organized and tangential thoughts, and responding to internal stimuli. He has experienced periods of sever anhedonia, often explained, as well as difficulty controlling his temper and dealing with stressful situations. Initial laboratory investigations included a CMP, a CBC, an alcohol breath test and a drug tox screen which was unremarkable except for a blood alcohol level of 0.17. Review of this patient’s medical record has revealed a longstanding history of alcohol use. He currently has been drinking a pint or two of vodka 4 – 5 days per week for an unknown amount of time; however, he has never experienced major withdrawal symptoms such as seizures or delirium tremens, but states that he has a tremor and memory concerns. When depressed, he would excessively drink and have anger surges. These severe outbursts, from alcohol, of aggression has led to a domestic assault charge, his wife asking for a divorce and a no-contact order, multiple DUI charges and his sister kicking him out of her home. Past medications and nonpharmacologic trials to address these problems included: antiepileptic drugs, antipsychotics, SNRIs, and SSRIs. None of these interventions had any substantial improvement in his recovery process. In the last one and a half years, he has required multiple chemical dependency treatments, some of which he never finished, inpatient mental health admissions due to his inability to be safe with his wife and family members at home and suicide ideation. Soon after his relapse, he became aggressive via punching holes in the walls and shooting his gun in the home. On hospital stay day 1, the patient was agreeable to starting gabapentin (100 mg t.i.d) for anxiety along with naltrexone (25 mg) and trazadone (50 mg). In the following days, the patient’s dose of gabapentin was increased to 300 mg t.i.d. It was noted by the medical team that the intensity and frequent alcohol cravings and aggressive behaviors had lessened with the ability to control these cravings. The documentation showed that he mainly had major suicidality in the absence of alcoholic cravings and his emotions and behaviors did not escalate. During his time thus far, he has been able to talk about his life providing insight and therapeutic goals while on the inpatient psychiatric services, such as attaining help with finding a permanent residence and seeking long term treatment for alcohol use. Throughout his meetings with the medical team, he was able to speak and provide insight into his past about leading to his alcohol use disorder and make gains in his therapeutic goals. Discussion This case presents the opportunity to ponder current treatment for alcohol use disorder in a patient who has developed medical and social consequences of his drinking habits (i.e., legal issues with a divorce, multiple DUIs and MDD). Currently, medications approved for AUD include the following: naltrexone, disulfiram and acamprosate.1 Also, there is off-labeled prescriptions, with less evidence but potential benefit, such as gabapentin, baclofen and topiramate.1 This case highlights the difficulties of prescribing pharmacological treatment, with the possibility of liver dysfunction and a severe mental health disorder, major depressive disorder. Given this situation, novel treatments are needed to prevent relapse of alcoholism to prevent future medical and social problems. Naltrexone is an opioid antagonist and is thought to block endogenous opioids triggered by alcohol use.1 It has been shown to decrease the total number of drinking days; however, liver failure and acute hepatitis are contraindications for its use and must be used carefully in patients with liver dysfunction.1 Acamprosate is also currently approved for alcohol use disorder, most useful for maintaining abstinence, and thought to reducing cravings and/or relapse of heavy drinking.1 Also, this drug can be used in actively drinking individuals and those with liver disease. Gabapentin, mostly used for its anticonvulsant and analgesic properties, is currently being delved into as a possible treatment for alcohol use disorder. Presently, there is not a significant amount of literature comparing it to naltrexone or acamprosate; however, in studies, it has been shown that gabapentin reduces alcoholic cravings and withdrawal symptoms, which may be beneficial to remaining abstinent.1,2,3,4,5 With its low risk of abuse and negligible side effects (favorable safety profile) gabapentin has gained support for alcohol withdrawal and dependence treatment.1,2,5,6,7 It is also not metabolized by the liver and therefore can be used in patients with liver dysfunction.1,2,6 The exact mechanism behind our patient’s sustained improvement from alcoholic cravings is unclear. It is hypothesized that the central nucleus of the amygdala (CeA) has an important role in the voluntary control of ethanol intake.3 Currently, activation of the CeA by gabapentin is thought to suppress alcohol-self administration by reducing a high-anxiety state that potentially drives excessive drinking in animal models.3 Therefore, gabapentin regulation of GABAergic neurotransmission, has potential to eradicate the high-anxiety behavior and thus normalize alcohol intake.3 Conclusion Gabapentin is an effective FDA approved drug for the management of seizures and neuropathic pain. In conclusion, studies have found that gabapentin, specifically the 1800 mg dose2,5, has been effective in the treatment of alcohol use disorder and in preventing relapse-associated symptoms such as cravings, mood and sleep disturbances. Gabapentin could be the preferred medication over benzodiazepines, a controlled and addictive substance, because of its low abuse potential, increased rates of abstinence, decreased number of heavy drinking days and relatively low side effect profile. However, at this time it is unclear how long these benefits may persist. This would provide primary care physicians an effective treatment for patients suffering from alcohol use disorder. Based on the evidence thus far, it appears that gabapentin is a novel treatment option in the management of alcohol dependence. In the future, this case proposes the need for more research using gabapentin as a first-line treatment for alcohol use disorder. References Young S, Wood E, Ahamad K. Pharmacotherapy for Alcohol Addiction in a Patient with Alcoholic Cirrhosis and Massive Upper Gastrointestinal Bleed: A Case Study. 2016;35(2):236-9. Mason B, Quello S, Goodell V, Shadan F, Kyle M, Begovic A. Gabapentin Treatment for Alcohol Dependence: A Randomized Controlled Trial. 2014;174(1):70-7. Roberto M, Glipin N, O’Dell L, Cruz M, Morse A, Siggins M, et al. Cellular and Behavioral Interactions of Gabapentin with Alcohol Dependence. [amygdala, ethanol dependence, IPSC, paired-pulse facilitation, anxiety, ethanol-self administration]. 2008;28(22):5762-71. Myrick H, Malcolm R, Randall P, Boyle E, Anton R, Becker H, et al. A Double‐Blind Trial of Gabapentin Versus Lorazepam in the Treatment of Alcohol Withdrawal. [gabapentin, alcohol dependence, alcohol withdrawal, lorazepam]. 2009;33(9):1582-8. Nichols T. Off-label use of gabapentin for management of alcohol use disorders. [gabapentin, alcohol use disorder, alcohol, detox, detoxification, dependence]. 2015;5(6):248-52. Yesil B, Elbozan B. Gabapentin withdrawal in a depressed patient: A case report. [gabapentin, withdrawal, drug abuse]. 2016;17(3):61-3. Rose MA, Kam PCA. Gabapentin: pharmacology and its use in pain management. [pharmacology, gabapentin, neuropathic]. 2002;57(5):451-62. Share this: Facebook Twitter Reddit LinkedIn WhatsApp
Rider University CNN Disaster and Recovery Discussion
Rider University CNN Disaster and Recovery Discussion.
Problem DescriptionFollowing the attacks on 9/11, many online news Web sites faced an increased number of connections from people trying to know the latest development of events. This augmented traffic quickly brought nearly every news site down, and CNN.com was not immune.On September 11, in approximately 15 minutes, CNN.com served over 132 million pages, nearly equaling the site’s all-time high. One of the biggest challenges faced by the response team was induced by cascading failures, so that increasing capacity alone was not sufficient to resurrect the site.CNN Internet Technologies’ William LeFebvre was invited to LISA 2001 to give a talk about the effects of the 9/11 attacks on CNN’s Web site and the efforts the response team did to keep the site up and running.Read a summary of LeFebvre’s talk at https://www.usenix.org/conference/lisa-2001/cnncom-facing-world-crisis (Links to an external site.) Then, using your knowledge of disaster recovery and business continuity, answer the following questions:What happened with CNN.com on September 11 2001?From a technical point of view, what were the reasons for the problem you described on the previous question?What did the CNN.com’s team do to minimize the impact of the problems?Was the disaster recovery and business continuity plan effective or were the reflexive responses from the team primarily responsible for the results?
Rider University CNN Disaster and Recovery Discussion
Hurricane Katrina Essay
Hurricane Katrina Essay. Paper Details:Assignment Instructions Assignment 3: Research Presentation Objective: Develop an audio-narrated PowerPoint presentation based on the research you have conducted about your chosen weather event. Assignment Instructions: Using the course project steps completed to date, you will develop your presentation based on the work you submitted for Assignments 1 and 2 as well as the feedback you were given. To prepare for this assignment, I recommend that you do the following: Read these directions carefully. [ [Review the grading rubric below. The grading rubric is a detailed evaluation that I will use to assess your performance. It also will help you understand what is expected of you as you prepare your assignment.] ] Message me with any questions! Presentation requirements: Your presentation will be submitted as an audio-narrated PowerPoint. For instructions on how to create audio narration in PowerPoint, see the following link: Record a Slide Show With Narration. Audio narration is a requirement! There must be a visual element (e.g., photos, videos, graphs, figures). Your presentation must contain approximately 10-15 slides (excluding references) and run approximately 5-10 minutes. Please note that less than 10% of your presentation should contain direct quotes. Proper use and pronunciation of scientific terminology are required. For help with pronunciation, see this link: Meriam-Webster Medical Dictionary Be sure to properly cite your work, both internal to the presentation as well as within the reference slide (this includes photos, graphs, figures, videos, etc.). All references listed on the reference slide should be cited internally within the presentation, and vice versa. You will submit this presentation to your classmates to review and discuss as a part of the Week Eight Forum. The required elements: Your presentation should contain the following elements in the order listed below. In addition, I expect that any feedback provided to you from Assignment 1: Annotated Bibliography and Assignment 2: The Outline be incorporated into this assignment. Please go back and review those comments. Introduction Slide(s) – this section must contain the following: Student Introduction Topic selection and reason for selecting When weather event occurred Where weather event take place Who was impacted by weather event Why is weather event relevant and important Content Slides – this section must contain the following four main subtopics (the subsections below each subtopic are recommendations to use if appropriate to your disease/condition): Weather Journal Atmospheric conditions beginning at least two days prior to event (i.e. temperature, humidity, precipitation, etc.) Atmospheric conditions on day of event (discuss the meteorology of what happened, and the conditions experienced on the ground) Atmospheric conditions extending upwards to at least two days after the event. Causation Factors instrumental in creating favorable conditions for this weather event (i.e., surface heating, upper level disturbances, frontal convergence, etc.) Societal Impacts Short-term impacts this weather event had on society (i.e. evacuations, power outages, property damage, injuries, loss of life, etc.) Long-term impacts this weather event had on society (i.e. economic losses, homelessness, mass relocations, etc.) Weather Readiness Plans to minimize, mitigate, or avoid future impacts from similar weather events (i.e. investing in weather radios or weather apps, evacuation plans, recovery centers, improving infrastructure, etc.) Conclusion Slide – this section must contain four to six points that sum up the main topics of the presentation. Reference Slide (and Internal Citations) – this section must contain the following: Internal citations – This is not just a separate section; rather, referencing should occur throughout the presentation via parenthetical citations anytime you paraphrase, make direct quotes, or use visual components from other sources. Please be sure to cite any language, images, videos, etc. in the presentation that should be cited. Reference Slide – Your paper should also have a final reference slide listing 5-10 credible sources researched for your presentation. Do not include your summary/evaluation from Assignment 1: Annotated Bibliography; simply list the references utilized in your presentation in APA format on the reference slide.MUST HAVE SPEAKERS NOTE WHICH CAN BE USED TO RECORD THE NARRATION: E-191028114104 AND 191015162453 ARE PARTS OF THIS ASSIGNMENTHurricane Katrina Essay