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The Role of GABA in Exacerbating Ulcerative Colitis

Share this: Facebook Twitter Reddit LinkedIn WhatsApp The Role of GABA in Exacerbating Ulcerative Colitis Ulcerative colitis (UC) and Crohn’s disease (CD) belong to a group of chronic and relapsing inflammatory bowel diseases (IBD) characterized by gastrointestinal (GI) symptoms (i.e. rectal bleeding, diarrhea and abdominal pain), fever and fatigue (Ma, et al., 2018). While both diseases share similar features, UC extends only from the rectum into the colon, affects only the colonic mucosa, and manifests as incessant areas of inflammation and ulceration, with no sections of normal tissue (Yadav, et al., 2016). A recent study by Benchimol, et al., (2018) showed that Canada has among the highest prevalence of IBD worldwide, with rates of Canadians with IBD expected to rise to 400,000 by 2030 (Benchimol, et al., 2018). With health care costs estimated at $2.6 billion CAD in 2018, IBD places a high burden on both the Canadian health care system and the economy (Benchimol, et al., 2018). The ongoing and debilitating GI symptoms of UC have a multifaceted impact on quality of life, and challenges related to the financial burden of medications and inequitable access to health care services remain an issue (Benchimol, et al., 2018). Treatment involves continuous pharmacotherapy, using aminosalicylates, corticosteroids and immunosuppressive drugs, with up to 80% of patients requiring surgical treatment (Yadav, et al., 2016; Rogler, Biedermann,
The sun is known to produce a lot of energy inform of heat and light. The sun produces approximately 4×1026 watts per second. It derives its energy from the fusion of the hydrogen atoms within its core. Fusion occurs when light nuclei such as hydrogen nuclei join together into heavier nuclei, like those of helium. Fusion entails the joining of nucleus in positively charged particles. This involves overcoming the force of repulsion that exists between two similar charges. Fusion occurs when positively charged nuclei come close together at a distance of approximately 10-13 centimeters apart. Subsequently, a strong nuclear force which is more powerful than the electric force takes over sticking the nuclei together. For fusion to take place, high temperatures as well as high densities are necessary to make the nuclei get close together. At high temperatures, nuclei move faster at a pace that allows the nuclei to be driven closer together and eventually merges (Culham Centre for Fusion Energy 2). High densities make sure that there are sufficient nuclei within a small volume in order for collisions to occur. The only place that one can find these conditions naturally is the sun’s core. When fusion takes place, the resulting fused massive is less than the combined masses of the particles that take part in the fusion. The lost massive nucleus is generally converted into energy, since in physic energy/matter is neither created nor destroyed, but is only transformed from one form to another ( par.4). Physicists use the equation E=MC2 to calculate the amount of energy that is generated as a result of the fusion of nucleus. In the core of the sun, four hydrogen nuclei with a mass equivalent to one proton join together to form one helium nucleus. The helium nucleus formed has a mass of 3.97 times the mass of one proton which can alternatively be expressed as 0.03x (mass of one proton) xC2. This reaction is 75% efficient. Geologists approximates that the sun can last for over 10 billion years on the fusion of hydrogen in its core (Strobel par.3). There is a lot of research that is ongoing on how to harness the energy released during fusion into a more meaningful use. Scientists believe that the energy that is given out when nucleus fuse together can be used to generate electricity. Man made nuclear energy is usually formed from machines that are referred to as nuclear reactors which are part of nuclear power plant (Dean 12). Electricity generated from nuclear fusion can greatly help to boost the high demand of energy in many industries. The hydrogen bombs which are considered as the humans’ most powerful and destructive weapons operate through the concept of fusion. Fission which refers to disintegration of the nuclei of particles is usually used to generate the intensive heat that is required to initiate the reaction of an atomic bomb. Get your 100% original paper on any topic done in as little as 3 hours Learn More Subsequently, nuclei join to form helium that gives a huge amount of energy that result to massive explosion. Increased research on the harnessing of fusion is likely to result to electricity that is more profitable than the one generated by fission in terms of supply, safety as well as cleanliness. Deuterium as well as tritium that are necessary for generation of fusion electricity can easily be obtained from seawater and tritium being made in the reactors from lithium. The amount of fuel that is required for the generation electricity through fusion is much smaller than the fuel that is needed to produce electricity through Fission. Similarly, generation of electricity from fusion will involve less pollution since the process is not accompanied by any combustion (Fraedenrich 10). The nuclear energy has been used widely in the past in the development of atomic as well as hydrogen bombs. For instance, in 1945 the United States of America bombed Hiroshima and Nagasaki towns in Japan with an atomic bomb that resulted to the death of 100,000 and 40,000 people respectively (Rosenberg 3). In 1952, the United States of America tested their first hydrogen bomb that they presumed to be a thousand times more powerful than the atomic bomb. In 1956, England opened a power plant as the first significant power plant to be established (Hersey 9). The fusion process has enabled the most powerful nations to develop nuclear bombs that pose a great danger to the safety of many people. For example, the United States of America together with Russia possesses over 50,000 nuclear bombs. This prompts a great security concern. For instance, there is a fear of what would happen in case there is an outbreak of a nuclear war. Similarly, there is a lot of fear of the repercussions that would follow if the nuclear weapons get in the hands of terrorists. In addition, if the nuclear weapons explode accidentally, they are likely to cause massive destruction. Lastly, the nuclear explosions are associated with the emission of radiation rays that are very harmful to the body cells and are known to cause deaths. Harnessing the energy emitted from the fusion process with the aim of generating electricity can help the world address its high energy demands. To achieve this, a lot of research should be conducted in the best way on how to harness fusion in the most appropriate way in order to avoid adverse effects later on (ThinkQuest.Org 12). We will write a custom Research Paper on Nuclear fusion specifically for you! Get your first paper with 15% OFF Learn More Works Cited “First Law of Thermodynamics.” 5 February, 2002. 10 Dec. 2011 Culham Centre for Fusion Energy. “Introduction to Fusion.”12 August, 2009. Web. Dean, Stephen. “Nuclear Science and Technology.” Journal of Fusion Energy. 2010,8,54, Fraedenrich, Craig. How Nuclear Fusion Reactors Work. 10 December, 2011.Web. Hersey, John. Hiroshima. New York: Alfred A. Knopf, 1985. Rosenberg, Jennifer. Hiroshima and Nagasaki. 10 December, 2011. Web. Strobel, Nick. “The Sun’s Power Source.” 24 May 2001. Web. ThinkQuest.Org. “Nuclear Energy.”10 December, 2011. 10 December, 2011.Web.. Not sure if you can write a paper on Nuclear fusion by yourself? We can help you for only $16.05 $11/page Learn More
Introduction The modern global business environment is characterized by the increasing number of international mergers and acquisitions. The reasons behind this widespread phenomenon are mostly laid on the constant rise of the economic and industrial globalization which has considerably increased the worldwide competition. Companies have various strategic options available to them in order to achieve their growth objectives and to compete effectively in the global marketplace. The first key decision they must make is whether to grow incrementally or to take a giant leap forward. Incremental growth options include introducing new products or services, enhancing existing services to grow top-line revenue, and entering into new markets. (Douglas D. Ross, 2005). If the company plan to take bigger steps in terms of growth (the ‘leap forward’ approach), perhaps the fastest way for the actual companies to expand their operations internationally in such context and to take advantage of the universal marketplace is by merging with another company or acquiring other companies. Indeed, the mergers and acquisitions represent one of the powerful factors of the further transformation of the social and economic life while the “integration of national economies into the international economy through trade, foreign direct investment, capital flows, migration, and spread of technology” are stretched all around the globe. (Wikipedia: globalization). However, mergers and acquisitions correspond to significant changes in organizational conditions that, for at least some of the new organization’s members, require from them to adjust to new cultural norms and adopt fundamentally different ways of doing things. Patrick A. Gaughan (2007) in his book writes about the mergers and acquisitions expenditures since the 20th century to nowadays by distinguishing five different waves that are illustrated by examples of mergers and acquisitions at each moment. Moreover, he presents the different types of mergers and acquisitions: horizontal and vertical transactions and also the conglomerate mergers. Plus, according to the author two major motivations dominate the activity of merger or acquisition: the growth through taking advantage of the acquired company’s resources and the synergy respecting the financial math equation that shows that “2 2 = 5”. Our chosen two organisation is NOKIA and GOOGLE Nokia’s Merger and Acquisitions and Reasons Nokia ,a name , a brand which doesn’t need any introduction .It is a world know mobile phone company which always kept itself up to date with the market needs. How much technological change they adopted could be found by comparing their previous model 3310 to the current Nokia x9 model’s. On comparing Nokia with the Ansoff’s Model(see Appendix _-_) one can realize that Nokia does occupy the majority of the market and therefore are trying to focus on Product Development and Diversification i.e. introducing new products in the current market and new market. Due to the high volume of competition it has to keep itself updated with all the features of its competitors in order to stand and compete with them side by side. Secret to Nokia’s success lies in its Merger

need completes by 2pm 11/28/17 2 part assignment

need completes by 2pm 11/28/17 2 part assignment.

Assignment Details part 1Political/Government Event Report For the Unit 6 Assignment you will compose a 500 word essay based upon your observations of a political or governmental meeting, speech, gathering, or similar activity that concerns either civil rights or civil liberties.You will need to first identify an activity that you will be able to attend. Examples of relevant activities include political speeches, town/city council meetings, school board meetings, political rallies or protests, public forums, or any similar activity that include topics pertinent to either civil liberties or civil rights. If you have any questions regarding the viability of the activity that you have in mind, contact the instructor. Though it is not preferable, you may choose to view a recorded version of the activity (speeches, Congressional proceedings, political rallies, and similar events are often available online) if your schedule precludes you from attending a “live” event.Within a 500 Word essay please include:An introduction.Describe the observed political event in detail, including the environment and people involved.Describe how the event is directly related to the study of civil liberties or civil rights and how one may better understand these topics by attending a similar event.Make note of any aspects of the event that seemed confusing to you and/or any questions that came to mind during the observation.Support your answer(s) with information obtained from the text and at least one academic source.A conclusion.Correct grammar and syntaxAPA formatThe Assignment should be at least 500 words, and must use and cite the text and primary documents as sources. Cite the work internally and in full reference at the end, following APA style guidelines. Citation is important to build the definitions, demonstrate your research, and to make it clear which ideas are yours and which are from the source. Check with the Writing Center for APA style tips and assistance. WritingCenter/WritingReferenceLibrary/ResearchCitationAndPlagiarism/Index.aspxTurnitin AnalysisA special feature is available to help you with reviewing your Unit 6 Assignment for plagiarism. When you submit your Assignment to the Unit 6 Dropbox, your Assignment will automatically be analyzed by the plagiarism detection tool, Turnitin. Soon after you submit your Assignment, you will be able to view the Turnitin Originality Report. Originality Reports provide a summary of matching or highly similar text found in a submitted paper. When an Originality Report is available for viewing, an icon will appear in the report column of the Assignment Inbox. Originality Reports are only available in the InBox. For this reason, you will need to download the report prior to the grading of the Unit 6 Assignment. To do this, click on the print icon at the bottom of the Originality Report. This will prepare a readable, PDF version of the Originality Report that you can save to your computer.Submitting Your AssignmentWhen you are ready, submit your Assignment to the Unit 6 Dropbox.To view your graded work, come back to the Dropbox or go to the Gradebook after your instructor has evaluated it.PART 2Civil RightsSince ratification of the U.S. Constitution many groups of people have struggle to achieve equality under the law. Even after the ratification of the U.S. Constitution and the Bill of Rights many people received little to no rights. In particular, women could not vote, Native Americans had limited protections, and almost all African Americans suffered the yoke of slavery.It took sixty years after the passage of the U.S. Constitution for this country to address the societal notion of equality. As per the Fourteenth Amendment, ratified in 1868, “No state shall make or enforce any law which shall abridge the privileges or immunities of citizens of the United States; nor shall any state deprive any person of life, liberty, or property, without due process of law; nor deny to any person within its jurisdiction the equal protection of the laws.” The Fourteenth, Nineteenth, and Twenty sixth Constitutional Amendments, coupled with legislation passed during the 1960s Civil Rights era greatly enhanced minority rights. In addition, Supreme Court cases such as Dred Scott, Plessy v. Ferguson, Brown v. Board of Education, Craig v. Boren, Regents of the University of California v. Bakke, and Romer v. Evans have narrowed or expanded equality.Directions: Select a group of people that you believe to have struggled or are still struggling for full legal equality under the law.Identify the historical or current circumstances of this struggle for legal equality.Identify specific actions taken by this group; and or specific actions taken by the executive, legislative, or judicial branch to address this inequality.Evaluate the effectiveness of said actions.Although slightly edited for format: these ‘responses’ were crafted by undergraduate students: Discussion Board Example
need completes by 2pm 11/28/17 2 part assignment

Co-operative Bank’s Employee Empowerment Essay

online assignment help Introduction The present banking marketplace is exceptionally competitive. Therefore, there is a need for Co-operative Bank to keep on advancing, retaining, and attracting top talent so as to possess exceptional skills that are aimed at developing people. In addition, there are wide arrays of transformations in the banking marketplace that urges banks to keep on assisting the employees to embrace the critical novel initiatives that are essential for keeping the pace (Treadway, Adams

ANTH 001 Pasadena City College Non Human Primate and Behavioral Traits Paper

ANTH 001 Pasadena City College Non Human Primate and Behavioral Traits Paper.

Essay Section – Be able to write an essay on any two of the following five topics: (no citation needed) Don’t struggle with the length, focus on the content of the topic.1.Discuss one pro and one con of medical testing on non-human primates, using information about the biological or behavioral similarities and differences between humans and other primates to support your answer. 2.Identify two biological and two behavioral traits that distinguish members of the Homo genus from earlier Australopithecines. Which hominin species do you consider the first to be truly “human”, and why?3.Discuss one hypothesis proposed to explain Neanderthal extinction and the evidence used to support it. Then, identify and explain one strength and one weakness of the hypothesis. 4.Define the Biological Race concept and explain three (3) problems with applying this concept to humans. 5.Define epigenetics, identify one epigenetic factor, and explain how it can influence human biology.
ANTH 001 Pasadena City College Non Human Primate and Behavioral Traits Paper

Nursing nmc code of conduct.

LEARNING OUTCOME 5 NURSING NMC CODE OF CONDUCT. (A.)A code of conduct is a set of customary principles and expectancy that are considered binding on anybody who is member of a certain group. Nursing and midwifery practice in the United Kingdom are bound by a set of precepts and standard that set the least requirements for anyone wishing to practice nursing or midwifery within England, Scotland, Wales, Northern Ireland and Island. There is a more advance set of ethical and behavioural pattern that all nurse and midwife working in the United Kingdom must follow (NMC 2008).This is maybe the most important of the pattern set by the regulatory body for nurses and midwives as it comprises the ethical and moral codes that they are expected to obey. The code applies to anyone in the register; nevertheless the importance and need for codes of practice and conduct goes beyond nurses and midwives and their everyday contact with patients. Even when not on duty, they must still stick to the principles and values comprising the code, especially as they directly connected to the women and people that they have been in their care. An example of this is respecting your client confidentiality. There are no much difference in the NMC code of conduct United Kingdom and that of Nigeria. In the aspect of treating people equally without prejudice and discrimination, all humans are equal and must be treated kindly and with respect. Confidentiality is another important part of the code of conduct which states that sharing of information is not right except in the case where the person is at risk of harm or in compliance with a court case. In writing of inform consent one must ensure that the client is of legal age which is 18years in Nigeria. In a situation where the client is under aged, the parent or next of kin signs the informed consent on his or her behalf. A nurse should maintain boundaries in a professional by not accepting gift, favours because it might be interpreted as an attempt to gain special preference. A nurse should avoid careless, malpractice and abuse while providing care to client. Clients do have a right to know about their conditions. A nurse should be accountable to the public at all time by helping to protect the public against harmful dangers and agents. As a nurse one must be ready to implement global health initiatives and participate in national and international conferences. (B.)Be aware that the rules of obtaining consent apply equally to those who have mental illness. Under mental health act it is very important that clients are checked under statutory powers, knowing the conditions and safeguards needed for giving care and treatment without consent. (C.)An area of the code that I am interested in is the area of informed consent. In Nigeria a clients legal age that allows him or her to sign informed consent is 18 years and above but in a situation where the client is under aged, the guardian or next of kin can sign the informed consent on his or her behalf. While in the United Kingdom, if the client is (a minor) under the age of 16,it becomes a complex case because it is believed that they are not matured enough to have a superior power of discernment and reasoning to make decision. This is a more similar case with that of Nigeria. Buts the difference is that, in Nigeria even if the client is 16 or 17 years and with parental responsibility the client will still not be given the opportunity to sign an inform consent. However the explicit wish of a minor should be thought about by an investigator, there are gillick competent minors that are able of consenting in their own right to treatment procedures, given that, in the view of the professional concerned, they had gotten the nature of the treatment she is going to have and its potential advantage and disadvantage and were adequately mature intellectually and emotionally to make a judgement. In high schools in the United Kingdom, consent is important to the appropriateness of treatment and school nurses must have a sound consent before he or she can lawfully go on with treatment for a child. For children who are very young who do not have the power to make consent for treatment, the school nurse will depend confidently on the consent of someone acting on the power of a person with parental responsibility. As a child rows with age the law permits them to make consent to treatment decisions where they have the power to do so. School nurses can go on with treatment plan and advice if the child is seen or considered to be gillick competent. Right to consent is not subject to individual will or judgement without restriction set at puberty: it is a must by the school nurse who must be comfortable that the child is old enough to fully understand the consequences of the particular decision they are making. The more complicated the decision, the greater the maturity and intelligence needed to reach ability, as there will be a lot for the child to understand. School nurses will need to be comfortable with the child to fully estimate the difficult issues that needs to be considered before they can safely go on that the child has power to consent to treatment. In a case were the child is asking for treatment and counselling in relation to sexual activity such as contraceptive, then the nurse must also be sure that they are acting to protect the child and they meet the need of the sexual offences Act 2003.This is best achieved by recording the treatment and counselling given in line with Lord Fraser’s guidance in Gillick V West Norfolk and Wisbech AHA (1986) School nurses must keep their patients medical needs confidentially. This duty is draw from their legal, pertaining to and professional sense of duty and requires that as a rule they will not open patient information.However, the need to share information with others is vital to help deliver necessary care and protection of patients. While not proper disclosure is never welcomed, always using the duty of confidence as an excuse never to share information can lead in poor care and even bad report. School nurses must look at each case on its merits. Whenever needed the consent of the patient should be gotten before disclosure. Disclosure of patient information without consent is allowed in the public interest or where regarded by law and it is important that school nurses carefully balance the overall need for confidentiality against the needs and welfare of the patient that might need the information to be shared with necessary source. (D.)The sufficiency of informed consent is a vital part to consider when caring for patients.Weisz

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