Here’s the topic of the writing,Use the assigned reading “The Power of Context” (which I will give you before you start working) and 2 another legitimate sources related to “Broken Window Theory” to discuss which aspects of Broken Window Theory seem effective and which aspects seem to e problematic. As evidenced from your reading and research, what would be the ideal version of Broken Windows?Here’s is the requirements: 1. The paper has to be at least 1,500 words long2. The paper should contain 5 and only 5 paragraphs, one introduction which end with the thesis of the whole paper, 3 body paragraphs supporting the thesis with the topic sentence at the begining, and a conclusion restating the thesis.
The Power of Context, writing homework help
Ancient Greece and Athletics” Please respond to the following, using sources under the Explore heading as the basis of your response: Describe
the ancient Greek competitive character, and compare the ancient
Olympics (as a festival featuring athletics) to the Olympics today,
identifying any major differences. Explain what the Olympic rules
regarding females and evidence, such as the “running girl” artifact,
reveal about female status and Greek athletics in particular Greek
city-states. ExploreAncient Greek Athletics and Female Status Chapter 4 (p. 118), Olympics. Chapters 4 (pp. 113-114), women in Sparta; For Athens later, see pp. 137-8. British Museum’s Running Girl artifact at http://www.britishmuseum.org/explore/highlights/highlight_objects/gr/b/bronze_figure_of_a_girl.aspx Philadelphia’s Penn Museum on Women and Greek athletics at http://www.penn.museum/sites/olympics/olympicsexism.shtml
discussion week 2 Ancient Greece and Athletics
I’m working on a computer science case study and need a sample draft to help me understand better.
MANAGEMENT INTEGRATION AND IMPLEMENTATIONIn Module 4 SLP, we return our focus from the specifics of information technologies and the formulation of ideal strategies to the wider world of real corporate behavior. Our emphasis now shifts to the actual implementation of information technologies and the sociotechnical dynamics that implementation not infrequently founders upon. No technical solution—however brilliantly designed or competently backstopped or elegantly integrated with other corporate plans—is any better than its implementation at the lowest levels of the system to which it is addressed. All too frequently, plans and solutions are developed in a vacuum apart from the context within which they are to be deployed and used. It is hard to overestimate the quantity of corporate resources that have been squandered on poor IT implementations over the years—to say that it would exceed the GNP of many third world countries would probably not be an exaggeration. Implementation is by no means an all-or-nothing proposition; even though the full measure of system changes may not be as successful as desired, there can often be positive local results, particularly if the implementation process is oriented toward learning as well as doing, or even more so, doing unto others. The one sure way to implementation failure is to assume that all knowledge resides in IT management—or even in management generally. Success is inevitably based on user involvement in varying degrees, generally more rather than less.All modules in the course draw on everything that you have learned in the program; however, this module most specifically draws on your courses in computer-human interaction, systems development, and project management as well as on your general introductory courses. Implementation is a drawn-out process requiring effective collaboration among many different kinds of specialists and generalists, extended over time and across space, and requiring explicit attention to both the social and technical systems of the organizational units affected. Above all, implementation must be sensitive to feedback, resilient enough to deal with changing circumstances, personnel, and goals, and focused much more on the users than on the technologists. Effective implementation always embraces the fundamental sociotechnical criterion of “incompletion”—that is, the idea that no change process is ever “finished” as such, but that change is an ever-flowing river in which one set of adjustments is merely the prelude to another set. Sociotechnical life in organizations is a soap opera, not a novel. There is never a “happily ever after,” just an ever-evolving and constantly reconfiguring cast of players and problems. Sometimes things get better; sometimes they get worse—but they will always be different.Videos of Interest… Something to Think About…Andrew McAfee discusses an array of revolutionary technologies that are replacing routine jobs with machines that can speak, understand, translate, and hear. McAfee believes that this kind of innovation will lead to creating new jobs that involve more than enhancing creativity. He refers to this cycle of innovation as “The New Machine Age.” Think in terms how technology-driven changes could impact the ERP implementation for Aux Bons Soins’ case study below.TED Ideas Worth Spreading. (2012, September). Andrew McAfee: Are droids taking our jobs? Retrieved from http://www.ted.com/talks/andrew_mcafee_are_droids_…For the last assignment, we will be introducing a new case, the real-world story of an ERP implementation for Aux Bons Soins. This case details the rather frustrating experiences that the company encountered in trying to implement an integrated management system after an acquisition and merger, and the range of circumstances that affected the process. Not every implementation is this sticky, but in varying ways most partake of greater or lesser parts of this experience. Please note that there is nothing particularly pathological about the experience described here, despite the frustrations experienced. There are no great villains, but neither are there any great heroes; implementation seldom turns up either. This may seem a rather inconclusive note on which to conclude both this course and your IT management program, but it is how things are. For better or worse, this is what real IT management is all about—the good, the bad, the ugly, and above all the reasonably acceptable. Over the next decades, the profession is likely to evolve far beyond any ways that can be reasonably forecast today; after all, 20 years ago there was not any such thing as the Internet, and today’s information environment was ranked science fiction. You are entering the profession at a most exciting and dynamic time; always remember how much you do not know, but also remember that you do know how to learn.Please read the following parts of the case:Bernier, C., Roy, V., & Brunelle, E. (2006) An ERP Story: Background (A). International Journal of Case Studies in Management. 4(1):March.Bernier, C., Roy, V., & Brunelle, E. (2006) An ERP Story: Troubles Ahead (C). International Journal of Case Studies in Management. 4(1):March.Bernier, C., Roy, V., & Brunelle, E. (2006) An ERP Story: Epilogue (D). International Journal of Case Studies in Management. 4(1):March.Use information from the course background readings as well as any good quality resource you can find. Please cite all sources and provide a reference list (use APA format) at the end of your paper.Your answer to the following will be assessed:What were the main causes of the difficulties with the project at Aux Bons Soins?What were the key elements that led to the success of the project at Aux Bons Soins?Minimum 3–5 pages excluding cover page and references (since a page is about 300 words, this is approximately 900–1,500 words).Demonstrates clear understanding of the subject and addresses all key elements of the assignment.Demonstrates mastery conceptualizing the problem. Shows analysis, synthesis, and evaluation of required material.Demonstrates writing proficiency at the academic level of the course; addresses the Learning Outcomes of the assignment.Uses relevant and credible sources to support assertions. Assignment is well organized and follows the structure of a well-written paper.Uses in-text citations and properly formats references in APA style
ITM 490 TUI Management Integration and Implementation Essay
Food And Wine Menu
Food And Wine Menu.
Create a fictitious tasting menu consisting of 5 courses of food, and 5 appropriately paired wines. The menu should be printed and presented as if it were given to guests at a wine-dinner event of a fine dining restaurant. Attached to the menu should be a separate piece of paper describing the inspiration for the menu and its items, as well as a description of each wine and why it pairs with the chosen dish. Document below is an example of what is expected for the final draft. Do not copy the example.The link is information about different types of wine lectures in class. https://drive.google.com/file/d/1FFEO3cCTOMscOrTsI…
Food And Wine Menu
Drug Mechanisms and Reactions
online dissertation writing Drug Mechanisms and Reactions. Phase 1: Drug Metabolism The whole range of biochemical processes that occur within an organism, Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The biochemical reactions are known as metabolic pathways and involve enzymes that transform one substance into another substance, either breaking down a substance or building a new chemical substance. The term is commonly used to refer specifically to the breakdown of food and its transformation into energy. The liver is the principal site of drug metabolism. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active sometimes even more than the parent compound. An inactive or weakly active substance that has an active metabolite is called a pro-drug, especially if designed to deliver the active moiety more effectively. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization, whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver. Drug metabolism rates vary among patients. Some patients metabolize a drug so rapidly that therapeutically effective blood and tissue concentrations are not reached, in others, metabolism may be so slow that usual doses have toxic effects. Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). For many drugs, metabolism occurs in two phases: Phase I reactions: Which involve formation of a new or modified functional group or cleavage, these reactions are nonsynthetic. Phase II reactions Which involve conjugation with an endogenous substance, these reactions are synthetic. Metabolites formed in synthetic reactions are more polar and more readily excreted by the kidneys (in urine) and the liver (in bile) than those formed in nonsynthetic reactions. Some drugs undergo only phase I or phase II reactions, thus, phase numbers reflect functional rather than sequential classification. Phase I Drug Metabolism Phase I metabolism includes oxidation, reduction, hydrolysis and hydration reactions, as well as other rarer miscellaneous reactions. Oxidations performed by the microsomal, mixed-function oxidase system (cytochrome P450-dependent) is considered separately because of its importance and the diversity of reactions performed by this enzyme system. Classification of Phase I Reactions: Oxidation Reduction Hydrolysis Hydration Dethioacetylation Isomerization Oxidations involving cytochrome P450 (the microsomal mixed-function oxidase) The mixed-function oxidase system found in microsomes (endoplasmic reticulum) of many cells (notably those of liver, kidney, lung and intestine) performs many different functionalisation reactions. CYP 450: The cytochrome P450(CYP) enzyme system consists of a superfamily of hemoproteins that catalyse the oxidative metabolism of a wide variety of exogenous chemicals including drugs, carcinogens, toxins and endogenous compounds such as steroids, fatty acids and prostaglandins. The CYP enzyme family plays an important role in phase-I metabolism of many drugs. The broad range of drugs that undergo CYP mediated oxidative biotransformation is responsible for the large number of clinically significant drug interactions during multiple drug therapy. All of these reactions require the presence of molecular oxygen and NADPH as well as the complete mixed-function oxidase system (cytochrome P450, NADPH-cytochrome P450 reductase and lipid). All reactions involve the initial insertion of a single oxygen atom into the drug molecule. A subsequent rearrangement and/or decomposition of this product may occur, leading to the final products formation. (i) Aromatic hydroxylation: This is a very common reaction for drugs and xenobiotics containing an aromatic ring. In this example the local anaesthetic and antidysrhythmic drug, lignocaine, is converted to its 3-hydroxy derivative. (ii) Aliphatic hydroxylation: Another very common reaction, e.g. pentobarbitone hydroxylated in the pentyl side chain. (iii) Epoxidation: Epoxides are normally unstable intermediates but may be stable enough to be isolated from polycyclic compounds (e.g. the precarcinogenic polycyclic hydrocarbons). Epoxides are substrates of epoxide hydrolase (discussed later), forming dihydrodiols, but they may also spontaneously decompose to form hydroxylated products or quinones. It has been suggested that epoxide formation is the first step in aromatic hydroxylation. (iv) Dealkylation: This reaction occurs very readily with drugs containing a secondary or tertiary amine, an alkoxy group or an alkyl substituted thiol. The alkyl group is lost as the corresponding aldehyde. The reactions are often referred to as N-, O- or S-dealkylations, depending on the type of atom the alkyl group is attached to. (v) Oxidative deamination: Amines containing the structure -CH(CH3)-NH2 are metabolised by the microsomal mixed-function oxidase system to release ammonium ions and leave the corresponding ketone. As with dealkylation, oxidative deamination involves an intermediate hydroxylation step with subsequent decomposition to yield the final products. The product of the oxidative deamination of EPI or NE is 3,4-didydroxyphenylclycoaldehyde (DOPGAL). DOPGAL is subject to reduction to the corresponding alcohol (3,4-dihydroxyphenylethylene glycol, DOPEG) or oxidation to the corresponding carboxylic acid (3,4-dihydroxymandelic acid, DOMA), the latter being the major pathway. (vi) N-oxidation: Hepatic microsomes in the presence of oxygen and NADPH can form N-oxides. These oxidation products may be formed by the mixedfunction oxidase system or by separate flavoprotein N-oxidases. The enzyme involved in N-oxidation depends on the substrate under study. Many different chemical groups can be N-oxidised including amines, amides, imines, hydrazines and heterocyclic compounds. (vii) S-oxidation: Phenothiazines can be converted to their S-oxides (sulfoxides (S¼O) and sulfones (¼S¼O)) by the microsomal mixed-function oxidase system. (viii) Phosphothionate oxidation: The replacement of a phosphothionate sulfur atom with oxygen is a reaction common to the phosphothionate insecticides, e.g. parathion. The product paraoxon is a potent anticholinesterase and gives the potent insecticide action as well as the toxicity in humans. Oxidations not catalysed by cytochrome P450 (Non-Microsomal) A number of enzymes in the body not related to cytochrome P450 can oxidize drugs. (i) Alcohol Oxidation by Alcohol dehydrogenase: This enzyme catalyses the oxidation of many alcohols to the corresponding aldehyde and is localised in the soluble fraction of liver, kidney and lung cells. This enzyme uses NAD as co-factor and is a true dehydrogenase. (ii) Aldehyde oxidation: Aldehydes can be oxidised by a variety of enzymes involved in intermediary metabolism, e.g. aldehyde dehydrogenase, aldehyde oxidase and xanthine oxidase (the latter two being soluble metalloflavoproteins). (iii) Oxidation by Xanthine oxidase: This enzyme will metabolise xanthine-containing drugs, e.g. caffeine, theophylline and theobromine, and the purine analogues to the corresponding uric acid derivative. Metabolic Reduction (i) Azo- and nitro-reduction can be catalysed by cytochrome P450 (but can also be catalysed by NADPH-cytochrome P450 reductase). (ii) Ring cleavage: Epoxides can be converted back to the parent hydrocarbon, e.g. benzo(a)anthracene- 8,9-epoxide whereas some heterocyclic compounds can be ring cleaved by reduction. (iii) Reductive defluorination: Fluorocarbons of the halothane type can be defluorinated by liver microsomes in anaerobic conditions. Metabolic Hydrolysis Esters, amides, hydrazides and carbamates can readily be hydrolysed by various enzymes. (i) Ester hydrolysis: The hydrolysis of esters can take place in the plasma (nonspecific acetylcholinesterases, pseudocholinesterases and other esterases) or in the liver (specific esterases for particular groups of compounds). Procaine is metabolised by the plasma esterase, whereas pethidine (meperidine) is only metabolised by the liver esterase. (ii) Amide hydrolysis: Amides may be hydrolysed by the plasma esterases (which are so non-specific that they will also hydrolyse amides, although more slowly than the corresponding esters) but are more likely to be hydrolysed by the liver amidases. Ethylglycylxylidide, the N-deethylated phase 1 product of lignocaine, is hydrolysed by the liver microsomal fraction to yield xylidine and ethylglycine. (iii) Hydrazide and carbamate hydrolysis: Less common functional groups in drugs can also be hydrolysed, such as the hydrazide group in isoniazid or the carbamate group in the previously used hypnotic, hedonal. Factors Affecting Metabolism Many factors can affect liver metabolism, such as: In aging, the numbers of hepatocytes and enzyme activity declines. Diseases that reduce hepatic blood flow like heart failure or shock can also reduce the metabolic potential of the liver. Also the use of other drugs as well as dietary and environmental factors can influence liver metabolic function. Metabolism can also be altered due to a genetic deficiency of a particular enzyme. Differences in metabolism that result from functional genetic polymorphisms can be accommodated by knowing the frequency of different genotypes, and by modifying either the enzyme abundance (null alleles, for example, in the case of CYP2D6 ‘poor metabolizers’) or the intrinsic enzyme activity (for example, CYP2C9 variants). Data on developmental changes in the abundance and activity of different CYPs can also be incorporated into the models to predict hepatic clearance in neonates, infants and children. Conclusion Metabolism is the breakdown of Drugs inside the body, to disable their activity, forming inactive metabolites, however some drugs are either not affected by metabolism or activated by it, some even form toxic metabolites Examples: Imipiramine not affected by metabolism: Paracetamol produce Toxic Metabolite Metabolism occurs in two phases, Phase I Metabolism, and Phase II Metabolism. Phase I Metabolism converts the drug into metabolite by formation of a new functional group or modifying it, while phase II Metabolism or reactions involve conjugation with indigenous substance. Phase I Reactions Include: Oxidation, reduction, hydrolysis and hydration reactions, and other rare miscellaneous reactions. Oxidation can be divided into Microsomal or non Microsomal according to whether it involves mitochondrial CYP 450 enzymes. Oxidation involves: Microsomal Aromatic Hydroxylation, Aliphatic Hydroxylation, Epoxidation, Dealkylation, oxidative deamination, N- oxidation, S-oxidation and Phosphothionate oxidation. Non-Microsomal Alcohol Oxidation by Alcohol dehydrogenase, Aldehyde Oxidation and Oxidation by Xanthine oxidase. Reduction involves: Azo- and nitro-reduction, Ring cleavage, Reductive defluorination Hydrolysis involves: Ester hydrolysis, Amide hydrolysis, Hydrazide and carbamate hydrolysis Drug Mechanisms and Reactions
Technical writing research proposal for purchasing request
Technical writing research proposal for purchasing request.
The company you work for has decided to make a major purchase. This purchase can be software, technology, equipment, training, or anything else needed for the company’s day-to-day operations. Your supervisor has assigned you the task of creating a research proposal for the company to help guide them in this purchase. Create the introduction, body, and closing for your research proposal that you began in Unit VI. Include research from the sources you located in the last unit to help you build an effective proposal. Organize the body of your proposal clearly so that readers can locate the essential information easily, including at least one visual. Use the sample proposal that begins on page 309 in your textbook as a guide for this assignment. EH 3341, Technical Writing 5 Research proposal should be a minimum of eight pages, including the work that you submitted in the previous unit. 1 Visual4 Sources8 Pages
Technical writing research proposal for purchasing request
College of Wilmington Information Systems Management Questions
College of Wilmington Information Systems Management Questions.
Read Chapters 8-9 – from Information Systems for Business and Beyond (found under Course Resources)Read Chapter 10 from Information Systems: A Manager’s Guide to Harnessing Technology (from under Course Resources)What did you learn this week?Connect this week’s topics to your professional career.What examples of this week’s topics do you see in your everyday life?What topic from this week was most interesting to you?Is there a current event that ties to the reading assignments from this week?Is there a topic you’d like to learn more about? Why?Is there a topic you did not enjoy? Why?
College of Wilmington Information Systems Management Questions