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Peptidylarginine Deiminase and Neurodegenerative Diseases

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Peptidylarginine Deiminase and Neurodegenerative Diseases. Abbreviations AD: Alzheimer’s disease CNS: Central nervous system GFAP: Glial fibrillary acidic protein NFT: Neurofibrillary tangles MAP2: Microtubule-associated protein 2 MBP: Myelin basic protein Nef3: Neurofilament 3 PAD: Peptidylarginine deiminase RT-PCR: Reverse transcriptase-polymerase chain reaction SP: Senile plaque Introduction Neurodegenerative diseases, such as Alzheimer’s disease and Multiple Sclerosis, are a group of progressive conditions, which affect a person’s learning abilities and the day-to-day routine management. Citrullination/deiminasion is a process describing the enzymatic involvement in conversion of arginine residues into citrulline in target proteins. Here, is a review, entailing the main features of the peptidylarginine deiminase (PAD) enzyme family, with a view on its history, presence and future in neurodegenerative disorders. Background The amino acid Citrulline was firstly mentioned in 1955 (Smith and Young), and the citrullination process of L-arginine conversion to L-citrulline was firstly described in 1958 (Rogers and Simmonds).Citrullination is a posttranslational process, and also results in a 1Da decrease in size, due to an hydrolytic reaction (Vossenaar et al., 2003; Gyorgy et al., 2006; van Venrooji and Pruijn, 2003). However, it was only in 1977 when peptidylarginine deiminases, the enzymes that are responsible to the citrulline modification, were firstly described (Rogers et al.). Alzheimer’s disease: GFAP, an astrocyte-specific marker protein, is involved in the progression of Alzheimer’s disease via PAD2 citrullination. The increase of PAD2 can be seen in the hippocampi of AD patients. GFAP and vimentin citrullination was also identified by using a 2D gel electrophoresis and MALDI-TOF mass spectrometry. Activation of PAD occurs upon a mass influx of Ca2 , and therefore an increase in citrullinated proteins (Keller et al., 2000; Maccioni et al., 2001). The PAD family consists of five known members (1-4Peptidylarginine Deiminase and Neurodegenerative Diseases
Eth501 case2. I’m studying and need help with a Business question to help me learn.

Group Dynamics and Teams
We will continue our experiential approach to the study of Organizational Behavior by engaging in a personal applied case on the topic of group dynamics and teams. As in Module 1, use the following outline to structure your 4- to 6-page paper. You may use the subtitles as headings for your paper.
Introduction: Discuss the topic of the paper and how you will approach it. It is best to write this section after you have written the rest of the paper.

Concrete Experience: Begin with a specific situation/event. Describe an experience with a group or team that was meaningful to you. It may have been an extraordinarily good experience – or it may have been an experience that did not work out very well at all! The important point is that it should be an experience which you would like to understand better. Be objective and focus on just the facts: who, what, where, when, and how – as if you were composing a newspaper article.
Reflective Observation: Reflect upon that experience from multiple perspectives of persons involved or affected in the experience. Step back from the situation, look at the experience from your own viewpoint, and from the perspective of all other parties involved or affected. You want to look at the circumstances surrounding the experience from every relevant point of view. Why did you behave the way that you did? Why did others behave the way that they did? Did others have the same positive (or negative) experience? Explain. (Note: your discussion of theories and models from your module materials belongs in the following section.)
Abstract Conceptualization: (This Abstract Conceptualization section is the “heart” of your paper.) Use critical thinking skills to understand and interpret the experience at a deeper, more generalizable level. Interpret and understand the events you have described by drawing on the concepts, theories, and models in the background material from this module. Explain how they apply to your experience. For example, what behavior patterns can you identify in yourself and others that are similar to the ones described in the material on communication, teams, and conflict management? Does the model of Force Field Analysis (home page) help you better understand why people behaved the way they did? Be sure to apply at least three concepts, theories, and/or models and cite all references to concepts, ideas, and/or quotes that you use from any outside source.
Active Experimentation: Identify ways to respond to the next occurrence of a similar experience. What have you learned about the way groups work from this analysis? What have you learned from your mistakes? How are you going to put what you have learned to use? What actions will you take to build more effective work teams in your job?
Conclusion: Sum up the main points of your analysis and the key learning you are taking from it.
Reference List: List all references that you have cited in the paper using APA formatting. References include materials from the required background readings as well as any outside internet or library sources you used in researching and writing your paper. If you have APA questions, refer to the optional listings on the background page.
Eth501 case2

The Decline of the West is a two-volume work written in the first half of the 20th century by a German historian, Oswald Spengler. The work is truly unique as the author used it as a tool for declining the view of the history of Western civilizations. He makes essential points highlighting the idea that history should be considered from the prospects of various cultures rather than epochs. In this report, the summary of the book, as well as the main ideas made by Spengler, will be presented. The conclusion will summarize the primary points of the essay. The Decline of the West represents a philosophical discussion of Western understanding of history and introduces new ideas that contradict some Eurocentric views of history. As it was mentioned above, the primary idea of the author is that history should be reviewed not in terms of time but in terms of cultures. Spengler reveals eight primary civilizations, such as Babylonian, Egyptian, Chinese, Indian, Greek and Roman, Arabian, Western, and Mexican. The author calls his work a “morphology of history,” demonstrating that each culture should be considered separately due to the numerous differences between them (Spengler 49). Therefore, all of these cultures are described independently in the frames of the work. Also, Spengler conducts a comparative analysis of the civilizations and their primary elements, revealing their similarities and differences. Thus, the historian identifies common features of humans and asserts that men of Babylonian, the Egyptian, the Indian, the Chinese, and Roman civilizations tend to be strong-minded and non-metaphysical (Spengler 50). It is fair to note that even though all the cultures are discussed, the author focuses mostly on Greek and Roman, Arabian, and Western civilizations. However, according to Spengler, there is no culture that can be called dominant. The purpose of the work is to understand the civilizations rather than find a superior one. Each culture is examined in terms of its stages of development, such as birth, time of prosperity, degradation, and death. Although the terms “culture” and “civilization” are often used interchangeably, Spengler utilizes the word “culture’ describing the time of prosperity of objects and the word “civilization,” discussing its collapse. The main difference between Spengler’s and Western history is that Eurocentric works revolve around facts rather than abstract propositions, as in The Decline of the West. Another difference is that Spengler expresses his pessimism talking about the history and future of human beings, while Western historians are famous for their enthusiasm and optimistic attitude. It can be concluded that the purpose of Spengler’s work is to examine history in a way that is different from the traditional Eurocentric approach. The author focuses on cultures and civilizations, revealing their primary peculiarities and features. Spengler rejects the ideas of Western history, concentrating on abstract concepts rather than facts. Moreover, Spengler’s tone of the narrative is quite pessimistic, unlike the optimistic style of writing of Western scholars. In general, The Decline of the West is unique writing that helps readers to look at world history from another, unfamiliar and unusual angle. It explains the interest of the world community in the book, which is still popular almost a century after its first publication. Therefore, the work can be recommended for reading not only to historians or philosophers but also to those who want to understand global cultures and key historical events. Get your 100% original paper on any topic done in as little as 3 hours Learn More Work Cited Spengler, Oswald. The Decline of the West: Volumes 1

Will Joe Bidens Proposed Taxes on Capital Corporate Finance Article Paper

Will Joe Bidens Proposed Taxes on Capital Corporate Finance Article Paper.

I’m working on a english discussion question and need support to help me study.

Post the link to an article related to an area of corporate finance and provide a review of the article. The article should come from the Wall Street Journal, The Economist, Fortune, or another well-respected financial news source and have a publication date after April 1, 2021.Provide a two paragraph review of the article using correct grammar. In the first paragraph, provide a summary of the article in your own words. In the second paragraph, provide your own thoughts on the article.Each paragraph should be 250 words each.
Will Joe Bidens Proposed Taxes on Capital Corporate Finance Article Paper

I need someone to write my a script for my literature project

online homework help I need someone to write my a script for my literature project. I need support with this Literature question so I can learn better.

it is about book called When My Brother Was an Aztec. Also, I am assigned to do New Historicism analysis and to talk in Group. Also, you have to support your idea with words sentences from different poems.
here is the assignment file and how to do it. First page of uploaded assignment file is an example of the assignment.
my part is New Historicism.
here is the link of the book: https://books.google.com/books?id=QsDbAgAAQBAJ&pri…

I need someone to write my a script for my literature project

Anthropology homework help

Anthropology homework help. Did the defendant Williams waive his right to counsel by letting the police officer know where the body was? Whether the officer’s “Christian burial speech” an interrogation that violated defendant’s Sixth Amendment right to counsel.,Did the defendant Williams waive his right to counsel by letting the police officer know where the body was?,BREWER, WARDEN v. WILLIAMS., ,430 U.S. 387 (1977), ,Facts:, ,Procedural, The state court denied the defendant William’s motion to suppress the incriminating statement that he made to the police officer while the drive to Des Moines. He was convict ed murder after the trail. The Supreme Court (Iowa) held that the defendant Williams had waived his right to the presence of his counsel during the drive with the police officer. Williams petitioned for a writ of habeas corpus in the Federal district court, the federal district court concluded that William’s right of counsel has been violated, The Court of Appeals for the Eighth Circuit affirmed this judgment and the U.S. Supreme Court granted certiorari.,Substantive, On the afternoon of December 24, 1968, the defendant Williams abducted and murder 10-year-old girl. Williams conferred with his lawyer and turned himself to the police department after 2 days (On the morning of December 26).  The police officer was told by his lawyer that Williams was not to be questions during transportation. During the drive, an officer appealed to Williams’ religious beliefs. After that, Williams told the police officer to where he buried the body.,Issues:,1.Whether the officer’s “Christian burial speech” an interrogation that violated defendant’s Sixth Amendment right to counsel,2. Did the defendant Williams waive his right to counsel by letting the police officer know where the body was?, ,Rule,Firstly, under the Sixth Amendment dictates that the defendant has right to the assistant of counsel.,Secondly, the court has the burden to show that the distinction between a voluntary act and the waiver of a right to counsel.,Analysis:, 1. There were no questions that judicial proceeding against defendant Williams when he was arraigned in the Davenport. It meant that the ,Sixth Amendment, right to counsel was applied before the defendant Williams transferred to Des Moines. The police officer who was called Leaming improperly interrogated Williams without an attorney through by his “Christian burial Speech” which meant that the police officer violated the Sixth Amendment.,1. The court had to show that Williams intentionally waived his right to counsel, but the Court did not have evidence to show it. The police officer was to not ask question by defendant’s lawyer, and the defendant did not have to make any statements as well. Further, it happened after the police officer used Williams’s religion to make the defendant confessed. Therefore, The State court could not affirm that Williams intentionally waived his right to Counsel.,Conclusion, Further, the defendant Williams was denied his constitutional right of counsel,Lastly, he was denied the constitutional protections defined by court,Attachments,Click Here To Download,Anthropology homework help

Is the Television Series, Friday Night Lights Literary? Explicatory Essay

The high school football drama, Friday Night Lights, is a great piece of literary work. This is a great television drama, which reflects different literary characteristics, just like other literary works, such as poems, novels, short stories, paintings, plays, and others (Heffernan 1). While there are non-literary works, they tend to be formal with clear structures and form, precise function, and style. This essay focuses on the use of characters, plot or episodes, and storyline to show that Friday Night Lights is literary. Friday Night Lights has characters that meet qualities of other characters in works of literature. Characters are people in the narrative or the television series. The television series has round characters, who appear to be complex and experience several development and surprise audience. Characters vary from one episode to the next one. However, the focus remains on the main character, the Panthers’ football coach Eric Taylor (Berg 1). The director creates a coach who must struggle to balance his roles as a father, his status as a coach for a demand fans, and his own ambitions. Another character is Tami Taylor, the coach’s wife. She becomes a principal at Dillon High School from a counselor. In addition, Julie Taylor, the teenage daughter of the coach is also a central character in the series. However, it is only Tami and the coach who appear in all episodes of show. Tension sets in the family as Tami gets pregnant and gives birth to another baby. Julie rebels against her parents. Players are also important characters in the television drama. Football players also change as the plot develops. For instance, Jason Street is the star quarterback who sustains a serious injury that would eventually get him out of the game and make him handicapped. Jason must struggle in order to adjust to his new life. Lyla Garrity also changes from a cheerleader to a youth leader at the church. The television series depicts characters who struggle and develop to pick up new roles or responsibilities in their lives. Generally, the show depicts various characters of a small town, Dillon who must deal with several challenges in the contemporary American society associated with football. These characters must develop to handle family issues, life lessons, child issues, abortion, alcoholism, football and school funding, and poor economic progress and opportunities. Get your 100% original paper on any topic done in as little as 3 hours Learn More Friday Night Lights has five seasons, which present the plot of the drama. The plot of the drama is engaging to viewers. A plot presents incidents of the drama to viewers. It is the structure of the drama. Every episode in the drama has a ‘whole’ element of a plot i.e., beginning, middle, and end. The beginning sets the pace for the rest of the drama. For instance, season one focuses on two crucial events, which are the rise of Coach Taylor to the position of the head coach and the injury of Street. These are events, which affect and lead the first season to its end. They show cause-and-effect chain in the drama. This television series has complete plots to reflect unity of actions. In other words, all episodes structurally self-supporting in which all incidents are bound together through internal action and necessity, which lead to next incidents. However, this television series presents an episodic plot in which episodes succeed one another. It is the events of the play, which tight the play together because they happen to the same characters, who appear in all episodes of the drama. For instance, in episode one, we have Coach Taylor who will take the team throughout the last episode four. One must recognize that events change in every episode. Nevertheless, they happen to the same coach and other characters who appear in all episodes. This brings element of unity in Friday Night Lights. Finally, the plot of the television drama reflects elements of a certain magnitude in terms of length, intensity, complexity, and universal significance. Episodes or seasons in this television are not too brief. The director strived to include several themes in organic unity to enhance the richness and artistic value. For example, in season four, the Coach struggles with undesirable players and dilapidated ground. Vince Howard reflects youth challenges in society and justice while a character like Matt Saracen struggles to find a balance in his life. The episode also reflects grief and loss as Matt struggles to come to terms with the death of his father in Iraq. This episode also shows how Tim Riggins has developed to a reliable and focused character from a hopeless alcoholic. At the same time, the play has universal significant and meaning to many viewers. Hence, the drama is able to capture and hold emotions of viewers. We will write a custom Essay on Is the Television Series, Friday Night Lights Literary? specifically for you! Get your first paper with 15% OFF Learn More The storyline of Friday Night Lights reflects that the work is literary. The director uses a story arc to present the storyline. A story arc applies in a running storyline with episodic plots. It was common in television series, films, or other comic books. The story director explores story details in several episodes and seasons. It is a common method, which drives drama in a story. The storyline is able to attract several viewers and develop fans who follow and discuss different episodes. The development of the storyline raises questions among viewers. For instance, in season two, viewers may wonder whether Coach Taylor would ever return to Dillon after taking a new role as an assistant coach TMU. At the end of the episode, viewers will find a solution to their question as the coach goes back to Dillon. As the storyline develops, viewers also raise questions whether several economic, social, racial, and political challenges that afflict Dillon would end. Viewers also appreciate the importance of football Dillon because it is able to hold the community together. Still, curious viewers would understand how football or sports could highlight social and economic challenges in American societies where football is core. The essay has used characters, plot, and storyline to illustrate that Friday Night Lights is a television series that meets all qualities of a literary work. The process of writing a literary drama is intense, intricate, intuitive, and intimate and sometimes emotional, yet it requires a balance between all these agents of literary styles. The story uses round characters who develop and change as events in the drama unfold. Viewers identify with these characters as they confront and struggle to overcome their daily challenges, desires, and anxieties to change and win. The plot, through episodes and seasons, artistically puts events of the story together for viewers while the storyline maintain coherence of all episodes that make Friday Night Lights. Works Cited Berg, Peter, dir. Friday Night Lights. 2006. Film. Heffernan, Virginia. Friday Night Lights: On the Field and Off, Losing Isn’t an Option. 3 Dec. 2006. Web.