Get help from the best in academic writing.

Parameters of Rocket Nosecone Assembly Project

Parameters of Rocket Nosecone Assembly Project.

I’m working on a aerospace engineering project and need a sample draft to help me learn.

Hi, I need help putting together a nosecone, rocket bulkheads, and coupler for a high powered rocket I am designing. I already have the nosecone and bulkheads, but I do not think they are currently the right size to fit together. The nosecone diameter is 6inches. I would like a full assembly with the nosecone and bulkheads resized to the specifications on the excel sheet, and also a fiberglass coupler put in. The bulkheads can be secured with steel u-bolts. I have attached the nosecone and bulkhead parts and the spec sheet in a zip file. There are different designs bulkheads since I did not know which design would be best.
Parameters of Rocket Nosecone Assembly Project

How are apples and oranges supposed to be compared?. Paper details I’d like to take a philosophical approach to answering this prompt discussing gender equality and gender differences. Both apples and oranges are fruits but are different fruits. Some oranges or apples can possibly look or taste like another fruit but it does not stop them from being who they actually are. I would to take a thoughtful approach backed up by a story that truly matters while staying on the topic of the prompt: comparing apples and oranges.How are apples and oranges supposed to be compared?
Adrian Meadows Black Lives Matter Movement Poster Visual Argument Analysis Essay.

PROJECT ONE: VISUAL ANALYSISTHE PROMPT:In our increasingly visual world, it is important to understand how visual texts do rhetorical work. Just like written texts, visual texts make arguments aimed at particular audiences. The images we see every day (commercials on TV, billboards on the side of the freeway, ads on social media, etc.) are made up of a series of visual strategies tailored to a specific group of people. Analyzing an image involves many of the same procedures as analyzing a written text: specific elements and details of the image are closely examined in order to determine meaning and effectiveness.For this first essay, you will choose a visual text on your own that you think makes an argument and targets a specific audience—this can be a still image, like a picture or poster, or it can be a video, like a commercial, public service announcement, or music video. Once you’ve chosen your text, you will perform a visual analysis, focusing on how this text uses imagery to make a specific argument and whether or not you think this text will successfully persuade its intended audience.THE SPECIFICS:Your introduction should introduce the text you chose to analyze. Make sure to discuss context: who created this visual text, when it was created, who the intended audience is, etc. You should also say what argument you see this text making.Your body paragraphs should closely analyze this visual text, focusing on how you see it making the argument that you discussed in your introduction. In this section, you should break the image down a bit and examine some specific elements of the image (feel free to reference the resources on Canvas). Think about how each of these smaller details of the text helps it to make the argument you described in your introduction.Your conclusion should say whether or not you think this text will successfully persuade its intended audience. So, given the details you discussed in your body paragraphs, will this text do what it was intended to do? This is the place to really evaluate this text and explain your reasoning.REQUIREMENTS:MLA format. This requires: Times New Roman size 12 font, double spacing, 1 inch margins, appropriate heading and page numbers, correct in-text citations, and a Works Cited page.Your rough draft should be at least 3 full pages. Your final draft should be at least 3-5 full pages.
Adrian Meadows Black Lives Matter Movement Poster Visual Argument Analysis Essay

Dighton rock was discovered in river Massachusetts. In the year 1963, it was excavated for storage and later listed among the artifacts in the year 1980 ( par. 23). Dighton rock is sandstone of about 40 tons. It is a six-sided slanting block, approximately 3.4m long, 1.5m high and 2.5m wide ( par. 23). It is classified as an artifact due to the inscriptions found on one side of the rock. The rock has a crystalline, grey-brown appearance. Currently, the rock is located in Dighton museum in Massachusetts and can only be viewed on an appointment basis. The original place where it was found has been converted into a park open to the public (Department of Conservation and Recreation par. 1). This inscription dated back in the 17th century. It has been classified as an important archeological tool. The inscriptions found on the stone are believed to have been made by the Indians according to the 17th century American scholars ( par. 24). Other scholars urge that this historical landmark is linked to Portuguese explorers who visited the Americus. The surface where the inscriptions are located has a trapezoidal countenance inclined at an angle. The stone was found inclined 70 degrees northwest, with the inscriptions oriented towards the waters of the bay ( par. 24). The inscriptions found in the rock were identified to have originated from Portugal by an American scholar in the 20th century. This scholar went ahead to suggest that the tool used to make the inscription to be bug-eyed aliens ( par. 27). The evidence retrieved from the site back the theory suggested by the American scholar. There are many theories that have been put in place to try to explain the origin and meaning of the inscriptions (Massachusetts Historical Society par. 1). Currently, scholars have not adopted any theory as that can be used to explain the mystery surrounding the rock. Artists, on the other hand, have also come up with numerous arguments about the artistic nature of the rock leading to varied explanations about the origin of the art used to decorate the rock (Massachusetts Historical Society par. 10). The most credited explanation on who made the inscriptions goes to Rafn Carl C., the Secretary of the Royal Society of Northern Antiquaries in Copenhagen in the year 1830 who linked the inscriptions on the rock to the Norse explorers who are believed to be among the earliest explorers to have reached North America ( par. 28). Get your 100% original paper on any topic done in as little as 3 hours Learn More The information available about Dighton Rock places it at the center of three important groups in American history (Department of Conservation and Recreation par. 1). These groups are the Portuguese, Indians, and the Norse. This proves that these three groups must have been among the earliest settlers of North America. All these groups of people are linked to this artifact proving that they might have something to do with the artifact or maybe they interacted at the time this artifact was made creating a link of all three groups to the artifact. This artifact can, therefore, be used in the development of American history. As a form of evidence, it can trace the origin of three of the ancient American settlers. Therefore, it is a significant archeological artifact that can be studied and used in explaining the cultural practices carried out by the ancient settlers of the Americas (Massachusetts Historical Society par. 9). The form of communication relayed by the inscriptions on the curving proves the existence of writing skills in the enceinte times. Besides, the message put in the inscriptions is linked to natives and explorers. The most important aspect of this rock is the rich history it carries and therefore, its use in historical studies enhances understanding of the past civilizations. Works Cited Department of Conservation and Recreation. Dighton Rock State Park. 2013. Web. Dighton Rock in Berkley 2003. Web. Massachusetts Historical Society. Seth Eastman on Dighton Rock. 2013. Web. We will write a custom Essay on The Dighton Rock Discovering specifically for you! Get your first paper with 15% OFF Learn More

Tumor Suppressor Gene Therapy for Lung Cancer

Tumor Suppressor Gene Therapy for Lung Cancer. CRITICAL APPRAISAL PAPER ABSTRACT The Tumor Suppressor Gene therapy (TSG therapy) is now available for the treatment of Non-Small Cell Lung Carcinomas (NSCLC), which works on the principle of replacement of mutated or deleted tumor suppressor genes such as p53, mostly found inactivated (50%) in the lung cancer. Clinical trial phase I and phase II study of TSG therapy has shown improved efficacy and low toxicity compared to conventional treatments available for treatment of lung cancer and can restore sensitivity of tumors to chemotherapy and radiation therapy. Trials on tumor suppressor gene therapy started at the end of 90’s, but due to the limitation of gene delivery techniques to transfect only small percentage of tumor cells and having low bystander effect due to this, it requires more time for further improvement and development of new techniques for systemic delivery of genes. According to my opinion, despite this limitation, due to rapid development in gene therapy, these problems will be resolved, and TSG therapy has auspicious future for treatment of lung cancer. INTRODUCTION The aim of this opinion paper is to identify and analyze the advantages and disadvantages of TSG therapy for treatment of lung cancer based on the literature and research articles available till current date and to give an opinion regarding therapy whether it is fruitful or have any drawbacks and its future aspects in lung cancer treatment. Lung cancer is the highly diagnosed and the major reason of death due to cancer in both females and males in Canada. The 5-year survival rate is 14% for males and 20% for females in Canada (1). Lung cancer is divided into two major subtypes based on the type of cell involved: 1) Small-Cell Lung Carcinomas known as SCLC, 2) Non-Small Cell Lung Carcinomas known as NSCLC. There are three subdivisions of NSCLC: 1) Squamous-cell carcinoma, 2) Adenocarcinoma and 3) Large-cell carcinoma and NSCLC is the chief leading cause of the mortality in the world (See Figure 1 Appendices) (2). Risk factors for lung cancer include tobacco-smoking with principal leading cause and others are air-pollution, fuel burning and organic chemical exposure to an environment (3). The tumor Suppression Genes (TSG) regulate cell cycle progress and apoptosis, inactivation or deletion of both alleles of gene induce the formation of the tumor (2). The deletion of both alleles known as Loss of Heterozygosity (LOH), found in deletion of TSG (4). The major TSG found to be inactivated in lung cancer are p53, Rb, P16, FHIT, SMAD1, SMAD2, TUSC2/FUS1(TUSC2), PARD3 (See Table 1 Appendices) (5). TSG therapy works based on the transfer of the single functioning copy of TSG to cancer cells which leads to clampdown of cancerous tumor cells growth by cell-cycle arrest, induction of apoptosis and some clinical trials also shows the existence of bystander effect on neighboring tumor cells (2). Vectors used to transfer the gene includes different viral vectors like adenovirus, retrovirus, adeno-associated virus and non-viral vectors like liposomes, polymers and molecular conjugates (6). SEARCH STRATEGY The information has retrieved from various sources by using different kinds of search strategy. I used Google Scholar, PubMed Central, Leddy library online resources E-articles, ScienceDirect Journals, Springer link, etc. to explore articles and information to justify my opinion regarding the therapy. During my search by using above-mentioned resources, I used different types of search words such as “Tumor suppression gene therapy for lung cancer”, “Future aspects of tumor suppression gene therapy”, “Tumor suppression gene therapy lung cancer review”, “Current approved treatment for lung cancer”, “Types of lung cancer”. In addition, I filtered my search by selecting articles from recent years by using “Since 2017”, “Since 2014” on google scholar, by selecting latest publication date such as 1 year, 5 years on PubMed Central and the same kind of strategy on other resources also to search the latest articles available for therapy. DISCUSSION TSG therapy has several advantages in the treatment of NSCLC over conventional therapy like chemotherapy, surgery and radiation therapy having their low survival rate as well as the failure of conventional therapy due to the resistance of tumor cells with mutated or deleted gene to therapy. It also has low toxicity due to direct intratumor injection to target cells compared to conventional therapy which damage the DNA of replicating tumor cells (7). TSG therapy has some limitations as direct viral vector intratumoral injection is usually not achievable in lungs and therapy is useful in metastatic lung cancer as it is available now only for local application in cancer by using inhalation or intratumoral injection (8). In addition, by using the currently available vectors, it can transfect only a small percentage of tumor cells, having a lack of solid bystander effects (6). Different preclinical and clinical trials of p53 gene replacement therapy in the treatment of NSCLC by using retroviral and adenoviral vector showed mediate tumor regression with minimum toxicity. Moreover, overall the results of phase-1 and phase-2 clinical trials for p53 gene therapy in combination with chemotherapy and radiation therapy in NSCLC have shown increased apoptosis of the tumor cells and increased the sensitivity of tumor cells to radiation respectively (2) (See Table 2 Appendices). Based on review of current literatures available for treatment of lung cancer by TSG therapy, despite some limitation of tumor suppression therapy, according to my opinion, it is good choice for treatment of lung cancer compared to conventional therapy as it causes low toxicity and more specifically act on the targeted cells without damaging to normal cells by proper selection of vectors for transfer of gene into tumor cells and this therapy works better in combination with conventional therapy to achieve better results of treatment. The other therapies approved for treatment of lung cancer are surgery which is a viable option in NSCLC, chemotherapy and radiation therapy. In addition, in past decade, many other drugs approved and are helpful for treatment of NSCLC which includes epidermal growth factor receptor inhibitors like erlotinib, gefitinib, afatinib; anaplastic lymphoma kinase (ALK) inhibitor which includes crizotinib and vascular endothelial growth factor (VEGF) receptor inhibitor monoclonal antibody like bevacizumab; that all are provided improved survival for patients with NSCLC (9). FUTURE DIRECTIONS TSG therapy further requires phase III and phase IV clinical trial study after the success of phase I/II trial of p53 gene replacement therapy by using adenovirus as a vector in NSCLC lung cancer, which will consume extensive time and numbers of patients to establish the effectiveness of treatment. In addition, phase I study of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP):cholesterol nanoparticle encapsulating a TUSC2 expression plasmid vector in stage IV of NSCLC confirms the success of TSG therapy in systematic lung cancer and needs further exploration in that area like new vectors and targeting strategies (2). Moreover, future direction will incorporate the development of additional efficient vectors and use of novel genes for treatment (7). Based on results of preclinical, clinical study and progresses that occurred in last few years in gene delivery system and molecular biology of tumorigenesis, as per my perspective, TSG therapy will be successful in the future and become first-line treatment of lung cancer as an individual treatment or in combination with available conventional therapy because therapy directly attacks the etiology of ailment, but for that it will take a long time for development and commercialization (2). REFERENCES 1) Canadian Cancer Society’s Advisory Committee on Cancer Statistics. (2017). Canadian Cancer Statistics 2017. Toronto, ON: Canadian Cancer Society. 2) Lara-Guerra, H.,Tumor Suppressor Gene Therapy for Lung Cancer

Germination of Seeds: Research on Salinity

essay writer free Germination of Seeds: Research on Salinity. 1.1. Rationale The purpose of this investigation is to develop a more advanced understanding of the germination of seeds. The investigation is worthwhile as it will explain such conditions needed for seeds to maximise germination to allow efficient plant development. This information could help the scientific community know when saline reaches dangerous levels for radish seeds. 1.2. Background Information The aim of this experiment is to find out how the salinity of water affects the optimum germination of seeds. A seed is a small embryonic plant enclosed in a covering called the seed coat, usually with some stored food (“Seed”, 2016). There are mainly two types of seeds: monocots and dicots. The cotyledon in monocots are just thin leaves that usually do not emerge above ground. Dicot cotyledons contain their seed’s endosperm, so they are thicker and fuller, which they use to produce more food in photosynthetic metabolism (Burchill, 2017). In dicots, the primary root first grows upward to the surface and then dives again, while the primary root in monocots grows downward. For germination to occur, the seed requires an adequate environmental temperature, light exposure and a regular intake of water (Burchill, 2017). Germination starts when the seed starts to take up water by osmosis, which is the movement of water through a permeable membrane from higher water concentration to a lower water concentration (“BBC – Standard Grade Bitesize Biology – Cells and diffusion : Revision, Page 4”, 2014). The micropyle, an opening in the testa, or seed coat, allows water to move into the seed causing it to swell and thus rupture the seed coat to allow the embryo plant to emerge (Gillam, 2014). Permeability of the testa is a major factor controlling the rate of water uptake. As seeds imbibe- absorb- water, they expand and enzymes and food supplies become hydrated. Hydrated enzymes become active and the seed increase its metabolic activities to produce energy for the growth process. In addition, the water causes turgor pressure to increase in the cells and they can enlarge. There are three stages to seed germination (“Germination of Seeds: StagesGermination of Seeds: Research on Salinity

Computer Science homework help

Computer Science homework help. Cultural Diversity Scenario (Case Study) Assignment (Worth 10% of Final Grade)Complete and Submit Written Assignment by 2/10, 11:59pm(est).Submit your paper through Turnitin assignment dropbox areaÿ (Failure to do so will cause a ?0? numeric grade).Complete the following written assignment given the scenario (case study) provided. The written assignment is worth 100 points (10%) of your course grade.ÿAÿminimum ofÿTWOÿ(2)ÿreferences are required. References can come from a refereed journal article, course textbook, and or a creditable Internet source.The assignment must be typed on a Word Document with size 12 font, font names that should be used are Times New RomanÿorÿCalabria (not both), normal margins (no more than 1 inch), double spaced. This assignment must be in APA format.ÿThe assignment requiresÿ2-5 pagesÿ(Excluding Title and Reference Page).Scenario (case study)You are the leadership team at your elementary (K-5) school (principal, assistant principal, guidance counselor, and grade level chairs). At the close of the past school year, you learned that your school will have its first wave ofÿBosnianÿimmigrants attending your school this coming fall; these 30 students will be relatively evenly distributed among your six grades, with four to seven students in each class. Your average class size is 25, so these students comprise approximately 20% of each class. In the past, you have had no students in your school from countries or backgrounds other than the U.S. This will be a brand new experience for your students, your faculty and staff, you, and the community.The following should be included in your assignment.Assignment Layout:ÿA. Title Page:Student Name (First and Last), Student Panther ID Number and TitleB.ÿ Plan (Body of Paper):Develop a plan that will address the following:Discuss the following:Suggestions for ?educating? your faculty/staff over the summer concerning the Bosnian culture, how that culture is different from ours, and the types of experiences these children might have encountered in the immigrant camps.Suggestions and discussion for coping with the challenges these students will present to faculty/staff during the upcoming year. Be sure to include approaches to assessment (assignments, exams, etc.) and any curricular adaptations that might have to be made.Suggest and discuss TWO ways to capitalize on this ?opportunity? to engage the faculty/staff/students/community.C. Conclusion:ÿDiscuss the following:Benefits of having others ?not like us? as the focusHow this experience increases our individual/collective worth in contributing to a globalize world (begin with defining the phrase ?culturally competent?)D. References:Provide a separate References page of the sources used for your written assignment (APA format).Two references are required. You can use the course textbook, articles and or any credible resource, etc. as an additional references. ÿMake sure you cite your sources whenever paraphrasing or directly quoting someone else?s work.Grading Rubric:For this assignment the body of your paper should be a minimum of 2-5 fullÿpages (excludes title and reference pages). Each paragraph should consist of 4-6 complete sentences. The assignment must be typed on a Word Document with size 12 font, font names that should be used are Times New RomanÿorÿCalabria (not both), normal margins (no more than 1 inch), double spaced. This assignment must be in APA format.ÿ The assignment requiresÿ2-5 pagesÿ(Excluding Title and Reference Page).Computer Science homework help

case analysis, management homework help

case analysis, management homework help.

D o NOT Summarize – just Analyze! must include an analysis of all potential options laid out in your case study, as well as a final recommendation.Identification of Operations Issues (15%)Identify operations issues that we have discussed during the course of the semester that the company in your case is facing.Analysis and Evaluation of OM Issues (25%)Discuss how the identified issues are affecting the company and what options the company has to address the issues from an operations perspective.Recommendations – Application of theory & analysis and utilizing OM Strategies (35%)Provide clear and actionable recommendations for how the company should address the issues facing them. These recommendations should be based in OM strategies that we have discussed during the course of the semester.using just one resources which is this bookOperations Management: Sustainability and Supply Chain Management by Jay Heizer and Barry Render.I do not need essay paper what I need is analysis and explanation of each part as I mentioned prevesouly
case analysis, management homework help