Here are four individuals telling you their stories of how they became unemployed. In a multi-paragraph essay, apply the theories of unemployment to explain the type of unemployment that each of these individuals is facing and explain which of these individuals qualifies for unemployment benefits:
Two months ago, Marcelle used to work full time in an automobile manufacturing firm. “The factory where I used to work has closed because our market contracted so much, and so I was laid off. This is happening to people all over the country-all you see in the papers is that economic growth has fallen and incomes across the country have fallen. I have been looking very hard for a new job, but have had no luck yet.”
Until last week, Dominic used to work full-time as a hair-dresser in downtown Cincinnati. “I decided to quit my job, because I want to move to New York City.”
Until last month, Francine worked part-time at a ski resort. “Well, it is summer now, and so the resort is closed. I will apply again in the winter when the snow is back. I am not interested in working until then.”
Two months ago, Beauvoir had been working full-time as a secretary. “I was a good typist, but I don’t know how to use a computer. My boss wanted to upgrade the office to computers, and so I was replaced by someone who is computer-savvy. I have been looking for another job, but it appears that I need to learn some computer skills.”
Develop a response that includes examples and evidence to support your ideas, and which clearly communicates the required message to your audience. Organize your response in a clear and logical manner as appropriate for the genre of writing. Use well-structured sentences, audience-appropriate language, and correct conventions of standard American English.
Miami Dade College Macro Economics Essay Questions
FIVE: Geological Structure PaperThe geological structure and sections of the Earth are an important part of Earth science. For this assignment the student will study the history of the Earth, how the Earth was formed/originated, and of what the Earth consists of. Identifying the different parts of the Earth by looking at its structure and how the Earth is divided are included in the study. Read the following site(s): The structure of the Earth | Earthquakes | Discovering GeologyIn Depth | EarthView the video: Inside the EarthWrite a 2-3 page paper covering the following points related to this topic:Describe a recent event in history that has caused a disruption in the Earth.Research a major earthquake or volcanic eruption from recent history.Give a scientific explanation for the causes of the earthquake or eruption.Fully answer the questions: How did this event cause changes in the Earth, and what specific parts were affected?How was mankind affected from this event?Ensure that you use the Paper Writing rubric to guide your efforts and support your work with scholarly academic resources using APA format.
Grace Forecasting of Earthquake & Volcano Seismic Data Geological Structure Ques
Week 1 Discussion: Our Care Culture (graded)
This week’s graded topic relates to the following Course Outcome (CO).
CO1: Applies principles of nursing, theories, and the care philosophies to self, colleagues, individuals, families, aggregates and communities throughout the healthcare system. (PO#1)
Care expressed and practiced in professional nursing models provides a way of looking at the nursing role from the aspect of care. It may seem excessive to consider aspects of caring and compassion in nursing. However, precisely because it IS nursing makes it crucial to our continual progress of defining and upholding one of our central professional principles.
Address each of these items:
Reflect on a caring and compassionate experience with a patient or family encountered in your practice. How was your compassion demonstrated? What other ways do you wish you would have expressed caring?
How does your thinking about compassion expand to include self and colleagues?
Please complete the iCARE Self-Assessment (Links to an external site.) and download for your own use and information. The self-assessment is not a graded item.
need an answer to the question below.
follow the outline and instruction, write a discipline investigation report
follow the outline and instruction, write a discipline investigation report. I’m trying to study for my Writing course and I need some help to understand this question.
In this assignment, you will write an interview report for an interview that I made-up. This report is not a summary or copy of Q&A of the interview, you will read the instructions and requirements carefully below in the pictures to organize your essay.
for this interview, I already have the subject for the interview. She is a career advisor and counselor for the Business department in our university.And I will attach the outline that I have submitted and passed below as well, you need to follow my outline to write this report.
and there is a peer view sheet attached, I think it is helpful to help you to understand this assignment and organize the essay.
the whole interview was all made-up, so this whole report is going to use your imagination and your common sense or experience of what a career advisor would do to finish, you also can do some research to help you to know what career advisor of a university’s daily job. My outline will also help you to shorten this process.
Min. 1300 words with at least 2 resources.
follow the outline and instruction, write a discipline investigation report
Drug-Induced Long QT Syndrome
online assignment help Long QT (LQT) syndrome is a cardiac arrhythmia diagnosis that is reflective of a description found on the EKG (electrocardiography) as well as patient history and family history. It is an inherited cardiac condition that is characterized by genetically encoded abnormalities in cardiac ion channels, namely through sudden cardiac death, various palpitations, and syncope (temporary loss of consciousness induced by low blood pressure). These abnormalities are characterized by delayed myocardial repolarization that leads to varying degrees of QT prolongation and T-wave abnormalities on an EKG. T-wave abnormalities are represented by longer time from Q wave to the T wave, allowing for longer time for the heart to repolarize. LQTS is a rare disorder, with about 1 in 7,000 people possessing the disorder8. This disorder of the heart’s electrical activity can cause severe and sudden arrhythmias in response to stress or exercise, as the ion channels on the heart muscle cells may not function effectively or may be present in small amounts, generated by mutations in genes that code for these channels. Though it can be acquired, such as from various medications and drugs, it is typically genetic and exists in different forms, with LQTS 1, 2, and 3 being the main forms of the disease. Essentially, if the disorder goes untreated, more than half of affected individuals with inherited types of LQTS die within 10 years9. However, if identified early on, certain lifestyles changes and medications can lead to a prolonged lifespan and prevent further complications. Such treatments include avoiding strenuous exercise, incorporating more potassium into one’s diet, taking beta blocker heart medications, and implanted medical devices can control heart rhythms10. LQT is influenced by three major genes: KCNQ1, KCNH2, and SCN5A. Per Dr. Michael J. Ackerman, he states in ‘Genetics of Long QT Syndrome,’ that “These genes account for approximately 75% of the disorder”1. Namely, patients with the disorder exhibit mutations in at least one of the three main genes that encode for the alpha (α) subunits and are critically responsible for the cardiac action potential; KCNQ1 and KCNH2 potassium channels (encoded IKS and IKR, and SCN5A sodium channel (encoded INA). The clear majority of mutations are single nucleotide substitutions or small insert/delitions2. LQT1 is is a subtype of congenital cardiac syndrome and is typically inherited in an autosomal dominant manner, as most patients have an affected parent and it is the most common type of LQT syndrome3. Each child whose parent carries the autosomal dominant gene of the disease exhibits 50% risk of inheriting the pathogenic variant. Autosomal dominant inheritance of the pathogenic variant occurs when mutation occurs in one of the three major genes, namely KCNQ1. This gene codes for a voltage-gated potassium ion channel that is highly expressed in the heart (KvLQT1)4. The product of the KCNQ1 gene produces an alpha subunit that interacts with other proteins, such as the mink beta subunit, to generate the Iks ion channel responsible for the delayed potassium rectifier current of the cardiac action potential5. The 404 kb long gene codes for a 75-kDa protein containing 676 amino acids and is expressed mainly in the heart, kidneys, pancreas, and small intestine. KCNQ1 subunits contain an NH2 terminus, six membrane-spanning segments (S1-S6), a pore loop and voltage-sensing domain (VSD and S1-S4), two cytoplasmic loops (S2-S3 and S4-S5) and a COOH terminus domain. Majority of KCNQ1 mutations are missense mutations (single nucleotide substitutions) or small deletions/insertions that localize to the S1-S6 transmembrane domains. Mutations in the transmembrane, linker, and pore region of KCNQ1 are typically defined as high-probability disease-causing mutations that cause severe cardiac events in younger ages compared to mutations in the COOH terminal region. Essentially, genetic background may have an adverse effect on the severity of the disease. Mutation type, specific location, as well as degree of dysfunction play integral roles in the clinical course of LQT1. Moss reported that LQT1 patients with transmembrane mutations and dominant-negative ion current effects had longer corrected QT interval and a higher frequency of cardiac events than individuals with mutations in other regions. Additionally, hERG (KCNH2) is also another gene that codes for the alpha subunit of a potassium ion channel and mediates the repolarizing IKR current in the cardiac action potential. HERG potassium channels are comprised of four identical alpha subunits, which correspond to the formation of the channel’s pore in the plasma membrane. Each subunit is comprised of six transmembrane alpha helices (S1-S6), a pore helix between S5 and S6 transmembrane alpha helices, and is cytoplasmically located between the N and C termini. The S4 helix contains arginine or lysine amino acid residues, which are positively charged and present at every third position. This is believed to act as a voltage-sensitive sensor, thereby enabling the channel to respond to different voltage changes by inducing conformational changes between conducting and non-conducting states. An extracellular “turret” loop and pore loop exist between the S5 and S6 helices, which loops into the plasma membrane. The pore loop for each of the hERG subunits in a given channel are adjacent to the corresponding loops of the remaining three subunits and collectively yield a region of the channel pore that is selectively permeable. Mutations in this channel that correspond to loss of function can lead to LQT2 while gain of function mutations can lead to short QT syndrome. These clinical disorders are derived from ion channel dysfunction, also known as channelopathies, and can lead to fatal cardiac arrhythmias, due to the disturbances in the repolarization of cardiac action potential. Though these mutations can lead to both long and short QT syndromes, hERG mutations are typically associated with LQTS. Aside from genetic predisposition of LQT, another way of developing this disorder is for it to be acquired. In particular, LQT is induced by a block of cardiac HERG K channels as a side effect of certain prescribed drugs. Induced LQT drugs include: methanesulforanilide (MK-499) which suppresses abnormal cardiac rhythms, cisapride which relieves gastrointestinal symptoms such as acid reflux, and the allergy condition treatment terfenadine. These unfortunate discoveries has become a major factor amongst researchers who are trying to develop new and safe drugs. In regards to induced LQT, the major findings through this research presents that there could be a structural reasoning to why medications that are normally used block HERG but not other channels such as voltage gated channels. An alanine scanning mutagenesis was used to define the the structural ground for the drug block of the HERG channels induced by the MK-499 drug. The binding site is constituted of the amino acids G648, Y652, and F656 on the transmembrane domain surface and pore helix T623 and V625 of the HERG subunit12 that are adjacent to the channel’s cavity. It was also concluded that though other compounds are structurally unrelated to the drug, they induce LQT and were studied as well. This includes the antihistamine terfenadine as well as cisapride, (a gastrointestinal prokinetic drug) and were observed to interact with transmembrane domain amino acids Y652 and F656, yet not with amino acid associated with pore helix, V625. It was noted that the amino acids that were expressed interacted with the aromatic residues of the S6 transmembrane domain, and these residues are specific to eag/erg potassium channels13. It was also noted that other voltage-gated channels have two different amino acids in the analog positions: isoleucine and valine (Ile and Val respectively). Essentially, these findings point towards possible explanation as to how many frequently used medications block and disrupt HERG’s function, while other potassium channels remain unaffected. To study the effects of the various drugs on HERG potassium channel function, John S. et al induced mutations through site-specific mutagenesis. Using SP6 Cap-Scribe16, complementary RNA sequences were generated after linearization expression constructed with restriction enzyme, EcoRI. Xenopus oocytes were isolated and maintained, as well as cRNA injections were performed. Moreover, to measure and record the membrane currents in the oocytes approximately four days after cRNA injection and to account for chloride currents, Cl- was replaced with Mes. Lastly, the molecular model was accounted for by the retrieved 1BL8 KcsA structure from the Protein Data Bank. The structure was utilized as a template structure for the homology model and sequence alignment was utilized to generate the homology model. The first model was utilized for the docking of MK-499, as only slight differences were observed. Essentially, one hundred conformations (low-energy) of MK-499 were generated and other high-scoring dockings exhibited very similar strong π stacking interactions with F656 and Y652 (see images below). References Kannankeril, P., Roden, D. M.,
the short video of the PowerPoint Introduction to Community and Public Health Nursing: a Quick Primer. Answer the questions below in a post to the Discussion Board. Some of the questions below are directly answered in the video while others will need for you to draw inference from the readings in this module and from your own nursing experience.
Next, review all of your classmates’ initial posts and respond to at least four (4) of your peers (look for peers who have not had any comments before commenting on peers who have), commenting on or asking questions about their posts. Be prepared to answer questions and address comments from your peers about your responses as well. How does population-focused practice differ from individual-focused practice? How does a community assessment differ from an individual assessment? Why is a community assessment prior to intervening in a community so important? How would knowing about resources in your community help you as an ac Initial posts should be 300-350 words. Follow up posts should be 100-150 words each. Your posts should be well thought-out, complete sentences that flow in logical order. Respond to at least four peers, offering new perspectives that reflect critical thinking
Microsoft Azure Week 3 Microsoft Dns Servers to Host the Zone Name Discussion
Microsoft Azure Week 3 Microsoft Dns Servers to Host the Zone Name Discussion.
I’m studying for my Computer Systems class and don’t understand how to answer this. Can you help me study?Initial Post:You have been hired as a consultant by Mercury USA, a small logistics company that migrated to Microsoft Office 365. Mercury needs your advice because their Cloud Administrator recently left the company, but she left the credentials and other vital information related to Microsoft 365 accounts was documented.The CEO of Mercury has provided the following information.Microsoft Tenant Name: mercuryusa.onmicrosoft.comProcured 25 Microsoft 365 licensesThe CEO wants you to address the following items.Change the tenant name from mercuryusa.onmicrosoft.com to mercuryusa.comMicrosoft DNS servers to host the zone nameExplain the nature of at least one user account that will have global administrator rights for the Mercury USA tenant.Users who have left the organization still have Microsoft 365 licenses while the new employees do not.Post One (Steven):Change the tenant name from mercuryusa.onmicrosoft.com to mercuryusa.comYou must log into your Microsoft 365 account and go to the Admin center. On the left side find Settings, click it, and then click Domains. This will take you to the Domains page. Here you can add the new domain you want (mercurysa.com), assuming you have already purchased it. If you have not there is an option to buy a domain on the page. When you have added the domain, click it, and set it as the default. You cannot change any names of the domains once they are created, including the initial mecuryusa.onmicoroft.com. (Domains FAQ, 2020) So be sure you have the name you want. Check for typos and foolishness.Microsoft DNS servers to host the zone nameYou must first create the DNS zone you want to host by logging into your Azure portal account and search for DNS zones in the search bar. Click it and the click the create button. Enter the name of your zone, the location of the Resource group, and the name of the resource group. You then retrieve the DNS zone from the All-resources tab and filter by your domain name. (Azure DNS, 2019)Explain the nature of at least one user account that will have global administrator rights for the Mercury USA tenant.Whoever purchases the tenant for Mercury USA from Microsoft will be the global administer by default. (Assign admin, 2020) They are the first and the mightiest. They will have full control over the tenant. This person should be your most trustworthy and knowledgeable administrator. You may assign other users to fulfill administrator roles, including global. But you should limit the number of global administrators for security purposes.Users who have left the organization still have Microsoft 365 licenses while the new employees do not.In order to transfer a license from a former employee to a new one you, as a Global administrator, must remove the license from the former employee. You can now transfer that license to a new employee. If you no longer want to pay for the license you must delete it after you remove it from a user (employee). (Remove or Delete, 2021)Domains FAQ. (December 11, 2020). Domains FAQ. Microsoft 365. https://docs.microsoft.com/en-us/microsoft-365/admin/setup/domains-faq?redirectSourcePath=%252fen-gb%252farticle%252fAbout-your-initial-onmicrosoft-com-domain-in-Office-365-b9fc3018-8844-43f3-8db1-1b3a8e9cfd5a&view=o365-worldwideAzure DNS. (March 11, 2019). Tutorial: Host your domain in Azure DNS. Microsoft. https://docs.microsoft.com/en-us/azure/dns/dns-delegate-domain-azure-dnsAssign admin. (November 3, 2020). Assign admin roles. Microsoft. https://docs.microsoft.com/en-us/microsoft-365/admin/add-users/assign-admin-roles?view=o365-worldwideRemove or Delete. (February 4, 2021). Remove or Delete a former employee. Microsoft. https://docs.microsoft.com/en-us/microsoft-365/adm…Second Post (Austin):Change the tenant name from mercuryusa.onmicrosoft.com to mercuryusa.comUnfortunately it is not possible to change the tenant name. To complete this task the company would have to get a new Microsoft 365 license under the correct tenant name. If the tenant name is already taken than there is a 90 day buffer period before that tenant name can be selected as well. So this means if someone had the tenant name mercuryusa.com as there account name they would have to cancel that wait 90 days at least than the name would become available again (Cawood, 2020) .Microsoft DNS servers to host the zone nameFirst you will want to make sure the DNS zone. This can be searched DNS zones and than select create zone. In the create zone enter the parent name of the zone that you want to create. With the zone created select all resources if there are a lot of resources than you can search for specific recourses that you would like. Next retrieve the name servers from the DNS zone page of the name of your choice (Rohinkoul, 2019) .In the registrar’s DNS management page, edit the NS records and replace the NS records with the Azure DNS name servers.When you delegate a domain to Azure DNS, you must use the name servers that Azure DNS provides. Use all four name servers, regardless of the name of your domain. Domain delegation doesn’t require a name server to use the same top-level domain as your domain.Once this is done you have complete the task.Explain the nature of at least one user account that will have global administrator rights for the Mercury USA tenant.The user that will have global administrator rights by default is the person who signs up for the tenet subscription. Though the global administrator role can be given to other members from the current global admin or privileged role administrators can give roles to new users it is always best to not give out to many global admins as they have administration rights to everything (rolyon, 2021) .Users who have left the organization still have Microsoft 365 licenses while the new employees do not.To get the lenience back that was paid for for the former employee you will need to go to azure admin center, users and select the user that you want to block access to and remove the license from. click on the user and then select the licenses tab and uncheck whatever licenses you want to take away from them, than select save changes. If using group based license than just remove or add the user to the group and the licenses will be assigned or revoked automatically (JoeDavies-MSFT, 2019) .Cawood, L. (2020, September 18). Here’s what happens when you pick the wrong office 365 Tenant name. Vinewave Blog. https://www.vinewave.com/blog/heres-what-happens-when-you-pick-the-wrong-office-365-tenant-name-27b657e8acbd/JoeDavies-MSFT. (2019, September 30). Assign Microsoft 365 licenses to user accounts. Developer tools, technical documentation and coding examples | Microsoft Docs. https://docs.microsoft.com/en-us/microsoft-365/enterprise/assign-licenses-to-user-accounts?view=o365-worldwideRohinkoul. (2019, March 11). Tutorial: Host your domain and subdomain – Azure DNS. Developer tools, technical documentation and coding examples | Microsoft Docs. https://docs.microsoft.com/en-us/azure/dns/dns-delegate-domain-azure-dns#delegate-the-domainrolyon. (2021, February 17). Azure AD built-in roles. Developer tools, technical documentation and coding examples | Microsoft Docs. https://docs.microsoft.com/en-us/azure/active-directory/roles/permissions-referenceRequirements: 250 – 300 words for each post
Microsoft Azure Week 3 Microsoft Dns Servers to Host the Zone Name Discussion