I’m working on a Python test / quiz prep and need guidance to help me understand better.
class LeibenizClass: #creating a leibeniz class# Attributes results = “”# methods def __init__(self,x): #formula for pi value a = 0 n = 0 m = x for i in range(m): a = a + ((-1) ** (i)) * (1 / (2 * i + 1)) a = round(a,3) self.results = str(a*4) def Circumference(self, radius): #Circumference of Circle pi = float(self.results) return round(2*pi*radius,2) def Area(self, radius): #Area of Circle pi = float(self.results) return round(pi*pow(radius, 2),3) def Volume(self, radius): #Volume of Solid pi = float(self.results) return round((4/3)*pi*pow(radius, 3),3) def Surface(self, radius): #Surface of Solid pi = float(self.results) return round(4*pi*pow(radius, 2),3)
Making Class Module Testable Python Programming Exam Practice
Reference Source: Textbook:- Colquitt, J. A., LePine, J. A., & Wesson, M. J. (2019). Organizational behaviour: Improving performance and commitment in the workplace (6th ed). Burr Ridge, IL: McGraw-Hill Irwin. Case Study: – Case: General Motors Please read the case “General Motors” from Chapter 14 “Leadership: Styles and Behaviors” Page: – 469 given in your textbook – Organizational behaviour: Improving performance and commitment in the workplace (6th ed). by Colquitt, J. A., LePine, J. A., & Wesson, M. J. (2019) and Answer the following Questions: Assignment Question(s): 1.Do you think GM can outduel the technology companies for safe autonomous driving vehicles? (1.25 Marks ) (Min words 150-200) 2.Would you consider Mary Barra to be the prototypical transformational leader? In what ways does she fit or not fit that model? (1.25 Marks ) (Min words 200-250) 3.Given GM’s history, why does Barra put a premium on her executives’ leadershipbehaviours? (1.25 Marks ) (Min words 200) Important Note:- Support your submission with course material concepts, principles, and theories from the textbook and at least two scholarly, peer-reviewed journal articles. Part:-2 Discussion Question: Please read Chapter 14 “Leadership: Styles and Behaviors” carefully and then give your answers on the basis of your understanding. 4.Before reading this chapter, which statement did you feel was more accurate: “Leaders are born” or “Leaders are made”? How do you feel now, and why do you feel that way? (1.25 Marks ) (Min words 200-300) Important Note:- Support your submission with course material concepts, principles, and theories from the textbook and at least two scholarly, peer-reviewed journal articles.
MGT 301 SEU Leadership Styles and Behaviors General Motors Company Case Study
Given a population growth of 1.06% and a current estimated population of 7.7 Billion for 2019.1.06% should be expressed as 0.0106 for calculation purposes. To increase by that amount, multiply by 1.0106.Write a Java Program that will predict what year that the world’s population should reach or exceed 10 Billion. Display the estimated population for each year as the loop progresses.If you choose to try this using a ‘float’ or ‘double’ for the population, be sure to display the results in a readable – non fractional amount.If you choose to use the ‘long’ variable type, you may need to append an L to your initial literal value.ie. long myNetWorth = 1_400_500_999L,Note: Display and use complete numbers for these calculations. In other words, do not load 7.7 billion as 7.7, but as 7700000000 – or alternately as 7_700_000_000L.
Brookhaven College Java Programming for The Prediction of The World Population
RESEARCH PAPER topic antidoping
RESEARCH PAPER topic antidoping.
Part 1: Document your Hack within a briefing paper. Include: the event, the technical details of the incident*, impact to the organization, any regulations/policies/or political discussions that may have been generated as a result, and lastly, if you were the organization Chief Information System Officer (CISO), what new safeguards would you implement to prevent this from occurring again in the futurePart 2: Prepare a PowerPoint briefing of your briefMost articles will provide a higher level overview of the technical details of the event. This briefing should include deeper technical research and understanding. There might be a scenario where you will most likely have to speculate on how the attack/incident/event actually occurred to provide the deeper technical details. Document your findings within this professional. Submit only your paper for grading.looking forward to seeing your work , here is some additional notes I received from my professor ” please provide detailed research on the attached vector, impacts, and your advice for countermeasure mitigations”I think he was only referring to this , I believe I already attached this to the assignmentSecurity Briefing 00000001Research a significant cybersecurity breach/incident/event that has occurred within the past year. There must be NO duplicate submissions for this assignment! Once you select your ‘Hack Incident/Breach/Event’ please post it to this weeks discussion board. Once you submit this ‘Hack’ is now taken unless I deny the entry (will update your submission on the Discussion Board).Part 1: Document your Hack within a briefing paper. Include: the event, the technical details of the incident*, impact to the organization, any regulations/policies/or political discussions that may have been generated as a result, and lastly, if you were the organization Chief Information System Officer (CISO), what new safeguards would you implement to prevent this from occurring again in the future.* Most articles will provide a higher level overview of the technical details of the event. This briefing should include deeper technical research and understanding. There might be a scenario where you will most likely have to speculate on how the attack/incident/event actually occurred toprovide the deeper technical details. Document your findings within this professional. Submit only your paper for grading.Part 2: Prepare a PowerPoint briefing of your brief.
RESEARCH PAPER topic antidoping
Social Media Strategy Research Paper
professional essay writers Social Media Strategy Research Paper.
Both social media and the Internet have changed the way that health care organizations market to their target populations. Complete the following:You have been asked by the chief executive officer (CEO) of a local health care organization in your city or town to create a viable social media strategy for the target market. Your strategy should be in the form of a 3-4 page paper, not including title page and reference page.Additionally, he asks that you develop a marketing research tool that will help the organization understand its target market.Use the city data from your Unit 2 Discussion Board assignment to assist you in the creation of the social media strategy.The use of APA Style and at least 3 scholarly references published within the last 5 years is required.
Social Media Strategy Research Paper
Complete Criminal Justice Discussion (CARLA)
Complete Criminal Justice Discussion (CARLA). I need support with this Law question so I can learn better.
Chapter 3: Criminal Justice System in its Environment—Select One Discussion Question Below
Explain how the terrorist attacks on 9/11 affected criminal justice agencies. Include in your discussion the formation of a new government department: Homeland Security.
In your opinion, to what extent has the ‘‘war on terror’’ impacted local law enforcement practices? What is your reasoning?
Identify the economic/political forces that limit the ability of federal agencies to enforce immigration laws.
Identify future environmental changes that will affect the criminal justice system.
Explain how legislator’s personal views on criminal justice issues can frame legislative outcomes. Use the criminal sentencing structure as an example.
Chapter 4: Problem of Communication—Select One Discussion Question Below
As we have seen throughout this chapter, law enforcement agencies, especially intelligence gathering agencies, keep information to themselves rather than share information. Discuss why agencies horde information. If you were giving advice to the director of Homeland Security, what steps would you recommend to promote the flow of vital information among intelligence agencies?
Think about the college class you liked the most and contrast it with a class you liked least. Compare the quality of communication between the two classes. What are some of the barriers to communication that typically emerge in a college course? If you were a professor, what steps would you take to maximize the effectiveness of communication in your class?
How can communication be improved in an organization that is structured in a traditional bureaucratic form? How might computerized communication be utilized to improve the effectiveness of communication in a bureaucratic organization?
What are the drawbacks of computerized information systems? From a management perspective, what policies and procedures could be implemented to assure the effectiveness of computerized information systems?
Discuss the ethical issues involved in sharing information about inmates or supervisees within a criminal justice context. Can all information be shared? What about medical, or HIPPA information?
Complete Criminal Justice Discussion (CARLA)
The Biology of Retinoblastoma
The Biology of Retinoblastoma. The Biology of Retinoblastoma Abstract : Retinoblastoma (RB) is one of the most common intraocular malignancy tumors that occur during childhood and infancy. There are two forms: heritable and non-heritable. The RB gene is located on chromosome 13 and it produces a protein (pRb) responsible for the regulation of the cell cycle. The theory of “the two hits” explains the occurrence of this disease. Several types of mutation can inactivate both alleles of the retinoblastoma gene and therefore cause a tumor. Point mutations are the most commons type of mutations associated with retinoblastoma. According to its size and localization, tumors are classified by groups. The diagnosis of the disease is essentially clinical. Multiple treatments exist such as chemotherapy, laser, radiotherapy, external beam and as a last resource enucleation. Nowadays, clinicians are trying to optimize its treatment by reinforcing the efficiency of directed chemotherapy with minimal side effects. In the future, a better understanding of the molecular biology of retinoblastoma will allow us to improved therapeutic treatments. Introduction : Retinoblastoma (RB) is a disease of early childhood, most of the cases are discovered by the age of 5. It affects the retina of the child in one eye (unilateral) or in both eyes (multilateral). Studies have shown that disease incidence is around 1 in 20000 live births. Overall, 40% of the retinoblastoma patients have hereditary retinoblastoma, the other 60% have non-hereditary retinoblastoma. (In the hereditary form, the two eyes are usually affected whereas in the non-hereditary form only one eye is touched.) In both cases, the most commons symptoms are leukocoria (a white reflex of the pupil) and strabismus (squint eyes). Leukocoria is only visible under certain light conditions. In some cases, parents find out their child have leukocoria by taking pictures of them. Indeed, in case of leukocoria the fight of the flash colours the eye in white instead of red. As for strabismus, it is easy to diagnose and it reflects the weakness of the vision. The people affected by retinoblastoma have an abnormal karyotype, with a mutation of the Rb1 gene in the locus 14.2 of chromosome 13. The earlier the diagnostic of the disease, the more the patient maintains his vision and lives a safe life. The RB1 gene and its protein action on the cell cycle: As previously mentioned, the Rb1 gene is located at the locus 14.2 of the chromosome 13. It is a tumor suppressor gene composed of 27 exons. Tumor suppressor genes encode molecules involved in the regulation of the cell cycle. There are two tumor suppressor genes that regulate directly the cell cycle: the retinoblastoma gene and the p53 gene. The Rb gene produces the Rb protein (pRb) responsible of the regulation of the cell cycle. The cell cycle consists of 4 phases: G1, S, G2, and the mitosis. At the end of a cell cycle the DNA of the cell will be replicated. This process is true for each of nucleated cells of the body. When the cells are not cycling they are at phase G0 so to re-enter the cycle the cells need to received intra and extracellular signals. When the cell reaches the checkpoint G1 to enter the S phase it needs to build the proteins or enzymes necessary for the DNA replication. To do so, the protein E2F, binds to the DNA sequence to allow its transcription. This protein E2F, also called a transcription factor, binds itself to the pRB protein to form a complex (1) The function of the pRB protein is to inactivate the E2F protein in order to stop the replication of the cell DNA, as a consequence, the cell cycle doesn’t reach the G1 checking point. For the cells to divide further, the pRB protein needs to be inactivated. This is achieved through a process called phosphorylation, during which a phosphate group is added to the protein. The transcription factor E2F can then allow the cells to go to the phase S, and controls the rest of the cell division. However, if the gene Rb is mutated, then the pRB protein formed might not be recognized. Therefore, it won’t combined with the E2F protein, and this transcription factor will be allowed to move the cells directly to phase S with an uncontrolled cell division. Mutation In the 70’s Alfred Knudson made a theory called « the two hit » where he proposed that in the inherited form of Rb, one mutation is inherited via one of the parents: this is called the « first hit », and the second occurs in somatic cells. In the non-hereditary form, both mutations occur in somatic cells randomly. The « two hits » means that the tumor formation occurs after two mutations. They are two alleles in the Rb gene in every nucleated cell of the body (2). In the hereditary form, one of the parents carries a mutated non-functioning Rb gene that is transmitted to the child. Every cell of the child’s body will therefore be carrying one faulty copy of the Rb gene. The cells of the child will only develop the tumor after the remaining other normal copy is mutated, which corresponds to the « second hit ». (figure 1) (3) Figure 1: The genetic mechanisms that cause retinoblastoma We can see here that in the hereditary RB, one of the parents has a mutated non-functional RB gene that is transmitted to the child. The remaining correct, or non-altered, copy is then inactivated by a random event (a mutation or an epigenetic event). The cell proliferation will then lead to the development of retinoblastoma. In the non-hereditary form, the person has two normal copies of the gene. Two mutations are required for retinoblastoma to happen, which is rare. In a normal individual, a cell can inactivate one of the two goods copies but this is not enough to lead to retinoblastoma. Source: Molecular Biology of the Cell (6th edition) (3) In the non-hereditary form, one cell inactivates one of its two RB genes. Later on, second hit will inactivate the second good copy of the RB gene, leading to retinoblastoma. In the non-hereditary form, the person has two normal copies of the gene. Two mutations are required for retinoblastoma to happen, which is rare. In a normal healthy individual, a cell can inactivate one of the two copies of its RB gene but as we described before, two mutations need to happen for someone to get retinoblastoma. The occurrence of retinoblastoma both in the hereditary and non-hereditary RB is the result of multiple categories of mutations such as nonsense, frameshift, splice, missense or epigenetic mutations or even to a mutation in the promoter sequence of the gene. The possible mutations are regrouped in the following table: (figure 2) Figure 2 : Genes Mutations in the RB gene The most frequent mutation is a substitution that leads to premature termination or splicing or missense. We can also have deletions mutations or less frequently, insertions. Source : RB1 Gene Mutations in Retinoblastoma (4) The majority of mutations identified in the hereditary form of RB are point nonsense mutations. They are distributed over the 27 exons or in the promoter sequence of the Rb gene. Most of the time there is a point mutation from a C nucleotide to a T nucleotide. A point mutation induces a premature stop codon. In this case, a CGA (Arginine) becomes a TGA (a stop codon). This premature arrest of the making pRB protein results in a shorter protein that may not function. (4). Diagnostic/classification of the disease The diagnostic of a child with suspected retinoblastoma is accomplished by some ocular examination, a test that allows the ophthalmologist to see inside the eye with an ophthalmoscope. An ultrasonography can also help to detect the mass of the tumor. The international system of classification of the retinoblastoma is based on the size of the tumor as well as on its localization. The type of retinoblastoma determines the treatment choice. There are several groups of disease: group A corresponds to a retinoblastoma tumor size of up to 3 mm, group B is for tumor bigger than 3 mm, group C: retinoblastoma with localized seeds, group D: retinoblastoma with diffuse seeds and group E: retinoblastoma that needs enucleation, the removal of the eye (5). Treatments Retinoblastoma has evolved throughout the years. Before it was a deadly childhood cancer, now currents treatments are evolving to provide the best vision possible to the patient. There are several kinds of treatments for retinoblastoma (6). Chemotherapy aims to reduce to a smaller size the tumor so that a laser treatment can then be effective. Laser treatment is generally for tumors that have been shrunk by chemotherapy. The laser is pointed on the dilated pupil using an indirect ophthalmoscope. There are two types of lasers ; one is a 532nM green light and the other is an 810nM infrared light. The second one is preferred to heat the tumor slowly. Cryotherapy is the use of a probe in the sclera of the eye. It produces low freezing temperature to kill the tumor. This is usually used for large peripheral or closed retina tumors. There is also radiotherapy, preferably, used when the tumor is not responsive to any treatments. It uses an external beam therapy or a radioactive plaque and can have important consequences such as other malignancies within the radiation field or dry eyes. Finally, enucleation, the oldest treatment of retinoblastoma, is curative for uniocular retinoblastoma or for the worse bilateral cases. It is reserved for extensive retinoblastoma where there is no hope to keep vision. The eye is removed and sends to histology to study the DNA sequence of the tumor (6). A prosthesis is then inserted to replace the shape of the eye. Future treatment Over the last few years, researchers tried to focus on developing new delivery chemotherapy methods with fewer side effects. For example, they develop techniques based on periocular injections of carboplatin and other agents in order to increase the efficacy of the drug used. One of the most promoting advances is the interventional radiological technique of intra-arterial chemotherapy (IAC). This technique allows the delivery of a chemotherapeutic agent directly into the ophthalmic artery, with few side effects. Current researches are directed towards gene therapy, stem cells and microarray technology to prevent tumor apparition. Conclusion Retinoblastoma is a child tumor that can be genetic or non-genetic: it can affect one or both eyes. The most common symptoms are leukocoria and squint. Nowadays, multiple treatments exist as the choice of therapy depends on the tumor type whether the diagnosis is done early or not. References Yannek I. Leiderman, Szilárd Kiss,Shizuo Mukai, Molecular Genetics of RB1—-The Retinoblastoma Gene, Seminars in Ophthalmology, 2007, 22:4, 247-254, Available from DOI: 10.1080/08820530701745165 Milam A. Brantley, Jr.The Biology of Retinoblastoma