Get help from the best in academic writing.

Law: Sentences to Fix the Imprisonment Term Essay (Critical Writing)

A determinate sentence is one in which the law specifies imprisonment duration. The law defines a range of definite sentences that the judge can issue, upon considering the circumstances of the crime. An example is a law that penalizes heavily anyone convicted of a second felony. These sentences are mostly employed in the war against drugs and crime. An indeterminate sentence on the other hand has no fixed duration. The convict does not know exactly when they will be released (VanDervort, 2000). Such a sentence would be stated as 4 to 10 years. The actual number of years served depends on the convict’s behavior. If he behaves well, the parole board reduces the sentence. Mandatory sentences are those explicitly spelled out by the law. The judge has no power to change any part of the sentence to suit the offender. The sentencing of celebrities and common people is similar. In my opinion, the justice system does not discriminate against the people in the limelight. I would consider the case of Paris Hilton who was sentenced to 45 days in jail. This punishment was fair considering the misdemeanors she had been engaged in. The celebrity also violated the terms of her parole. References Abadinsky, H. (2006). Law and Justice: An Introduction to the American Legal System. New York: Prentice Hall. Calvi, J. V.,
To succeed and remain sustainable in the hospitality industry, an organization should be able to attract a diverse range of clients who may have different income levels. Overall, this necessity is particularly important at the time when various countries struggle with the effects of economic depression. Moreover, businesses should remember that the purchasing power of clients may remain at the same level. Therefore, an organization can decrease the cost of its services because, in this way, they attract a larger number of clients. Such a strategy is beneficial if the company works in developing markets such as China or India. This is one of the approaches that can be adopted by business administrators. To some degree, this method can benefit such a company as MGM Resorts International. To achieve this goal, the management should pay attention to the efficiency of operations and decrease labor costs. This is one of the points that can be made. Finally, the business can lay stress on the yield management, which enables a hospitality organization to adjust to the changes in demand. For example, this approach can assist hotels in minimizing their losses when the number of clients declines. In turn, this method enables businesses to maximize their revenues at the time when the demand for their services increases. On the whole, yield management is based primarily on variable pricing, which makes an organization much more flexible (Bardi, 2011). In addition to that, a company should be responsive to the needs of clients, especially if these people continuously use the services of a hospitality organization. This approach can also benefit a company like MGM Resorts International. Some businesses attempt to move to those countries in which liability laws are lax. One can discuss several cases illustrating this strategy. The most eloquent examples can be derived from the pharmaceutical industry since many companies attempt to India, Eastern Europe, or Africa, because in these regions, there are not many safeguards that can protect patients. This is one of the reasons why many clinical trials are no longer carried out in advanced countries (Dukes, 2005, p. 265). Certainly, such a practice gives rise to various forms of criticism, but it has become very widespread. Additionally, in many cases, companies manufacture products that can give rise to injuries during testing. Such organizations also prefer to work in developing countries. These are the main details that can be singled out. Get your 100% original paper on any topic done in as little as 3 hours Learn More It is vital to understand the intent lying behind the strategic alliance and the causes that underlie the competition between companies. In this way, one can better understand the major goals that these businesses try to attain. Additionally, this knowledge can help a manager predict possible responses to new products or new threats. It should be mentioned that strategic alliances can serve different purposes such as sharing of resources or technologies (Hitt, 2008, p. 247). This approach enables businesses to increase their effectiveness. In turn, potential competitors of the newly created organization should be aware of this risk. One should keep in mind that in some cases, businesses that are usually viewed as competitors can form a strategic alliance. As a rule, such an action can be explained by the willingness of management to change the long-term policies of a business. So, this information should not be disregarded by managers because, in this way, they can make their companies more response. Reference List Bardi, J. (2011). Hotel Front Office Management. New York, NY: John Wiley and Sons. Dukes, M. (2005). The Law and Ethics of the Pharmaceutical Industry, New York: Elsevier. Hitt, M. (2008). Strategic Management: Competitiveness and Globalization, Concepts. New York, NY: Cengage Learning, 2008. Print.
website: Introduction Introduce the topics that you will cover in your paper. Use 12-pt., Times New Roman, double space, and indent each paragraph throughout your assignment. Each paragraph should include a topic sentence, at least 2 qualifier sentences, and a transition, for a total of 4 sentences. Use APA in-text citations where your references are used. Do not change the document margins. The assignment should be 4-6 pages (plus a title page and a reference page). The strategic position for a company, and their goals can be represented by internal and external factors. The Porter’s Five Forces Model is an external model to evaluate the competition in an industry. Using the company you chose, as a consultant, evaluate the industry using the five forces: threat of new entrants, bargaining power of suppliers, bargaining power of buyers, threat of substitute products or services, and existing industry rivalry. Type your response here. Using the same company, apply the internal SWOT model to describe the internal strengths, weaknesses, opportunities, and threats for strategic planning. Type your response here. Summarize two internal core competencies for your company. Type your response here. Be sure to proofread your assignment for organization, grammar, punctuation, and APA style. References Cite 1–3 sources in APA format. The following are some examples of references cited in APA format: Gliddon, D. G.,
The Cell Adhesion Practical. The extracellular matrix consists of many polymeric proteins and polysaccharides that are assembled into an organised meshwork. The extracellular matrix in our own bodies can be found as connective tissues such as bone and tendon. In animals the extracellular matrix forms a structure called the basal lamina. Basal lamina is a thin, tough, flexible sheet of matrix molecules and is essential in underpinning all of the epithelia. The basal lamina separates the cells and epithelia from the surrounding connective tissue and forms a connection between them. A Basal lamina determines the cell polarity, promotes cell survival, proliferation, and serves as a direct route for cell migration. The basal lamina in the extracellular matrix of animals consists of two main classes of extracellular macromolecules: fibrous proteins known as glycoproteins and gylcosaminoglycans which are polysaccharide chains covalently linked to core proteins to form proteoglycans. The matrix applies powerful influences on the cells. These influences are applied mainly through transmembrane cell adhesion proteins that act as matrix receptors. These matrix receptors have a main role in epithelial cells and mediating their interactions with the basal lamina. Many types of molecules can function as matrix receptors. The main receptors on animal cells for binding most extracellular matrix proteins are the integrins. Integrins are a large family of heterodimeric proteins that exist as both alpha and beta heterodimers. Many matrix proteins in vertebrates have multiple integrins. 5 can bind to Laminin and 9 types of β subunits and 24 of α subunits are formed from human integrins. β1 subunits form dimers with 12 α subunits. These subunits are found on all vertebrates and an example of this integrin is the α6β1 Laminin receptor. Fibrinogen is bound by the β3 integrins. These integrins are found on many cells such as blood platelets. Platelets interact with fibrinogen during blood clotting. It is known for α2β1 to bind to collagens, α5β1 binds to fibronectin, and α6β1 binds to laminins. The binding of a matrix component to an integrin can send a message to the inner part of the cell, and this causes the interior part of the cell to send a signal back to the matrix. The extracellular matrix of connective tissues plays an important role in many muticellular organisms. The connective tissue in the matrix is constructed from glycosaminoglycan polysaccharides which form proteoglycans and fibrous proteins such as collagen. The collagen fibres strengthen and help organise the matrix together. The fibrous proteins give the matrix the flexibility. Collagens are secreted in large quantities by the connective tissue cells. A main feature of a collagen molecule is its triple helical structure. The fibrous proteins give the matrix strength and form structures to which the cells can be anchored using glycoproteins such as Laminin and fibronectin that have many binding sites for integrins on the cell surface. Laminin is the first extracellular protein synthesised in a developing embryo. It is made up of three polypeptide chains held together by disulphide bonds. The extracellular matrix also contains noncollagen proteins with multiple domains and specific binding sites for receptors on the surface of cells. These proteins organise the matrix and help cells attach to the matrix. The extracellular matrix components are degraded by proteolytic enzymes called proteases that act close to the cells that produce them. These proteases belong to two general classes: matrix metalloproteases and serine proteases. Matrix metalloproteases depend on bound Ca2 and Zn2 for activity. The matrix metalloproteases and serine proteases cooperate to degrade the matrix proteins collagen, Laminin, and fibrinogen. The adhesion assay to be used in this experiment involves using trypsin. Trypsin is an enzyme used to remove the living C6 glioma cells from the confluent dish. Gilal cells are important cells in the brain. The experiment will use rat tumour cells. The media will be grown in calf serum. The Calf serum contains growth factors which are used for cells to divide and also contains the ECM components such as fibrinogen. Trypsin is dissolved in a solution that contains a divalent cation cheladtum. This will interfere with the calcium and magnesium cations that are important for cell-cell interaction and cell matrix interactions. The cells will be put in suspension to see how they attach to different ECM components and then placed in the two top lanes of a 96 well dish. The first lane will contain Laminin, collagen I, and fibrinogen. The 2nd lane is the control. When matrix components are placed on well they will stick but not all stick this is when BSA is used in second lane. BSA is a protein added to other ECMs to block the sites that the 3 different ECM components haven’t stuck to. (1)(2)(3)(4)(8)(9) Cell adhesion assays are useful in many aspects of cell physiology and the mechanism of the adhesive response itself. Cell Adhesion Molecules (CAMs) are proteins located on the cell surface that are involved with the extracellular matrix (ECM) in the process called cell adhesion. Cell adhesion molecules have been identified from epithelial cells and studies demonstrate the role of extracellular matrix proteins, fibronectin and Laminin in cell attachment to matrix. These proteins contain specific domains which interact with other matrix components such as collagen. Cell adhesion is a complex process that involves molecular interactions and receptor ligand binding. Adhesion assays measure the contacts between a cell and extracellular adhesion proteins and also provide information about the cellular events. Cell adhesion assays are used to test the ability of a cell line to adhere to a subtrate(4)(5). The methods for measuring cell adhesion can be divided into two types. In the first type of methods, cell adhesion is analysed under static conditions. Static assays are used widely to assess the adhesion of different types of cells such as fibroblasts and epithelial cells. This assay describes the cells ability to adhere. This method is simple to perform and provides assessment of the adhesiveness of cells to a defined extracellular matrix substrate for example Laminin. However, static assay methods poorly stimulate adhesion that occurs in blood. Therefore, a second method is used to measure the cell adhesion using flow chambers. The use of flow chambers enables the researcher to stimulate blood flow and to reconstruct cell systems in the presence of shear. Flow chambers are available commercially and most commonly used to study leukocyte adhesion, either with endothelial cells or to substrates purified ligands. The aim of this practical is to perform a cell adhesion assay with 3 different ECM components and to investigate the ability of extracellular components to adhere to c6 glioma cells. (4)(5) Results In the practical there was an experimental error this is due to mixing with serum. Therefore only B9-B12 was used along with other colleague’s results. Trypsin is an enzyme used to remove the living C6 glioma cells from the confluent dish. Gilal cells are important cells in the brain. The experiment used rat tumour cells. Trypsin is a protease used to degrade the ECM proteins. Trypsin is dissolved in a solution that contains a divalent cation cheladtum. This will interfere with the calcium, magnesium cations that are important for cell-cell interaction and cell matrix interactions. Cells are put in suspension to see how cells attach to different ECM components. Discussion From the results it is shown a hierarchy of ECM components can be concluded. Matrix 1 concludes to be fibrinogen; this is because it is the least to adhere with C6 glioma cells. Asano et al,(2004) stated that ‘C6 cells adhered a little more than twice as well to type I collagen as to Laminin’ this can be clearly shown on the bar chart as the two greater bars (matrix 2 and 3) indicating fibrinogen as the least. Results for both individual and model show C6 glioma cells adhered well to both type I collagen and laminin-1 but C6 glioma cells did not adhere well to fibrinogen. A reason to why the C6 glioma cells did not adhere could be that they are derived from glial cells in the rat brain. Cells derived from gilal cells are unlikely to adhere with fibrinogen and therefore unlikely to express integrins which interact with fibrinogen and this can be seen clearly in both model data and own data. A number of integrins require activation to bind their ligand and anchor the cell to the ECM. For example alphaIIb beta 3 integrin from platelets cannot bind to fibrinogen unless the platelets are activated by binding collagen or thrombin in a forming clot. The activation leads to changes in the integrin which are linked to the cytoskeleton remodelling. In both the model data and own matrix 3 shows to have the greatest absorbance and adherence. This is because collagen is the most abundant protein and most of the extracellular matrix is made up of collagen. Collagen shows the most adherences to the cells this is because collagen contains more integrin receptors than the other ECM components. Trypsin breaks down the ECM properties and therefore cells appear separated under the microscope. A reason to a higher adherence to collagen could be trypsin breaks down the collagen components faster than fibrinogen. A low adherence is shown for fibrinogen this is because fibrinogen in the brain is low. Glioma cells originate from the brain and therefore they would not encounter with fibrinogen so the integrins only bind to collagen and Laminin.(3)(2) Another experiment in determining which integrins are important in cell adhesion to the ECM component is using antibodies. Antibodies identify the functions of the ECM receptors in cell attachment and cell migration by attaching to the alpha and beta and are also used to block adhesion to ECM .Blocking the function of the beta subunit inhibited cell adhesion to Laminin and fibronectin. These results were expected because a beta polypeptide can associate with several alphas to form receptors for collagen and Laminin. In the late 80s functionally blocking antibodies were used on α2 integrins to block adhesion to collagens and β1 integrins blocked the adhesion to several ligands. 2 Rat monoclonal antibodies have been used against integrins. Monoclonal antibody (mAb) 13 recognizes the integrin class 1 beta polypeptide and monoclonal antibody 16 recognizes the fibronectin receptor. These monoclonal antibodies were used to test the inhibitory activities in cell adhesion, spreading, and migration using w138 human fibroblasts. It was shown mAb 13 inhibited the attachment and spreading of w138 cells on fibronectin and Laminin substrates. It was shown Laminin mediated adhesion and was sensitive to mAb 13 compared to mAb 16 which showed cell attachment to fibronectin but not Laminin. This shows this receptor is not involved in Laminin cell adhesion. (7) The α1β1 integrin can bind to collagen types I, II, III, and V but favours other subtypes such as type IV and XIII. This is why α2β1 integrin is the major receptor for type 1 collagen. An experiment in determining the collagen receptors is to see the effect of collagenase-cleavage of type I collagen on a2b1 integrin-mediated. Collagenase-3 cleavage of type 1 collagen has shown to have an effect on α2β1 integrin. An isolated α2β1 integrin and α2 integrin A- domain were found to bind native collagen and native k fragment. It was shown integrins were lost after heat denaturation of the collagen fragments and shown human fibrosarcoma cells (HT1080) adhered to type 1 collagen and k fragment at 37°C. HT1080 cells cultured on type 1 collagen and collagen fragments expressed high in α2β1 integrin on cell surface and very little to αvβ3 integrin detected by immunolocalization. This experiment shows that α2β1 integrin binding to type 1 collagen is dependent on the maintenance of the collagen triple helical conformation. (6) Inconclusion integrins are important adhesion molecules involved in cell-cell- matrix adhesions. The Cell Adhesion Practical

BIO 120 Grossmont College Energy and Nutrients Questions Discussion

BIO 120 Grossmont College Energy and Nutrients Questions Discussion.

you have to watch these lectures and answer the questions based on what the professor said in the lecture. all answers should be clear. should answer each question separately and complete the answer. Energy and Nutrients1) What is the Law that requires the continued need to bring energy into an ecosystem?2) On average how much energy is passed on from one level in a trophic structure to the next? How does eating meat impact your biological footprint given this information?3) Which terrestrial and which aquatic ecosystems are the most productive when measuring within a square meter in a year?4) What is the equation for most of the primary production on the planet earth?5) In modern societies, what is the pathway of nutrients starting on a farm and what happens to those nutrients, in most cases, as they go through the average consumer process? How do most farmers maintain their nutrients on their farms?…… PreviousNext…
BIO 120 Grossmont College Energy and Nutrients Questions Discussion

University of the Pacific Apple Inc Corporate Social Responsibilities Paper

write my term paper University of the Pacific Apple Inc Corporate Social Responsibilities Paper.

21st Century Corporate Social ResponsibilityPrior to beginning your assignment, read Chapter 2 of the textbook and Corporate social responsibility in the 21st century: A view from the world’s most successful firms. Using the Fortune 100 List (Links to an external site.), choose an organization that has their corporate social responsibility (CSR) statement, vision, and mission statements available on their website. Quote the statement and describe what this means in your own wordsResearch a recent article on the organization that is related to their current and/or future CSR activities.Describe how the new plans will affect the organization, both internally and externally. Develop an idea for a new CSR endeavor for the organization based on the organization’s mission and vision. The paperMust be three to four double-spaced pages in length (not including title and references pages) and formatted according to APA style as outlined in the Ashford Writing Center (Links to an external site.).Must include a separate title page with the following: Title of paper Student’s name Course name and number Instructor’s name Date submittedMust use at least one scholarly source in addition to the course text and the article by Snider, Hill, and Martin (2003).Must document all sources APA style as outlined in the Ashford Writing Center (Links to an external site.).Must end with a conclusion that clearly summarizes what was presented in the paper.Must include a separate references page that is formatted according to APA style as outlined in the Ashford Writing Center (Links to an external site.).Carefully review the Grading Rubrics (Links to an external site.) for the criteria that will be used to evaluate your assignment.
University of the Pacific Apple Inc Corporate Social Responsibilities Paper

Santa Monica College Elizabeth Mock MOMA Curator Bibliography Paper

Santa Monica College Elizabeth Mock MOMA Curator Bibliography Paper.

Hi, I need someone who can write 10-12 minute presentation related to the lecture topic and/or the readings.This assignment has 2 parts:1- Bibliography as soon as possible. ( It should show The bibliography should contain at least 5 scholarly references, follow the Chicago Manual of Style, and be listed on the last page of the presentation. Citations from scholarly sources should be used in the presentation to make an argument.2- Actual presentation that you will have a week to complete it, I will extend the time after you submit bibliography. (With Pictures)Choose one of the topic below (You need to focus on the roll of the women in the movement)Magda Cordell McHale, founding member of the Independent GroupDorothy Morland, ICA director Sarah Jackson, artist (with Emilio Scanavino formed group four in the exhibition This is Tomorrow at the Whitechapel Art Gallery)Alison SmithsonJane Drew Mary Jane Long, or MJ Long (American architect), partner with Colin St. John WilsonMary Banham (if enough research is available) Sadie Speight (British architect) and her husband, Leslie Martin, wrote two important design books, Everyday Things, 1931, and The Flat Book, 1939.Brackenfell (formerly Morton House), Brampton, Cumbria, UK,1938. Sources: Anne Massey, “The Mother of Pop? Dorothy Morland and the independent Group,” Journal of Visual Culture, 2013. Louise Campbell, “Constructivism and Contextualism in a Modern Country House: The Design of Brackenfell (Leslie Martin and Sadie Speight, 1937-38)”Elizabeth Mock (MoMA curator)
Santa Monica College Elizabeth Mock MOMA Curator Bibliography Paper

GLST 290 Liberty University

GLST 290 Liberty University. I’m stuck on a Writing question and need an explanation.

A cross-cultural worker living abroad can be totally absorbed and integrated into the culture of the people with whom he or she ministers. Why or why not?
This is just a Discussion Board Question.

Post your initial response to various questions in a post consisting of at least 250 words* using Scripture and course materials found in the Reading & Study folder.
Cite all material used in your posts and replies using current Turabian formatting

GLST 290 Liberty University

Essay Writing at Online Custom Essay

5.0 rating based on 10,001 ratings

Rated 4.9/5
10001 review

Review This Service