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Finance course

Finance course. I’m studying for my Accounting class and don’t understand how to answer this. Can you help me study?

The textbook mentions the agency problem wherein managers do not act in the best interest of their principals. Discuss what the agency problem means for firms in Saudi Arabia, especially in the context of Saudi Vision 2030, and whether you have experienced any examples of the agency problem.
Search the SEU library or the Internet for an academic or industry-related article regarding this thesis, as well as its implications for Saudi Arabia and Saudi Vision 2030.
For your discussion post, your first step is to summarize the article in two paragraphs, describing what you think are the most important points made by the authors (remember to use citations where appropriate). For the second step, include the reference listing with a hyperlink to the article. Do not copy the article into your post and limit your summary to two paragraphs. Let your instructor know if you have any questions and enjoy your search.


Finance course

SNHU Scientists use Revolutionary Gene Editing Tool To Edit Inside A Patient Article Discussion.

For this module’s discussion, research a recent science news event that has occurred in the last six months. The event should come from a well-known news source, such as ABC, NBC, CBS, Fox, NPR, PBS, BBC, National Geographic, The New York Times, and so on. Post a link to the news story, and in your initial post, identify the following:Summarize your news story and its contributions to the science or STEM fields.If your news event is overtly related to popular culture, how does this event contribute to popular culture studies? If your news event does not directly relate to popular culture, how could the science behind your event be applied to popular culture artifacts?In response to your peers, provide feedback about their news story and describe the value of the science lens for understanding popular culture.
SNHU Scientists use Revolutionary Gene Editing Tool To Edit Inside A Patient Article Discussion

For a long period, Pakistan and the United States of America have been two nations that traditionally co-existed in peace and harmony. The two countries have always stood up for each other in the face of hardships such as wars or floods. As a matter of fact, there are absolutely no records of any war that ever took place between the United States of America and Pakistan. This paper is about factors that have been driving a wedge into the relationship of these two countries. While some of these factors are internal or arise within the two countries, some of them are external forces that are beyond the reach and control of the two countries. In the last one or two years, the relationship between Pakistan and the USA has been torn apart by political issues and differences. One such difference is the dealing with terrorist groups and militia men who are causing turmoil in the Middle East. These groups include the Taliban and the Haqqani network. These groups have engaged in destructive acts that have created a big impact to the nation. Not only have such acts shaken the economy of the country but the political arena as well. The citizens are in constant fear due to the numerous threats issued by these groups. The question that that begs to be answered is who is to blame and why? The author of this essay strives to illustrate the point that the accusations heaped upon Pakistan by the United States of America are true. The author will achieve this by writing a commentary on an article that appeared in the New York Times on the 6th of October, 2011. The author will also rely on two other sources to further point out the fact that Pakistan is indeed responsible for much of the turmoil going on in the Middle East. Gladstone (2) argues that the Pakistan’s support of unlawful terrorist groups such as the Taliban and the Haqqani have undermined the efforts of the United States of America to restore peace and calm in the Middle East. For instance, the alleged supply of arms and ammunition by the Pakistani to the militia groups in Afghanistan has frustrated efforts to restore law and order in the region. This is because the terrorists receive support from the Pakistani making them equally powerful and dangerous against the American and the United Nations troops. The major allegation ever made against the government of Pakistan is that it was involved in covering up the exact location of Osama Bin Laden, the then Al-Qaeda leader. This was a major shock to the international community. Whether this allegation was true or false remains a mystery, but the probability that this was the case before the death of the terrorist is high. Get your 100% original paper on any topic done in as little as 3 hours Learn More This is because quite a good number of substantial evidence confirms this. An example of this is the fact that the Pakistani community and even some local people to some extent knew the whereabouts of Osama Bin Laden. However, most of them could not disclose any information to anyone because they feared for their lives. Considering the fact that Pakistan has been the main cause of alarm in the Middle East, one would think that in order to command such respect, the country must be having a good fortune. However, this is not possible. Virtually all the buildings in the small towns of Pakistan have been brought down by war (Ahmed 5). Most former inhabitants of these ruined cities have made their way to other better places to live. A preferred destination for the emigrants has always been the neighboring Arab countries. This is because they don’t face any religious hostility. After discussing the role of Pakistan in the prevailing war in the Middle East, it now becomes necessary to look at the measure that can be taken against this country in order to stop it from promoting any more crime. In this case, it would be effective if this country would receive sanctions banning it from trading with any other country in the whole world. This act of punishment will lead to inadequacies in the country which may prompt the government to hold their horses for the sake of peace. But it is not what should be expected. Having known the Arabs only too well, it is most likely that they will keep on fighting to the last man. If anything, the sanctions imposed upon them will only aggravate them and cause them to seek for revenge. Another possible act of punishment would be to ban all travel into and outside of the country. Under normal circumstances, this step will certainly be a big blow to the Pakistanis. However, since Pakistan is a non-tourism country, it stands to lose nothing (Steven 24). This travel ban will only affect a handful of Pakistanis who are probably engaged in international trade or those who plan on visiting their loved ones in foreign countries. However, the most ironic part comes in when the United States of America, after having a hard time dealing with Pakistan, still takes no disciplinary measures against them. It would be expected that the USA would take stringent measures to make the Pakistanis pay for all the pain, harm and loss of lives and property that they have had a hand in causing. Instead of disciplining them, the USA does an even more astonishing thing. Currently, the United States of America spends billions of dollars in military and civil aid to Pakistan. We will write a custom Essay on Pakistan Versus The USA specifically for you! Get your first paper with 15% OFF Learn More The President of the United States of America, Barrack Obama, holds the view that it would be unfair to punish vulnerable Pakistanis such as flood victims because of poor decisions made by their leaders and most specifically, their intelligence services (Gladstone 56). However, it is a pity that the Pakistanis authorities have failed to acknowledge this immense gratitude bestowed unto them. Instead of seeing to it that every flood and war victim has what she or he needs, they are engaged in other activities that will only worsen their situation. From the foregoing, it can be seen that Pakistan has been actively engaged in activities that have facilitated war or even created a conducive environment for war. It has been a major role player in the never-ending conflict in the Middle East. It has also been more of a war maker than a peace maker. This is because it has allied with terrorist groups such as the Taliban and the Haqqani network. It can also be seen that although there is enough evidence suggesting that Pakistan has been involved in terrorism activities, no disciplinary measures have been taken against it. Instead, the United States of America has faithfully stood with the country even as it is faced with life-threatening floods. All in all, there is need for the Pakistanis to join hands, say no to terrorism and aim at building up a politically and economically stable nation. Works Cited Ahmed, Akbar. “A Third Encounter of a Close Kind,” History Today 39 November 1989: 4-9. Print. Gladstone, Rick. “Obama warns Pakistani on militants” The New York Times 6 October 2011: 56-57. Print. Steven, Philip. The Idea of Pakistan. New Delhi: Brookings Institution Press, 2004. Print.
FNU Wk 7 Validity & Trustworthiness of Qualitative Nursing Research Discussion.

I’m working on a nursing discussion question and need guidance to help me learn.

Chapter 10: ValidityChapter 11: Trustworthiness of qualitative researchRead
Chapter 10 & 11 Discussion
# 4Based on your readings, please answer the following discussion
question.What are the perceived challenges do you expect to find with
validity and trustworthiness in qualitative research? What steps will you
implement to ensure that your research is reliable?APA style250 wordsResources must support your statements.intext citationreference page Ruth M. Tappen. (2015). Nursing Research. Advanced Nursing Research: From Theory to Practice. (2nd ed.). ISBN-13: 9781284048308. ISBN-10: 1284048306. Publisher: Jones & Bartlett Learning
FNU Wk 7 Validity & Trustworthiness of Qualitative Nursing Research Discussion

PU Police Theory & Practices Decision Discretion & Accountability Presentation

PU Police Theory & Practices Decision Discretion & Accountability Presentation.

I’m working on a writing question and need guidance to help me learn.

Make a powerpoint presentation of minimum 10 slides (not counting title and references slides), and make sure to add 100 words in the speakers notes to each slide. please see attached files for instructions Assignment ContentReview the PowerPoint Example located at the top of the course content page under the folder labeled Recommended Reading and Handouts.A decision tree is a great way to determine a course of action and possible outcomes associated with an officer’s decision. Today everyone has a camera and decisions are reviewed, questioned, and judged by those who have no idea what happened. In Ch. 5 you learned about tactical decision-making and scenario-based training for new officers. Discretion is a major part of a police officer’s role and the decision he or she makes in a split second can create many different outcomes and consequences. Watch the Decision Tree video located in the University Library.Read the Sidebar 11-1, “Police Discretion in an Unfolding Disturbance Call” in the “New Perspectives on Police Discretion” section of Ch. 11, “Police Discretion,” of The Police in America.Consider the different stages the officer is faced with in the scenario.Select stage four, five, or six and review the officer response provided.Create a 10- to 12-slide Microsoft PowerPoint® presentation in which you:Describe possible decision points that the officer may have faced.Explain how one decision the officer could have made modeled abuse of discretion or modeled positive use of discretion.Describe factors that may limit the officer’s discretion.Explain at least three internal and external mechanisms police departments use for accountability.Incorporate one citation/reference from the course textbook and at least two academic citations/references outside of your textbook in your presentation. An academic reference is a source from Electronic Reserve Readings, UOP Library, Google Scholar, eBook Collection, or course reading assignments.Provide examples to support your points in the presentation.Presentation should include a title slide, introduction slide, research slides, conclusion slide, and a reference slide. (The Title Slide and Reference Slide do NOT count towards the slide count requirement.) A 10 – 12 slide PowerPoint Presentation should average between 800 – 1,000 words of research.List major points on the slides using bullet points which are limited to approximately five lines; approximately five words per bulleted item. Add a paragraph (approximately 100 words) to the speaker notes to support the bullet points with a citation to give credit to the source. (See Rubric) Speaker notes are not required on the Title or Reference Slide.Microsoft Support has some great instructions and a video on how to create speaker notes for PowerPoint.Include videos, audio, photos, diagrams, or graphs as appropriate.Submit your assignment.If you do not have Microsoft® PowerPoint® installed on your computer, you can download and install Microsoft Office 365 for free.ResourcesAssignment Grading GuideCenter for Writing ExcellenceReference and Citation GeneratorGrammar Assistance
PU Police Theory & Practices Decision Discretion & Accountability Presentation

Formulation of ointment and cream

essay writer free Effects of Pure and Mixed Homologue Alcohols on Non-ionic Creams 1. Introduction 1.1 General introduction of emulsions Emulsions are mixtures of two or more immiscible constituents with the interface being stabilized by the addition of emulsifying agents which may consist of ionic or non-ionic surfactants and fatty alcohols. [Eccleston, 1997; Eccleston et al., 2000] There are two different phases can be found in emulsions, with droplets of one phase dispersed in another phase, termed as dispersed phase and continuous phase respectively. Different types of emulsions like water-in-oil (w/o), oil-in-water (o/w) emulsions or multiple emulsions (w/o/w or o/w/o) can be formed, depending on the nature of the dispersed and continuous phase. [Buszello and Muller, 2000] The thermodynamically unstable structure of emulsions can be stabilized by adsorption of surface active agents at the interface, which work by lowering the interfacial tension to decrease the likelihood of collisions between droplets and hence prevent coalescence. This is important in maintaining the droplets in a dispersed state. [Florence and Attwood, 2006] Figure 1 showed the two different ways of surfactant adsorptions at the interface, i.e. monomeric and micellar adsorption. [Rowe, 1965] 1.2 Structure of creams Creams can be described as semisolid emulsions with a relatively fluid viscosity in the presence of excess emulsifiers as these emulsifiers interact with other components in either continuous phase or dispersed phase of emulsions. From the perspective of pharmaceutical and cosmetic industry, the uses of creams are related to their structure properties and they are commonly used as drug delivery agents and cosmetic agents to the skin. [Eccleston, 1992; Eccleston, 1997; Eccleston et al., 2000] These have been shown in the studies carried out by Schwarz, Weisspapir and Friedman which indicated that the efficacy of topically administrated diazepam, in the form of emulsion cream, depends greatly on the size of oil droplet and to a lesser extent on the type of oil used and formulation composition. These also implied that emulsions can be used as transdermal delivery vehicles of diazepam to generate significant systemic effect of the drug. [Schwarz et al., 1995] There are two different types of creams which known as aqueous creams and oily creams. Aqueous creams are the oil-in-water (o/w) types of emulsions which are non-greasy on use, easily to be spread on skin and tend to produce cooling sensation at the site of application. On the other hand, oily creams are the water-in-oil types (w/o) of emulsions which are less popular than aqueous creams because of the potential of generating greasy feel and sensitization on use. [Buszello and Muller, 2000; Eccleston, 1997; Eccleston et al., 2000]. Thus, aqueous creams are more acceptable than oily creams. It was proposed that there are four different phases present in aqueous creams, i.e. a hydrophilic gel phase, a bulk water phase, a lipohilic gel phase and a dispersed oil phase. This four-phase system was known as gel network system. Further details was discussed under section 1.3.4 [Junginger, 1997] Therefore, it can be anticipated that an understanding of complexity and variability of the structure of aqueous creams is essential in characterizing and optimizing specifications of creams to improve the quality of formulated products and hence enhance dermatological drug delivery. 1.3 Emulsifying agent Emulsifying agents are generally surface-active agents that are exploited during the time of manufacture to enhance emulsification and also to confer long-term stability to products like pharmaceutical creams throughout their shelf-life. All these can be achieved by adsorption of emulsifying agents at the emulsion interface to decrease the interfacial tension and to produce repulsive forces between droplets. [Eccleston, 1992; Florence and Attwood, 2006; Rosen, 1978] As a result, the strong van der Waals forces of attraction between droplets when they come close together are counteracted by these repulsive forces leading to the prevention of coalescence of droplets. In addition, emulsifying agents also play an important role in controlling the rheological properties of formulations by interacting with other components in the system. [Eccleston, 1992; Florence and Attwood, 2006] In practice, combinations of emulsifying agents are often used and they are normally consisting of ionic or non-ionic surfactants and lipophilic fatty amphiphiles like fatty alcohols or fatty acids, can be described as mixed emulsifiers. Moreover, the emulsifying waxes are commercial blends of mixed emulsifiers in which the weight ratio of fatty amphiphile to surfactant is nine parts : one part in the mixtures. Example of emulsifying waxes including Emulsifying Wax B.P. and Cetrimide Emulsifying Wax B. P. C. [Barry, 1971; Eccleston, 1997] Table 1. Examples of commonly used surfactants and fatty amphiphiles. [Eccleston, 1992; Eccleston, 1997] Surfactants Fatty amphiphiles Sodium lauryl sulphate Cetostearyl alcohol Cetrimide Cetyl alcohol Cetomacrogol 1000 Stearyl alcohol PEG 1000 monostearate Glyceryl monostearate Triethanolamine stearate Stearic acid Sodium stearate Phosphatidylcholine Table 2. Examples of commercial and pharmacopoeial emulsifying waxes with respective components. [Eccleston, 1992; Eccleston, 1997] Emulsifying wax Components Emulsifying wax BP Cetostearyl alcohol, sodium lauryl sulphate Emulsifying wax USNF Cetyl alcohol, polysorbate Cationic emulsifying wax BPC Cetostearyl alcohol, cetrimide Glyceryl monostearate S.E. Glyceryl monostearate, sodium stearate Cetomacrogol emulsifying wax BPC Cetostearyl alcohol, cetomacrogol 1000 Polawax Cetyl alcohol, non-ionic surfactant Lecithin Phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid 1.3.1 Schulman and Cockbain theory Nowadays, many pharmaceutical literatures reviewed and cited the classical works of Schulman and Cockbain which published nearly 70 years ago as the emulsifier mixtures (combination of ionic surfactants and fatty alcohols) studied are similar to ionic emulsifying waxes that are currently used in formulations. [Eccleston, 1992] According to Schulman and Cockbain theory, it was revealed that molecular interactions arising at a “nujol” (oil-droplet)/ water interface were correlated with the molecular interactions at an air/water interface which had been investigated by Schulman and Rideal in 1937. In this context, the stability of interfacial film of “nujol”-in-water emulsions was running correspondingly to the stability of the monolayer interfacial film at the air/water interface which normally composed of a stable complex of two components, i.e. oil soluble substance and water soluble substance. The stability of this condensed interfacial film at air/water interface depends upon the interactions between polar head groups of the components and van der Waals forces of attraction between the respective non-polar parts. Thus, the changes in nature and stereo chemical properties of the components may result in alteration of molecular packing and stability of interfacial films which in turn influences the stability of “nujol”-in-water emulsions, as shown in Figure 2. Hence, it can be concluded that the understanding of the nature and properties of complex film at the air/water interface is important in deducing the stability of emulsions. [Schulman and Cockbain, 1940] The greater stabilities of the mobile model emulsions were described in Schulman and Cockbain’s publications, however, the detailed mechanism of stabilization of an emulsion was not explained evidently. Thus, Schulman and Cockbain theory cannot be directly imposed into the manufacturing of pharmaceutical emulsions in which the presence of excess emulsifiers above that necessary for a monolayer film, interact with other constituents in the system, either at the droplets interfaces or in the bulk water, to produce a complex multiple phase formulation. [Eccleston, 1992; Schulman and Cockbain, 1940] 1.3.2 Non-ionic surfactants Surfactants, which are one of the constituents of emulsifiers, can be classified into three different categories, such as ionic surfactant, non-ionic surfactant and amphoteric surfactant. Non-ionic surfactants would be the main focus in this study. Non-ionic surfactant is the largest group of surfactant if compared with anionic, cationic surfactant and amphoteric surfactant. This group of surfactant does not bear any charge on their molecule and they are less irritating to eyes and skin if compared to anionic or cationic surfactant. Proportions of hydrophilic or hydrophobic groups in the non-ionic surfactant molecule are crucial in determining the characteristics of this group of surfactants. Generally, the hydrophobic part of molecules contains saturated or unsaturated fatty acids or fatty alcohols whereas the hydrophilic part of molecules includes the polyoxyethylene, polyoxypropylene or polyol derivatives and the hydroxyl group. Compounds with a wide range of hydrophilic-lipophilic balance (HLB) can be obtained by varying the number of hydrophilic groups or the length of lipophilic chains in the molecules. [Nielloud and Marti-Mestres, 2000] HLB system is a system invented about 60 years ago by William C. Griffin and it was developed for the use with non-ionic surfactants. All non-ionic surfactants have an HLB value. The HLB values signify an empirical numerical correlation of the emulsifying and solubilizing properties of different surfactants. The higher the HLB number, the more hydrophilic the surfactants; The lower the HLB number, the more lipophilic the surfactants. In other words, the HLB number is an expression of the percentage weight of the hydrophilic portions calculated theoretically from molecular weight. In addition, emulsions and emulsion applications have specific HLB requirements. Therefore, emulsions with optimal performance can be yielded by matching the HLB requirement with the surfactant’s HLB value. This correlation can be obtained by performing direct experimental tests, though for some systems the HLB value can be estimated by empirical rules from the analysis of the surfactants. [Davies, 1957; Eccleston, 1992; Griffin, 1949] Table 3. Classification of emulsifiers according to HLB values [Davies, 1957; Eccleston, 1992; Griffin, 1949] Range of HLB values Emulsion Application 0-3 Antifoaming agents 3 – 6 Water-in-oil emulsifier 7-9 Wetting agent 8-18 Oil-in-water emulsifier 13-15 Detergent 15-120 Solubilizer In this investigation, polysorbate 60 (Tween 60) was used. Polysorbates are complex mixtures of partial fatty acid esters or sorbitol and its mono- and dihydrides copolymerised with approximately 20 moles of ethylene oxide for each mole of sorbitol and its anhydrides. The polysorbates are miscible with water as reflected in their higher HLB and are used as emulsifying agents for o/w emulsions. The HLB value of polysorbate 60 (polyoxyethylene (20) sorbitan stearate) is 14.9. [Florence and Attwood, 2006] 1.3.3 Fatty alcohols Fatty alcohols are generally functioning as a relatively weak emulsifier when they are used alone to produce unstable and fluid water-in-oil type of emulsions. However, the most commonly used emulsifiers could be formed from the combination of fatty alcohols and ionic or non-ionic surfactants. As for cetostearyl alcohol BP, it is a mixed homologue alcohol as it composed of mixture of cetyl and stearyl alcohol with the weight ratio of six to one. This homologous admixture was presented in excess which gave rise to a ratio of nine parts by weight of fatty alcohol to one part of ionic surfactant or four parts of fatty alcohol to one part of non-ionic surfactant. [Eccleston, 1997] The pure long chain alcohols exhibited marked crystalline polymorphism as normally they presented in three forms such as a-form, ß-form and ?-form. In addition, a-crystalline polymorph was able to create a hydrated crystal in the presence of water via mechanism of limited swelling, as shown in Figure 3. At room temperature (25?), mixed homologue alcohols like cetostearyl alcohol existed in a stable a-modification form whereas pure alcohol such as cetyl or stearyl alcohols in water existed in the form of ß and ? crystals. [Eccleston, 1997; Yoon et al., 1999] This indicated that homologue admixtures are more preferable in producing stable emulsions if compared to pure fatty alcohols. 1.3.4 Mixed emulsifiers with gel network system The consistencies of emulsions are controlled by the concentrations of mixed emulsifiers in a direct proportional manner where at low concentrations of mixed emulsifier, the emulsions formed are liquid and mobile while at moderate or high concentrations of mixed emulsifier, a semi-solid emulsions can be formed. This process can be known as a “self-bodying” action. [Barry, 1971] In general, mixed emulsifiers are needed in stabilizing oily dispersed phase with continuous phase in the system. When the presence of these emulsifiers is surplus to requirements, they interact with each other to form a viscoelastic gel networks in the continuous phase. The formation of this gel networks is related to the stabilities, physico-chemical and rheological behaviours of emulsions. The theory evolved is known as gel network theory. This gel network theory was a result of the study of the types of interaction between surfactant, fatty amphiphile and water of a ternary surfactant-water-amphiphile system. [Eccelston, 1997] Furthermore, the properties and phase behaviours of a range of concentration of mixed emulsifiers and their components in water (ternary system) both below and above the phase transition temperature were investigated and exploited as structural models for the continuous phase of emulsions. [Eccleston et al., 2000] Moreover, it was proposed that the gel network system of non-ionic semisolid cream consisted of four main phases with the similar structural elements as the ionic cream, i.e. a hydrophilic gel phase composed of a hydrated lamellar mixed crystals formed by non-ionic surfactant and fatty alcohol with the incorporation of interlamellarly fixed water, a lipophilic gel phase created mainly by the surplus of fatty alcohol, a bulk water phase and a dispersed oil phase, as shown in Figure 4. [Junginger, 1997] The swelling properties of gel network system depend on total water content and the chain length of polyoxyethylene (in the case of non-ionic polyoxyethylene surfactant) of the system.[Junginger, 1997] According to study of Junginger, with a non-ionic hydrophilic cream ( PGM20(polyoxyethylated-20-glycerol monostearate) -cetostearyl alcohol -water system ) , at a water content less than 25% w/w, the degree of swelling is minimal due to the inadequate hydration of polyoxyethylene chains of non-ionic surfactant. On the other hand, at a water content more than 60% w/w, the hydrophilic gel phase of the system becomes unstable because of the excess swelling. Thus, the optimal water content must be in the range of 25-60% w/w in order to allow the continuous swelling of hydrophilic gel phase of the system. [Junginger, 1984] Moreover, the chain length of polyoxyethylene of surfactant influences the ratio of interlamellarly fixed water and bulk water in the system. This ratio is important in affecting the cooling effects of cream, the controlled release of water and the release of active agents from vehicle onto the skin. [Junginger, 1984; Junginger, 1997] The lamellar phases are phases in which surfactants molecules are arranged in the form of bilayers which separated by layers of water. The hydrocarbon chains of bilayers can present in a few types of different physical states such as liquid crystalline state (disordered state) or gel state (ordered state). However, the liquid crystalline phase could be gradually converted to a desired gel phase under suitable phase transition temperature which allows the melting of hydrocarbon chains without the loss of long-range order, as shown in Figure 5. [Eccleston, 1992; Eccleston, 1997] The presence of homologue admixtures and unsaturated or branched hydrocarbon chains could lower the transition temperature whereas the increase in the length of hydrocarbon chains would increase the transition temperature. According to a study of stabilizing agent of parenteral fat emulsion, the transition temperature of commercial soybean lecithin which possesses a long range of unsaturated C16-C18 hydrocarbon chains was lower than saturated dimyristyl lecithin, with transition temperature of -21? and 42? respectively. [Eccleston, 1992] 1.4 Emulsion Stability In practice, the stability of emulsions is generally referring to the ability of components of an emulsion including the dispersed and continuous phase to maintain their original characteristics upon manufacturing throughout a desired shelf life, without the presence of any changes in colour, viscosity, odour, texture, phase behaviour and microbial stability of emulsions on storage. The mechanisms of stabilization are different in various emulsion systems. For liquid emulsions, the stability of system was normally affected by the processes of flocculation and coalescence of dispersed particles in continuous phase which resulted from the forces-orientated aggregation of dispersed droplets and the rupture of thin film of continuous phase respectively. However, these two processes were not applicable for semi-solid emulsions as they were more structurally complex and more concentrated than liquid emulsions in which these characteristics prevented the semi-solid emulsions from being susceptible to the process of flocculation and coalescence and thus stability of the system could be maintained. [Eccleston and Florence, 1985] In contrast, the stability of semi-solid emulsions was governed by the phase behaviour of emulsifiers on storage. [Eccleston and Florence, 1985] Based on this, the presence of batch variations in the emulsifiers contributed to the instabilities of semi-solid emulsions during storage. In the case of non-ionic semi-solid creams, the formation of an additional gel phase, which is unwanted for cosmetic use and drug bioavailability, was resulted from the increased hydration of non-ionic polyoxyethylene chains of emulsifiers during storage. As a consequence, the masses of emulsifying wax vanished and the consistencies of the system increased over a period of time on storage. These caused changes in microstructure of the system which in turn rendered instabilities in the system. Besides, the batch variations in polyoxyethylene chain lengths of non-ionic surfactants and in mixed homologue compositions of fatty alcohols gave rise to the alterations of consistency and stability of the system. Hence, structural breakdown of the system would be induced after an extended period on storage. [Eccleston, 1992] The evaluation of stability of semi-solid emulsions must be done at storage temperature under a long period of time as they are liable to phase changes at high temperature condition or on heating. [Flynn, 2002] 1.5 Aims of the study In this study, the effects of pure and mixed homologue alcohols on aqueous creams prepared with non-ionic surfactant/ fatty alcohol mixed emulsifiers will be investigated by using microscopic, rheological and thermal techniques. Besides, the suitable ratio by weight of fatty alcohol to non-ionic surfactant in order to produce stable emulsions or creams will also be determined at the end of this study. Tween 60/ fatty alcohol systems were selected for this study. Thus, the overall aim of this study was to examine the detailed microstructure of the Tween 60/ fatty alcohol systems and to relate this structure to rheological properties and stability of creams. 1.6 Analytical procedures and equipment 1.6.1 Analytical Procedures The influence of pure and mixed homologue alcohols on rheological properties and stability of the standard cream prepared by non-ionic emulsifying wax, i.e. Tween 60 and fatty alcohol, will be examined. Therefore, the very first step to be taken is to prepare a standard cream, before the use of any analytical techniques. The standard cream can be formulated by varying or adjusting the concentration of non-ionic surfactant followed by the adding of fatty alcohol. Different types (pure or mixed homologues alcohols) and different concentrations of fatty alcohols will be used in order to obtain a suitable ratio by weight of fatty alcohol to non-ionic surfactant in formulation of stable cream. Following the addition of fatty alcohols, the gel network formed, as for interlamellar water layers spacing, will be influenced and thus the properties and stability of cream will be affected as well. Different analytical techniques, such as X-ray diffraction, rheometers, DSC (Differential Scanning Calorimetry), thermogravimetric technique, light and electron microscopy, creep analysis, dielectric analysis as well as NMR, had been used in many of the previous studies to examine the microstructure and properties of creams. Yet, in this study, the analysis will be mainly focusing on structure/system of emulsion, viscosity of cream (rheological properties) and transitional temperature (stability of cream). Therefore, light and electron microscopy, rheometer and thermal technique like DSC will be employed to achieve the aims of study. 1.6.2 Analytical Techniques Light and electron microscopes will be exploited to examine the structure/system of emulsion. On the other hand, the viscosity of cream will be measured by using rotational rheometer as it works effectively in analysing changes in viscosity of non-newtonian fluids. Concentric cylinders rheometer is a preferred rheometer for this study because it is relatively easy to handle and cheaper than other rheometers. [Lapasin and Pricl, 1999] Last but not least, transition temperature of cream will be determined with the use of DSC as this technique is able to detect the phase changes (from liquid phase to gel phase) based on the change of enthalpy. If compared with other techniques such as hot stage microscopy and capillary melting, DSC is more widely used and lesser amount of sample is needed in the study. [Wells, 1988; Laye, 2002] References (Introduction) Barry BW (1971). Structure and rheology of emulsions stabilised by mixed emulsifiers. Rheol. Acta 10, 96-105. Buszello K and Muller BW (2000). Emulsions as drug delivery systems. In Pharmaceutical Emulsions and Suspensions, Vol. 105, ed. Nielloud F and Marti-Mestres G, pp. 191-228. Marcel Dekker,Inc., New York. Davies JT (1957). A Quantitative Kinetic Theory of Emulsion Type. I. Physical Chemistry of the Emulsifying Agent. Proc. Intern. Congr. On Surface Activity.2nd. pp. 426-438. Butterworth, London. Eccleston GM and Florence AT (1985). Application of Emulsion Theory to Complex and Real Systems. Int. J. Cos. Sci. 7, 195-212. Eccleston GM (1992). Emulsions. In Encyclopedia of Pharmaceutical Technology, Vol. 5, ed. Swarbrick J and Boylan JC, pp. 137-188. Marcel Dekker,Inc., New York. Eccleston GM (1997). Functions of mixed emulsifiers and emulsifying waxes in dermatological lotions and creams. Colloids and Surfaces 123-124, 169-182. Eccleston GM, Behan-Martin MK, Jones GR and Towns-Andrews E (2000). Synchrotron X-ray investigations into the lamellar gel phase formed in pharmaceutical creams prepared with cetrimide and fatty alcohols. Int. J. Pharm. 203, 127-139. Eccleston GM (2007). Emulsions and Microemulsions. In Encyclopedia of Pharmaceutical Technology, Vol. 3, ed. Swarbrick J, pp. 1548-1565. Informa Healthcare, Inc., New York. Florence AT and Attwood D (2006). Physicochemical Principles of Pharmacy, 4th edn. Pharmaceutical Press, London. Flynn GL (2002). Cutaneous and Transdermal Delivery: Processes and Systems of Delivery. In Modern Pharmaceutics, Vol. 121, ed. Banker GS and Rhodes CT, pp. 187-235. Marcel Dekker,Inc., New York. Griffin WC (1949). Classification of surface-active agents by “HLB” . J. Soc. Cosmet. Chem. 1, 311-326. Junginger HE (1984). Colloidal structure of o/w creams. Pharm. Weekbl. Sci. 6, 141-149. Junginger HE (1992). Therapeutic use, Pharmacology and Pharmacy. In Dermatology, ed.Niedner R and Ziegenmeyer J, pp. 475-515. Wissenschaftliche Verlagsgesellschaft, Stuttgart. Junginger HE (1997). Multiphase Emulsions. In Surfactants in Cosmetics, Vol. 68, ed. Rieger MM and Rhein LD, pp. 155-182. Marcel Dekker,Inc., New York. Lapasin R and Pricl S (1999). Rheology of Industrial Polysaccharides: Theory and Applications. Aspen Publishers, Inc., New York. Laye PG (2002). Differential Thermal Analysis and Diffferential Scanning Calorimetry. In Principles of Thermal Analysis and Calorimetry, ed. Haines PJ, pp. 55-92. The Royal Society of Chemistry, Cambridge. Nielloud F and Marti-Mestres G (2000). Main surfactants used in the pharmaceutical field. In Pharmaceutical Emulsions and Suspensions, Vol. 105, ed. Nielloud F and Marti-Mestres G, pp. 1-18. Marcel Dekker,Inc., New York. Rosen MJ (1978). Surfactants and Interfacial Phenomena. John Wiley

Family dynamics and development of borderline personality disorder

Family dynamics and development of borderline personality disorder. Nature versus nurture is a huge debate that will likely continue for centuries to come. Nature advocates state, “just as a sunflower grows in an orderly way – unless flattened by an unfriendly environment – so does the human grow in an orderly way” (Santrock, 2010, p.22). This sentence alone completely negates the nature-nurture debate. Stating that orderly growth can be flattened by an unfriendly environment further implicates that nurture has more of an impact on development than nature does. An individual’s biological inheritance will always be his or her biological inheritance. It is the way that it is nurtured that largely influences who he or she becomes. It is my intention to provide the reader with information regarding adolescents with either symptoms or a diagnosis of Borderline Personality Disorder, apply the theoretical orientation of Erik Erikson to facilitate my beliefs regarding this subject, and present an intervention strategy that I believe would assist in this escalating problem. My hypothesis is that if the family and the adolescent with Borderline Personality Disorder learn how to establish a functional lifestyle, the adolescent will be less likely to develop the severe, life-shattering symptoms of this disorder. Literature Review Theoretical Orientation “Don’t laugh at a youth for his affectations; he is only trying on one face after another to find his own.” This quote by Logan Pearsall Smith briefly summarizes the general outcome desired in Erik Erikson’s Eight Stages of Psychosocial Development. Corey (2007) explains Erikson’s model as holistic, addressing humans inclusively as biological, social, and psychological beings. Erikson’s developmental theory describes human development over the entire life span in terms of various stages. He suggests that each stage is marked by a particular crisis that needs to be resolved (p.86). Erikson’s stages begin in infancy and go through the remainder of life. He developed eight separate stages that signify a certain level of achievement. For healthy development to occur, it is necessary to establish a clear sense of our unique selves in the context of our connection with others at each stage of life (Corey, 2007, p.86). Larsen (2008) states that each stage represents a conflict, also known as a developmental crisis which needs to be resolved. Erikson also sustained the belief that fixations, meaning if the crisis was not successfully and adaptively resolved, then personality development could become arrested and the person would continue to be preoccupied by that crisis in development (p.334). Each stage is specified by a specific age range; however, when the crisis in each stage is not successfully resolved, it makes it difficult to enter the next stage at the same age that is expected. Corey (2007) identifies the four stages before the adolescent stage: trust versus mistrust, autonomy versus shame and doubt, initiative versus guilt, and industry versus inferiority. In the first stage, trust versus mistrust, the developmental crisis is to develop a sense of trust with the child’s caregiver between the ages of birth and one. The developmental crisis in the second stage is to gain autonomy, or emotional competence, between the ages of one and three. The developmental crisis in the third stage, initiative versus guilt, is to gain initiative in social interactions between the ages of three and six. The fourth stage, industry versus inferiority, identifies the developmental crisis as gaining a sense of industry between the ages of six and 12 (p.86-88) Corey also identifies the fifth stage which is known as identity versus identity confusion and is specific to adolescents between ages 12 and 20. The developmental crisis that should be mastered is gaining an identity (p.89). If Erikson believes humans are inclusively biological, social, and psychological beings, then his theoretical orientation supports my hypothesis that if the family and the adolescent with borderline personality disorder learn how to establish a functional lifestyle, the adolescent will be less likely to develop the severe, life-shattering symptoms of this disorder. Identity Females are more prone to a borderline diagnosis than males. Kreger (2005a) states that in the general population, 75% of the individuals diagnosed with borderline personality disorder are female (Statistics about BPD section, para. 1). The important question here is why BPD is more prevalent in females than males. There are multiple theories to this phenomenon. One indicates that women are more likely to seek professional help than men. Another is that “women experience more inconsistent and invalidating messages in this society” (Kreger, “Myths and Realities about BPD, 2005b). Santrock (2010) states that “gender development is influenced by biological, social, and cognitive factors” (p.168). The biological factors are related to pubertal changes; social factors are primarily derived from social experiences; and cognitive factors result from the intermingling of the child and the social environment (p.168-173). The social cognitive theory of gender supports my hypothesis. This theory accentuates that “children’s and adolescent’s gender development is influenced by their observation and imitation of others’ gender behavior, as well as by the rewards and punishments they experience for gender-appropriate and gender-inappropriate behavior” (Santrock, 2010, p.173). Adolescents experience many, many mixed messages that are constantly thrown at them as they develop. These mixed messages have the potential to do a large amount of damage. One skill that is important to develop during adolescence is emotion regulation and behavior regulation. Santrock identifies low self-control as being an antecedent of behavioral problems. Low self-regulation has been linked with “greater aggression, teasing of others, overreaction to frustration, low cooperation, and inability to delay gratification” (p.180). These behaviors are consistent with common borderline behaviors. Teaching emotion regulation skills is a crucial component in a specific therapy that will be used in my intervention strategy. Though my intervention will not be specifically targeted for adolescent females, it appears as if a majority of the clients being served will be female. Regardless of the gender being served, emotion regulation is crucial in the success of my intervention. Moral Development Interpersonal effectiveness is another target area in my intervention. The goal is to become more interpersonally effective in relationships; however, this may be more difficult for some than others. Those with a BPD diagnosis typically have difficulty in maintaining stable relationships. This deficit can be related to dysfunction in moral development. Moral development involves two dimensions: interpersonal and intrapersonal. The intrapersonal dimension is specific to one’s individual values and sense of self whereas the interpersonal dimensions is specific to what is expected of someone in their interactions with others (Santrock, 2010, p.236). Santrock identifies Lawrence Kohlberg as developing a theory on adolescents and their perceptions of right and wrong. Kohlberg’s theory involves three levels with two stages in each level. The first level, preconventional reasoning, involves stages one and two. Stage one is identified as punishment and obedience orientation (p.238). Moral thought processes in this stage are frequently congruent with punishment. Obedience is expected because parents request it. Stage two is identified as individualism, instrumental purpose, and exchange (p.238). This stage involves pursuit of individual interests and reciprocating that freedom to others. One example would be the golden rule which involves an equal exchange. Kohlberg’s second level, conventional reasoning, involves stages three and four. Stage three is labeled mutual interpersonal expectations, relationships, and interpersonal conformity (p.238). This stage is characterized by basing moral judgments on demonstrating trust towards others, caring for others, and remaining loyal towards others. Stage four is labeled social systems morality (p.238). This stage is basing moral judgments on the comprehension of social order, law, justice and duty. Kohlberg’s third level is known as postconventional reasoning which involves stages five and six. Stage five is known as social contract or utility and individual rights. This stage involves reasoning one’s values, principles, and rights as exceeding the law. Stage six is known as universal and ethical principles. This stage involves developing a moral standard with a basis on universal human rights. Personal risk is involved in this stage and requires an individual to determine if he or she will follow the law or his or her conscience in regards to human rights (p.239). Stage two, preconventional reasoning, of Kohlberg’s theory is likely where borderline individuals adapt distorted thought patterns. The concept of pursuing one’s own interests is understandable to the borderline; however, allowing others to pursue their own interests becomes difficult. I attribute this to emotional dysregulation. Allowing others to pursue their own interests is not always difficult for the borderline. It only becomes difficult when the borderline is experiencing intense emotions and feels abandoned by the other person’s desire to pursue other interests. Stage three is also a difficult stage for borderline individuals to master. Borderlines do value the other individual’s trust, caring, and loyalty; however, their value of these characteristics is often taken to the extreme. If the other individual shows any sign of providing care towards others, the borderline can fluctuate between extreme idealizations and devaluations. Those with BPD will go to extreme measures in order to avoid being abandoned by someone important to them. Borderline individuals also struggle with interpersonal relationships. The thought of “impending separation from an important other person has a destabilizing effect on the mood, sense of self, thought patterns, and behavior”, even if this separation is imagined (GundersonFamily dynamics and development of borderline personality disorder

King Saud University Customer Satisfaction Supply Chain Management Summary

King Saud University Customer Satisfaction Supply Chain Management Summary.

In chapter 2 , the author explores the concept that the customer is always right. A concept that has become more crucial over time and particularly relevant in current times. The term is “customer centric.” It is the behavior of end customers that ultimately drives the supply chain. Chapter 2 explores the implications in terms of development of supporting logistics capabilities.The challenge here is to support products in the market place better than competition. Think about that in the context of e-commerce competitors. In the U.S. case, Amazon vs. Walmart; link marketing and logistics by means of the concept of quality of service. Please select any one of the six short case studies. Case studies are to be individually submitted. Submission should be at least two (2) pages, double spaced, 10pt. Arial or Calibri font. Charts are welcome and valued as supporting resource. Submissions will be graded based on effort, critical thinking and grammatical structure.Rubric:Why did you choose this caseRelevance to the courseBrief Summary of caseFindings and conclusions with support.
King Saud University Customer Satisfaction Supply Chain Management Summary