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DuBois’ “On the Meaning of Progress”

DuBois’ “On the Meaning of Progress”.

Greetings, students–So as promised, I’ve figured out a way to give you all a substantial bonus opportunity. We will once again, take Monday off, so there will be no class on Monday. I apologize again for my absence. This bonus opportunity gives you a chance to reflect on DuBois’ “On the Meaning of Progress”.Take Monday to write a 2-page, double spaced reflection paper on “On the Meaning of Progress”, and bring it with you to class on Wednesday for discussion. I will take them up after class is over and apply the bonus points to your total. As far as headings are concerned, do NOT waste space with the following:Your NameStudent IDPHIL 220Dr. HillsI don’t need all the “extra”–all I really need is your name and the course; that is sufficient.This bonus point opportunity will be worth 30 POINTS, basically giving you a free discussion post extra. Again, this is a bonus, so its not considered a normal discussion post–it will simply be added to your point total, should you decide to do it.I hope this is helpful!DDH
DuBois’ “On the Meaning of Progress”

Synthesis of Biologically Active Compounds | Results Chapter. One pot synthesis using 3-chloro benzaldehyde, malononitrile and 3-(dimethylamino)phenol has yielded molecule 1 with moderately good yield after purification using preparative TLC. Preliminary biological evaluations such as in vitro anti-oxidant and anti-inflammatory studies were carried out. The IC50 value for the molecule (25.2µg/mL) was found to be good when compared with ascorbic acid (IC50 = 24.8µg/mL). The dimethyl amino group and presence of chlorine seems to be favorable for in vitro biological studies. The activities demonstrated by the compound suggest that it could be useful for anti-cancer studies and give way towards the synthesis other substituted chromenes. 1. Introduction Synthesizing biologically active compounds is one of the main focuses in organic and medicinal chemistry. Among all known compounds, chromenes and its derivatives possess a unique importance. Chromenes shows wide range of biological and pharmacological properties1 such as diuretic, anticoagulant, anticancer, and antianaphylactic activity.2 Many substituted benzochromenes were proposed for the treatment of immune system diseases and diabetic complications resulted from an increase in permeability of blood vessels and a change in blood pressure.3 The current interest in 2-amino-4H-chromenes arises from their application in the treatment of human inflammatory TNFα-mediated diseases, such as rheumatoid and psoriatic arthritis and in cancer therapy.4-5 Based on the previous report on in silico target profiling, a series of molecules were identified targeting estrogen receptor (ER), TNFR and tubulin which contains chromene unit.6 This paper illustrates the synthesis and preliminary biological studies of 1. 2. Results and discussion 2.1 Chemistry The target molecule 1 was prepared using 3-(dimethylamino)phenol, 3-chlorobenzaldehyde and malonitrile as and as per the scheme 1. The reaction proceeds via Knoevenagel condensation wherein a nucleophilic addition of an active hydrogen compound takes place onto the carbonyl group which when followed by the dehydration reaction and subsequent elimination of water molecule would afford us the condensate which is often an α, β-conjugated enone. In this, the anionic compound of malononitrile added to the carbonyl carbon of the benzaldehyde leads to the formation of benzylidene malononitrile. It is a conventional method of three component one-pot synthesis. The reactants 2, 3 and 4 were dissolved in ethanol with few drops of piperidine at room temperature and heated to 75-80ºC for two hours. The progress of reaction was monitored through TLC, after the completion of the reaction the solid separated was filtered, purified by column chromatography and recrystallized using ethanol.7 As the resultant product shows more than three spots, it was then purified using a preparative TLC using ethyl acetate and hexane (7:3) as solvents. The major two spots, from preparative TLC were collected, after mass analysis it was found that one among is the expected product 1 (Fig. 2). Further, the structure of the expected product was confirmed by its IR, 1H and 13C NMR spectral analysis. 2.2 In vitro Antioxidant Studies The main feature of an antioxidant is the ability to trap free radicals. Highly reactive free radicals and oxygen species are present in biological systems. These free radicals may oxidize nucleic acids, proteins or lipids which could initiate degenerative disease. Antioxidant compounds scavenge free radicals such as peroxide, hydroperoxide or lipid peroxyl and thus inhibit the oxidative mechanisms that lead to degenerative diseases. In this study, in vitro antioxidant activity of 4-phenyl-4H-chromene derivative was assessed by nitric oxide and hydrogen peroxide free radical scavenging activity. Ascorbic acid and butylated hydroxytoluene (BHT) were used as standards. 2.2.1 Nitric oxide free radical scavenging method8 Nitric oxide is an important chemical mediator generated by endothelial cells, macrophages, neurons and involved in the regulation of various physiological processes. Excess concentration of nitric oxide is implicated in the cytotoxic effects observed in various disorders like cancer, Alzheimer’s and arthritis. The nitric oxide radical can react with superoxide to form the peroxynitrite anion, which is a potential oxidant that can decompose to produce OHË™ and NOË™. The procedure is based on the principle that, sodium nitroprusside in aqueous solution at physiological pH spontaneously generates nitric oxide which interacts with oxygen to produce nitrite ions that can be estimated using Griess reagent.9 Scavengers of nitric oxide compete with oxygen, leading to reduced production of nitrite ions. Large amounts of NOË™ may lead to tissue damage. The results of this experiment for the target molecule 1 and references were shown in table1. The experiment was done in triplicate, mean and standard deviation was calculated. From the result, IC50 value was calculated using Graph Pad Prism software (Table 1). The graphical representation of table 1 was given in fig. 3. The result from this experiment reveals that the inhibitory activity of 1 is in good comparison with ascorbic acid and butylated hydroxytoluene (BHT). The IC50 value of 1 is found to be 24.8μg/mL while for ascorbic acid is 20.6μg/mL which is in good comparison. Further, 1 shows more inhibitory activity than standard BHT (IC50 = 30.4μg/mL) 2.2.2 Hydrogen peroxide free radical scavenging method10 The hydrogen peroxide plays an important role in many biological systems and may oxidize many compounds by converting into the singlet oxygen and hydroxy radicals. Although H2O2 itself is not very reactive, but it can sometimes be toxic to cell since it may give rise to hydroxyl radical in the cells. Scavenging of H2O2 by synthesized compounds may be attributed to their radical scavenging activity, which can donate electrons to H2O2, thus neutralizing it to water. Scavenging of hydrogen peroxide by 1 may be attributed to its radical scavenging activity, which can donate electrons to H2O2, thus neutralizing it to water. The experiment was done in triplicate, mean and standard deviation was taken (Table 2). The analysis revealed that 1 exhibits significant level of antioxidant activity when compared to standard substances. The graphical representation of table 1 was given in fig. 4. The results demonstrates that the inhibitory activity of 1 is in line with ascorbic acid and better than butylated hydroxytoluene. In short, we described a convenient route towards the synthesis of 4-aryl-4H-chromene in moderately good yield. From the biological analyses, it was observed the compound possess high anti-oxidant and anti-inflammatory activity. This behaviour may be due to the presence of dimethyl amino group and electronegative chlorine. This preliminary analysis indicates that substituted 2-amino-4H-chromenes has a potency to be an anti-cancer molecule. Synthesis of various substituted 4-Aryl-4H-chromenes are under way in our laboratory. Synthesis of Biologically Active Compounds | Results Chapter

Political Science homework help

Political Science homework help. This is a paper that is focusing on the student to select the US national response to weapons of mass destruction. The paper also provides additional information to use in the writing of the assignment paper. Below is a description of the assignment:,Select the US national response to weapons of mass destruction,Instructions, First, select a newer scholarly journal article (no older than 2015) relevant to the course regarding the US national response to weapons of mass destruction (WMD) or the psychological impact of an WMD attack on the population. Then conduct an article review of that article. It must be related to the course or course materials. The intent is for students to do some external research away from the provided references and find an Article in the AMU/APUS Library. Students should search the library’s online databases, such as ProQuest, ,EbscoHost,, and others, to find scholarly or peer-reviewed articles.,Additionally, the review of the journal article is an evaluation of the article’s strengths, weaknesses, and validity. It is used to inform of the article’s value through your explanation, interpretation, and analysis. As you do this, ask the major questions that are central to the review process:,1. Firstly, what is the purpose of this article?,2. Secondly, why is it important to investigate or examine the subject of the article?,3. Thirdly, how are the authors carrying out the task? Are their methods and comments appropriate and adequate to the task?,4. Fourthly, what do they claim to have found out? Are the findings clearly stated?,5. Lastly, how does this advance knowledge in the field?,Select the US national response to weapons of mass destruction,Hint: These would make really good section titles for your paper.,Your work should consist of:,Introduction (this will have a well-defined purpose statement in your intro paragraph that provides guidance to the reader about what you are going to cover in your paper), Body (feel free to use sub-headings if necessary), Conclusion (this wraps up the key points of your work and brings your paper to a logical conclusion),Technical Requirements,Your paper must be at a minimum of 5 pages (the Title and Reference pages do not count towards the minimum limit)., A good rule of thumb is at least 2 scholarly sources per page of content., Type in Times New Roman, 12 point and double space., Students will follow the current APA Style as the sole citation and reference style used in written work submitted as part of coursework., Points will be for the use of Wikipedia or encyclopedic type sources. It is highly advised to utilize books, peer-reviewed journals, articles, archived documents, etc.,Attachments,Click Here To Download,Political Science homework help

BUS 401 Trident International Module 4 Market Selection and Foreign Entry Mode Report

term paper help BUS 401 Trident International Module 4 Market Selection and Foreign Entry Mode Report.

International Laws
Intellectual Property Rights Violations are a serious problem for U.S. companies doing business abroad. The U.S. Government’s Export Portal, export.gov, contains information on Help with Trade Problems. Research the dangers of these violations and how they adversely affect exporters. Global marketers can avoid legal conflicts by understanding the reasons conflicts arise in the first place.

Using the resources and links from the site above, discuss what can be done to protect businesses. Specifically, discuss the role of technology in protecting intellectual property rights of a business. (2 pages)
Identify and describe two legal issues that relate to global commerce.
Describe two sources of political risk. Specifically, what forms can political risk take?
(2 pages)

A draft 4-page paper with APA 
BUS 401 Trident International Module 4 Market Selection and Foreign Entry Mode Report

Company Profile For Shine Communications Business Essay

Company Profile For Shine Communications Business Essay. The assignment mainly focuses on understanding the nature of small business with the variety of business and management concepts. In this assignment target on performance evaluation of small business, applying changes to improve business performance, assess business objectives and plans , introducing new business plans. Scenario 1 Company profile for Shine Communications Among almost all the marketing communication agencies Shine Communications is ranked as one of the best small company in UK. Shine Communications was founded in 1997 as an agency for public relations and marketing communication and the company runs on four basic values: Smart, Fresh, Connected, Committed. Shine Communications awarded as the best small business / company at Sunday Times Best Small Companies To Work For 2012 and also the CEO Rachel Bell was recognized as the best leader. The company is changing day by day with the latest requirements. Shine organize many campaigns under different ways but the major way of delivering is social media activities. Team strength of the company is highly counted in scale of small business. Shine Communications is running with a team around fifty heads and they are able to work with most strong brands around the world. SWOT analysis for Shine Communications Strengths Market position Shine Communications is the most sought after personal relations agency over five years in UK. Working Partners Shine Communications has strong working capacity with strong brands across the world as BARCARDI , ebay, paramount , Intercontinental hotel group etc. it is a huge advantage for Shine Communications to have such large dealers in their business. That cause to build a magical reputation to the company name. Diversification Shine Communications is well diversified across their pattern of delivering campaigns. Shine 1 is the place where all the campaigns are built on with strategies , valuable ideas and PR related materials via marketing mix. Shine 1 also focus on delivering solutions for brand Management. Shine Studio capable enough to deliver high quality collateral design , production of videos, photography to client. Shine Live is currently engaged in for develop events , direct marketing , sampling , guerrilla marketing. Shine creations are mostly backed by social media. This way of interacting is highly demanded. When comes to Shine Social Media it based on five C’ s ; content, channel, community , carrots and connection. The diversifying factor within the business is attain higher strength to the company. Research and Development For the development and sustaining in the industry each and every business need RCompany Profile For Shine Communications Business Essay

Strategic Management Discussion Post & 4 Student Replies

Strategic Management Discussion Post & 4 Student Replies. I’m studying and need help with a Business question to help me learn.

Learning Activity #1: Individual
I need the initial post by Thursday and once i post it, I can send the student responses that I will need replies to. Please make the initial post several paragraphs and use as many sources as possible. At least 5 if you can. The replies can be like 3 paragraphs using at least one source.
This week we read of the role of board of directors in large, publicly traded corporations to ensure that the Sarbanes-Oxley Act of 2002 is implemented in a way that mitigates unethical or illegal behavior. Select one of the following industry’s listed below and identify positive and negative examples of corporate social behavior – explain how that behavior affected (positively or negatively) that industry and what can/should be done to mitigate that behavior. As always, please support and justify your answer using APA formatted references.

Airline
Banking
Healthcare
Retail
Fast Food
Oil/Gas
Wall Street (Investment/wealth management, Investment Banking)

Learning Activity #2: Individual
Irrespective of your individual/personal thoughts on climate change/global warming, do environmental sustainability initiatives exert any measurable impacts on an organization’s [your current employer or assignment #1 company] sustainable profitable growth?, why, why not? Present substantive supporting argument(s).
Sources
Strategic Management:

Chapter 10: Leading an Ethical Organization: Corporate Governance, Corporate Ethics, and Social Responsibility, Pages 314-338.

Sustainability – The Only Strategy
Global Consumerism and Sustainability
Creating Value Through Sustainable Design
The Climate Challenge: Achieving Zero Emissions

Strategic Management Discussion Post & 4 Student Replies

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