For this assignment, use the data you created in your W1 Midweek Assignment.attached Using Microsoft Excel and following the instructions given in your lecture, choose and run the appropriate descriptive statistics (graphic and numerical) to describe the sample’s age, sex, height, and year in college. Copy your output tables and graphs to a Microsoft Word document and write a brief (1-paragraph), APA-formatted report detailing your findings in the same document as the output. Model your write-up and interpretation on the example given in the lecture on Interpreting Data.
Share this: Facebook Twitter Reddit LinkedIn WhatsApp Hyper pigmented nails: Chemotherapy causing chromonychia Running head: Chemotherapy and nail toxicity Dr Kamal Kant sahu (M.D medicine,) Dr Gaurav Prakash (M.D medicine, DM medical oncology) Dr Pankaj Malhotra (MD medicine) Prof. Subhash Chandar Varma (MD medicine) Word count– 787 Figure count– 4 Table-1 References count-3 Key words: Chromonychia; leuconychia; hyperpigmeted nails; Abstract Nail toxicity are among the benign and neglected side effects linked to many chemotherapeutic drugs. Taxanes and anthracyclines are the antineoplastic drug groups most commonly implicated. Nail changes can involve several or all 20 nails and appear in temporal relationship with drug intake. Most of the time, toxicity is just a matter of concern due to cosmetic reasons, however very occasionally it may be associated with pain. True incidence of nail changes related to particular drugs are still lacking due to under-reporting and ignorance of potential side-effects among the patients, necessitating the education prior to institution of drugs and appropriate management like, avoiding potential irritants and use of topical, or oral antimicrobials, and possibly cessation or dose reduction of the offending agent or use of cryotherapy in some cases may certainly be beneficial. Introduction Chemotherapeutic drugs are associated with variety of nail changes. These nail changes are usually temporarily and use to resolve once chemo toxic drugs are stopped. Common drugs affecting are hydroxyurea, cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate and cytarabine. We here report our experience with two patients who developed nail changes during the course of chemotherapy for hematological malignancies Case Report 1 A 19-year-old young boy was admitted to the our hospital’s hematology ward with the symptoms of fever and lymphadenopathy in cervical and axillary region .Workup including bone marrow examination, PET CT scan, excisional biopsy of lymph node were done and diagnosis of T cell rich B lymphoblastic lymphoma STAGE IIIB was made .He received 1st cycle of RCHOP while hospitalized and later on discharged .He received rest of seven RCHOP courses on outdoor basis. Through examination during his outdoor follow up visits revealed transverse hyper pigmented bands on the nails (chromonychia). The bands were multiple, transverse, approximately 1-mm broad, spanning the entire nail breadth, dark grey colored, nonblanchable, nonpalpable with smooth overlying nail surface on the nail plates of all fingers and toes with well appreciation of intervening faintly grey colored bands of nails(Figure 1,2). Unluckily, he relapsed post eight cycles of RCHOP chemotherapy and henceforth started on 2nd line chemotherapy RICE (Rituximab, ifosfamide, cisplatin, etoposide), 1st course of which was given to him uneventfully recently till the time of writing this report. Case Report 2 A 55-year- old female presented to hematology clinic with complaints of pain abdomen for 6 months with history of significant loss of weight and appetite. Per abdomen examination revealed presence of abdominal lump with dimensions of 18 cm x 15 cm with no hepatosplenomegaly.Tru-cut biopsy of lump was done .Histopathological examination and immunohistochemistry confirmed high grade, B cell type non-Hodgkin’s lymphoma. She was further investigated and found to have stage IVB disease .Due to financial issues she was given CVP regimen (cyclophosphamide,doxorubicin,vincristine),however she relapsed following 3 courses by the time of writing this report. During her outdoor visits, she was found to have diffuse, black pigmentation with longitudinal striae in the nails of digits of both hands (figure 3, 4) and feet. Discussion Amongst the innumerable side effects that chemotherapeutic drugs have, mucocutaneous one are the most worrisome for the patients probably due to cosmetic reasons. Different patterns of nail discoloration like chromonychia, leukonychia (including Mee’s and Muehrcke’s lines), Beau’s lines, paronychia and onycholysis have been well documented(1). Drugs commonly implicated are – vincristine, hydroxyurea, etoposide, daunorubicin, bleomycin, cyclophosphamide, dacarbazine, 5-fluorouracil and methotrexate (1, 2). The most frequent variety of chromonychia is melanonychia which is best defined as a dark pigmentation of nails observed as diffuse, transverse, or longitudinal band patterns(2).Some more common and important nail toxities have been summarized in table 1 with their description of morphology and pathophysiology of origin. Effect of cyclophosphamide on nails ranges from diffuse, black pigmentation to dark longitudinal striae , and diffuse, dark gray pigmentation located proximally, with overlying transverse, black bands(2). Doxorubicin produces commonly transverse, dark brown bands alternating with white stripes and dark brown diffuse pigmentation bands 4–5 mm wide, which affect two-thirds of the distal portion of the nail(3). Hydroxyurea produces pigmentation that has a diffuse, dark brown color which may appear as single or double transverse bands. Our patient received all of the above mentioned drugs during his due course of illness Table1. Definitions of some common nail toxities and probable pathophysiology of origin (1, 2) Name Description Pathophysiology of origin 1) Melanonychia Dark pigmentation of nails observed as diffuse transverse or longitudinal band patterns Melanin deposition 2) Mee’s lines (true transverse Leukonychia) Single, transverse, nonblanchable bands Toxic damage to the nail matrix resulting in abnormal keratinization causing altered light diffraction in retained parakeratotic onychocytes 3) Muehrcke’s lines (apparent leukonychia) Multiple, white, transverse pale bands separated by strips of pink nail bed which fade on digital compression Due to edema in nail bed or alteration of nail plate attachment to the nail bed due to the vascular abnormalities resulting due to chemotherapy 4) Beau’s lines Horizontal (transverse) depressions in the nail plate that run parallel to the shape of the white, moon-shaped portion of the nail bed (lunula) seen at the nail’s origin Caused by trauma or local disease involving the nail fold leading to sudden interruption of nail keratin synthesis and grow distally with the nail plate. Conclusion Nail changes although seems to be common following chemotherapy, however goes unnoticed and underlooked in the lights of more important burning issues of chemotherapy both by physician and patient and hence true incidence of nail related changes is much more than reported especially in dark colored individuals like our patient and hence requires keen observation during follow up of these patients. References 1.Hinds G, Thomas VD. Malignancy and cancer treatment-related hair and nail changes. Dermatologic clinics. 2008;26(1):59-68, viii.. 2.Dasanu CA, Vaillant JG, Alexandrescu DT. Distinct patterns of chromonychia, Beau’s lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma. Dermatology online journal. 2006;12(6):10. 3.Gilbar P, Hain A, Peereboom VM. Nail toxicity induced by cancer chemotherapy. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners. 2009;15(3):143-55. LEGEND OF FIGURES Figure1.Multiple hyper pigmented, transverse bands, approximately 1-mm broad, spanning the entire nail breadth, dark grey colored, nonblanchable, nonpalpable with smooth overlying nail surface on the nail plates of all fingers and toes with well appreciation of intervening faintly grey colored bands of nails. Figure2.Close up image of bilateral nails with clear depiction of hyper pigmented bands. Figure3. Multiple hyper pigmented, longitudinal striae noted in bilateral nails of fingers. Figure4. Hyper pigmented longitudinal bands predominant in distal aspect of nails Share this: Facebook Twitter Reddit LinkedIn WhatsApp
Word Document Formatting.
This task can be done by any writer so long as you have skills in word processing… It isnt much of a task since there is no thinking or research involved.So all i need the margins are really poorly formatted. please indent them properly and set the Titles and subtitles properly.For images, flowcharts and graphs, make sure you insert captions properly so they will be read in the List of Figures, Charts and Tables where appropriate. I will be very keen on indentation, margins, formatting and alignment. Honestly this document is not neat and i really hope if you commit to working on it you will deliver neat work. Dont forget to add table of content, list of graphics for the graphs, charts for the flowcharts and tables for the tables.
Word Document Formatting
Write down mathematical formulae.
In this question write down a simple, formal, mathematical model. We wish to analyze the consumer’s choice of housing. In particular, we want to compare the impact on utility of a change in the price of housing for a renter and a homeowner. You may assume that all individuals consume two things – housing (H), and a second consumption good (C).1. (10 points) Write down the renter’s problem. Write down the homeowner’s problem.2. (10 points) What happens to the renter’s utility when pH , the price of housing, changes? The homeowner’s utility? What happens to the renter’s optimal consump-tion of H and C? The homeowner’s consumption?3. (10 points) Some economists believe that, during the last economic crisis, the government should take action to boost housing prices. Analyze the effects of such a policy in light of your model.
Write down mathematical formulae
Statistics homework help
Statistics homework help. This is a paper that is focusing on the student to choose a community that is from a designate location. The paper also provides additional information to use in writing this assignment paper well.,Choose a community that is from a designate location,Your community should be within a specifically designated geographic location.,One must clearly delineate the following dimensions before starting the process of community assessment:,Describe the population that is being assessed?,What is/are the race(s) of this population within the community?,Are there boundaries of this group? If so, what are they?,Does this community exist within a certain city or county?,Are there general characteristics that separate this group from others?,Education levels, birth/death rates, age of deaths, insured/uninsured?,Where is this group located geographically…? Urban/rural?,Why is a community assessment being performed? What purpose will it serve?,How will information for the community assessment be collected?,Assessment,After the community has been defined, the next phase is assessment. The following items describe several resources and methods to gather and generate data. These items serve as a starting point for data collection.,The time frame for completion of the assessment may influence which methods. Nonetheless, these items should be reviewed to determine what information will be useful to collect about the community that is being assessed. It is not necessary to use all of these resources and methods; however, use of a variety of methods is helpful when one is exploring the needs of a community.,Data Gathering (collecting information that already exists),Demographics of the Community,When demographic data are collect, it is useful to collect data from a variety of levels so comparisons can be made., If the population that is being assess is located within a specific setting, it may be best to contact that agency to retrieve specific information about that population., The following resources provide a broad overview of the ,demographics, of a city, county, or state:, State and County Quick Facts—Easy access to facts about population, housing, economics, geographic data, business, based on U.S. Census data, Obtain information about a specific city or county on these useful websites www.epodunk.com and www.city-data.com,Attachments,Click Here To Download,Statistics homework help
GBA 334 Saint Leo University Business Writing Question
write my term paper GBA 334 Saint Leo University Business Writing Question.
I’m working on a business writing question and need a sample draft to help me understand better.
Part 1Give an example from your own experience where you used a break-even point analysis?(If you are not in receipt of your textbook when this is due, use the course slides and/or the internet to publish your discussion.)Part 2How does human capital provide a basis for competitive advantage? What are the five characteristics of high-involvement management, and what evidence exists to support the effectiveness of this approach?Include references such as your textbook, journals, trade articles, etc., to support your response. Properly cite any references using APA format.Part 3One of the challenges facing managers is the fact that organizations are no longer constrained by national borders. Go to the SHRM homepage (www.shrm.org) and identify OB topics that relate to globalization. Find and list at least three OB topics
GBA 334 Saint Leo University Business Writing Question
Easy PowerPoint/Auditioning for Reality TV assignment, communications homework help
Easy PowerPoint/Auditioning for Reality TV assignment, communications homework help.
PLEASE READ CAREFULLY BECAUSE THE LAST TUTOR I CHOSE SCREWED ME OVER.I need three pictures of tangible objects (like show and tell) and need to know why they are important to me and why I should be selected for this reality TV show.REALITY SHOW I AM CHOOSING (unless you have a better idea)= Startup UFor this presentation, pretend you are auditioning for a reality TV show (it can be a real or fictitious show). You must use three personal items to effectively describe who you are and why you should be selected for the show – imagine it’s like a Show & Tell speech from elementary school. You are to tell the audience why you chose the items and why you should be picked for the show. 1. Introduction (tell us your name, preview your objects, grab the audience’s attention) 2. Body (further discuss your three objects and why they are important, connect each with transitions) 3. Conclusion (make a last impression, restate why you should be selected for the show)Thisis for my public speaking class. The PowerPoint does not have to be long. I just can’t think of three objects to use and what to say. This “speech” is only 1-2 minutes, so it doesn’t have to be long. I mostly just need the three objects and why they are important and why I should be chosen for the reality show.
Easy PowerPoint/Auditioning for Reality TV assignment, communications homework help
reasearch paper(middle eastern)
reasearch paper(middle eastern).
Media Project1.docxmust meet all requirement. no plagiarism. this is 10-11 pages long reasearch papers using 2 different middle eastern newspapers. must be done in 16 hours.please don’t just jump into work without reading descriptions and requirement first.i will report all scammers who just say they can do it and going back on their words later and waste my time. i am sick of ppls who say they can do it and then later telling me double the payment and provide me crappy work. i will withdraw my pledge and report them without exception.
reasearch paper(middle eastern)