OverviewOverview Imagine you are the manager of a software development team working on new applications for your company, Optimum Way Development, Inc. Your company has just announced a new employee program where a select number of employees will be given paid time to perform research in an area of interest in their field. In order to apply, you must create a presentation that will be reviewed by a panel of executives in the company. These executives are business professionals who do not have technical education or experience.PromptConsider your own field of study (degree program) and what questions or issues you find interesting within this field. If you have trouble thinking of some, you can search the internet to see what professionals in the field believe are the most pressing questions or issues in the field today.To complete this activity, address the following criteria:
Create a presentation that explains what your area of interest is. In your presentation, do the following:
Pose your specific research question on one specific, current issue in your field of study.
Use communication techniques that are appropriate for the audience’s preferences and motivations.
Articulate who the research will help. Include supporting details that explain the need for the research and the audience for the research.
Create the speaker’s notes that would accompany each slide of the presentation. In the notes, use dialogue that communicates the appropriate main ideas to the audience.
Resources are not required, but any resources used must be appropriately cited using APA style. The following resources may help support your work on the project:
Shapiro Library Resource: APA Style: Basics
Resource: Add Speaker Notes to Your Slides
Guidelines for SubmissionTo complete this activity, you must submit a research presentation.Your research presentation must:
Be at least 500 words (includes both the slide content and the corresponding speech)
Be submitted in a presentation format (e.g., PowerPoint)
Completely address all of the requirements in the Prompt section
Include the speech that would accompany the presentation, either in the notes section of each slide or in an additional document
SUNY Old Westbury Cyber Security at Optimum Way Development Inc Presentation
Watch the following videoAfter reviewing the article, compose a case analysis.IntroductionIdentify two to five key problemsWhy do they exist?Who is responsible for them?BackgroundSet the scene: Background information, relevant facts, and most important issues.EvaluationUncover possible solutes/changes neededOutline the key facts on which you are focusingState why or why not these parts are not working wellPropose Solutions/ChangesProvide specific and realist solutionsExplain chosen solutionSupport solution with solid evidence. Concepts from class (text, readings, discussions, lectures), outside research, or personal experience.Paper RequirementsFollow current APA format. The paper should be at least three pages in length
UOM Fashion Free Culture Increased Sales and Innovation Case Study
make two Multiple choice questions， one short essay question, one Calculation problem （also give right answers, For multiple choices, explain the reason why you think it is important for students to distinguish the correct answer from incorrect ones.The topics are about Bond Market, Mortgage Markets, Foreign Exchange Markets, Credit Risk Management, Interest Rate RiskYou cannot have two similar questions/computational problems. If that happens, the second one does not count.You can build your questions from regular lecture slides, out of class activity sheets, math problem assignments, end-of-chapter questions and projects. But you CANNOT simply copy from these materials, which will render a zero score. A 90% similarity is also undesirable.Providing incorrect solutions will lower your score.Copying from textbook but not covered in lecture slides will cause troubles, and so that will lower your score.Questions too straightforward get lower score.
UNH Bond Market Worksheet
Polymeric Nanoparticles in Drug Delivery
Share this: Facebook Twitter Reddit LinkedIn WhatsApp Abstract For the past few decades, there has been a respectable exploration interest in the territory of drug conveyance utilizing particulate conveyance frameworks as transporters for little and huge particles. Particulate frameworks like nanoparticles have been utilized as a physical methodology to adjust and enhance the pharmacokinetic and pharmacodynamic properties of different sorts of drug particles. They have been utilized within vivo to secure the drug element in the systemic course, confine access of the medication to the picked destinations and to convey the drug at a regulated and managed rate to the site of activity. Different polymers have been utilized within the detailing of nanoparticles for drug conveyance exploration to expand helpful profit, while minimizing side impacts. Here, we survey different parts of nanoparticle plan, characterization, impact of their attributes and their requisitions in conveyance of medication atoms and restorative genes. Introduction for reflective statement The utilization of nanotechnology in medicine and all the more particularly drug conveyance is situated to spread quickly. At present numerous substances are under examination for drug conveyance and all the more particularly for growth help. Interestingly pharmaceutical sciences are utilizing nanoparticles to diminish lethality and symptoms of medications and up to as of late finished not understand that transport system themselves may force dangers to the patient. The sort of perils that are presented by utilizing nanoparticles for medication conveyance are past that postured by traditional dangers forced by chemicals in established conveyance frameworks. For nanoparticles the information on molecule danger as got in inward breath lethality demonstrates to the way industry standards to explore the potential perils of nanoparticles. The toxicology of particulate matter varies from toxicology of substances as the forming chemical(s) could conceivably be dissolvable in living lattices, therefore impacting incredibly the potential introduction of different inward organs. Then again, retained species might likewise impact the potential lethality of the breathed in particles. Discussion For nanoparticles the circumstances is distinctive as their size opens the potential for intersection the different living hindrances inside the constitution. From a positive perspective, particularly the possibility to cross the blood mind hindrance may open new routes for medication conveyance into the cerebrum. What’s more, the nanosize likewise takes into consideration access into the cell and different cell compartments including the core. An incalculable number of substances are at present under examination for the arrangement of nanoparticles for drug conveyance, fluctuating from organic substances like egg whites, gelatin and phospholipids for liposome’s, and moresubstances of a chemical nature like different polymers and strong metal holding nanoparticles. It is evident that the potential collaboration with tissues and cells, and the potential harmfulness, incredibly relies on upon the genuine arrangement of the nanoparticle definition. This paper gives a review on a portion of the as of now utilized frameworks for medication conveyance. In addition the potential useful utilize additionally consideration is attracted to the inquiries how we ought to continue with the security assessment of the nanoparticle plans for medication conveyance. For such testing the lessons gained from molecule lethality as connected in particle toxicology may be useful. In spite of the fact that for pharmaceutical utilize the current prerequisites appear to be satisfactory to identify a large portion of the antagonistic impacts of nanoparticle definitions, it cannot be normal that all parts of nanoparticle toxicology will be distinguished. Thus, likely extra more particular testing might be required. Later years have seen exceptional development of exploration and provisions in the territory of nanoscience and nanotechnology. There is expanding confidence that nanotechnology, as connected to drug, will acquire critical developments the determination and medicine of malady. Designed nanoparticles are a critical device to understand various these provisions. It must be distinguished that not all particles utilized for therapeutic purposes go along to the as of late proposed and now by and large acknowledged meaning of a size ≤100 nm.however, numerous tests must be overcome if the provision of nanotechnology is to understand the expected enhanced comprehension of the patho-physiological premise of illness, carry more refined analytic chances, and yield enhanced thereapies. Toxicological dangers of nanoparticles To utilize the potential of Nanotechnology within Nanomedicine, full consideration is required to security and toxicological issues. For pharmaceuticals particular medication conveyance details may be utilized to build the alleged helpful proportion or record being the edge between the measurement required for clinical viability and the dosage prompting side effects ( (lethality). Notwithstanding, additionally for these particular details a toxicological assessment is required. This is especially valid for the provisions of nanoparticles for drug conveyance. Medicinal necessity For medicinal purpose certain routine measures requirement to be performed which will hang on to various potential dangers. In any case, it might be expected that not all dangers are at this minute known for the utilization of nanoparticles. Advantages Nanoparticle-based drug conveyance frameworks have extensive potential for medication of tuberculosis (TB). The essential mechanical favorable circumstances of nanoparticles utilized as medication bearers are high stability, high transport limit, achievability of fuse of both hydrophilic and hydrophobic substances, and possibility of variable courses of organization, including oral provision and inhalation. Nanoparticles can likewise be intended to permit regulated (supported) drug discharge from the network. These properties of nanoparticles empower change of drug bioavailability and decrease of the dosing recurrence, and may resolve the issue of nonadherence to endorsed help, which is one of the significant deterrents in the control of TB scourges. The accompanying are around the essential innovative points of interest of nanoparticles as medication transporters: high security (i.e., long timeframe of realistic usability); high bearer limit (i.e., numerous pill particles could be consolidated in the molecule grid); attainability of fuse of both hydrophilic and hydrophobic substances; and practicality of variable courses of organization, including oral organization and inward breath. These bearers can likewise be intended to empower regulated (supported) pill discharge from the matrix.the conduct of polymeric nanoparticles in the gastrointestinal tract is affected by their bioadhesive properties; grip of nanoparticles to the mucosa upgrades the retention of the copartnered medication, hence expanding its bioavailability. Consequently, lectins have been indicated to enhance mucoadhesion of the pill because of the biorecognition of the lectin-united transporters by glycosylated structures in the intestine.their significant focal points, for example, change of medication bioavailability and lessening of the dosing recurrence, may make a sound support for better administration of the malady, making specifically watched medicine more pragmatic and moderate. An alternate significant focal point of the nanoparticles is the plausibility of the adaptable courses of pill organization, including oral and inward breath courses. Furthermore, high soundness of the nanoparticles proposes long time span of usability. It could be normal that future examination will focus on the improvement of the vectorized conveyance frameworks consolidating preferences of the colloidal bearers, for example, expansive payloads of a medication, with animated focusing to the spoiling destinations. Conclusion The achievement of this innovation will likely rely on upon toxicological issues connected with comprehension of the destiny of nanocarriers and their polymeric constituents in the physique, and end of the danger of the remaining natural solvents. In this admiration, the likelihood of utilizing pill bearers produced out of characteristic polymers (e.g., chitosan or alginate) speaks to a magnetic point of view. The utilization of Nanotechnology in solution and all the more particularly pill conveyance is situated to spread quickly. For a long time pharmaceutical sciences have been utilizing nanoparticles to lessen danger and symptoms of medications. Up to as of late it was not understood that these transporter frameworks themselves may force dangers to the patient. The sort of risks that are presented by utilizing nanoparticles for pill conveyance are past that postured by expected dangers forced by chemicals in conveyance networks. In any case, in this way, the experimental ideal model for the conceivable (unfavorable) reactivity of nanoparticles needs and we have small comprehension of the nuts and bolts of the cooperation of nanoparticles with living cells, organs and life forms. A theoretical comprehension of natural reactions to nanomaterials is required to create and apply sheltered nanomaterials in medication conveyance later on. Moreover a nearby coordinated effort between those working in pill conveyance and molecule toxicology is vital for the trade of ideas, strategies and skill to accelerate this issue. References Gelperina.S. et al. (2005). The Potential Advantages of Nanoparticle Drug Delivery Systems in Chemotherapy of Tuberculosis.American journal of Respiratory and critical care medicine. 172(12).1487-1490). Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718451/ Albrecht C, Knaapen AM, Becker, et al. The crucial role of particle surface reactivity in respirable quartz induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung.Respir Res.2005;6:129. Åkerman ME, Chan WCW, Laakkonen P, et al. Nonocrystal targeting in vivo.PNAS.2002;99:12617–21. American Journal of Respiratory and Critical Care Medicine Alyautdin RN, Petrov VE, Langer K, et al. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles.J Pharm Res.1997;14:325–8.erican Journal of Respiratory and Critical C Bourges JL, Gautier SE, Delie F, et al. Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles.Invest Ophthalmol Vis Sci.2003;44:3562–9 Medicine Borm PJ, Kreyling W. Toxicological hazards of inhaled nanoparticles – potential implications for drug delivery.J Nanosc Nanotechnol.2004;4:521–31. Borm PJ, Muller-Schulte D. Nanoparticles in drug delivery and environmental exposure: same size, same risks?Nanomedicine.2006;1:235–49. Benardi RJ, Lowery AR, Thompson PA, et al. Immunoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines.J Neurooncol.2007 Sep 6;Epub ahead of print. Borm PJ. Particle toxicology: from coal mining to nanotechnology.Inhal Toxicol.2002;14:311–24. Cascone MG, Lazzeri L, Carmignani C, et al. Gelatin nanoparticles produced by a simple W/O emulsion as delivery system for methotrexate.J Mat Sc: Mat in Med.2002;13:523–6. Chen LC, Nadziejko C. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice V CAPs exacerbate aortic plaque development in hyperlipidemic mice.Inhal Toxicol.2005;17:217–24. Campen MJ, McDonald JD, Gigliotti AP, et al. Cardiovascular effects of inhaled diesel exhaust in spontaneously hypertensive rats.Cardiovasc Toxicol.2003;3:353–61. Calderon-Garciduenas L, Reed W, Maronpot RR, et al. Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution.Toxicol Pathol.2004;32:650–8. Damascelli B, Patelli GL, Lanocita R, et al. A novel intraarterial chemotherapy using paclitaxel in albumin nanoparticles to treat advanced squamous cell carcinoma of the tongue: preliminary findings.Am J Roentgenol.2003;181:253–603. Donaldson K, Stone V, Tran CL, et al. Nanotoxicology.Occup Environ Med.2004;61:727–28. Duncan R. The dawning era of polymer therapeutics.Nat Rev Drug Disc.2003;2:347–60. Edetsberger M, Gaubitzer E, Valic E, et al. Detection of nanometer-sized particles in living cells using modern fluorescence fluctuation methods.Biochem Biophys Res Commun.2005;332:109–16. Elder A, Gelein R, Silva V, et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system.Environ Health Perspect.2006;114:1172–8. Ferrari M. Cancer nanotechnology: opportunities and challenges.Nat Rev Cancer.2005;5:161–71. Gibaud S, Demoy M, Andreux JP, et al. Cells involved in the capture of nanoparticles in hematopoietic organs.J Pharm Sci.1996;85:944–50. Gomes AJ, Lunardi LO, Marchetti JM, et al. Indocyanine green nanoparticles useful for photomedicine.Photomed Laser Surg.2006;24:514–21. Gupta AK, Curtis ASG. Surface modified supermagnetic nanoparticles for drug delivery: interaction studies with human firbroblasts in culture.J Mater Sci: Mat in Med.2004;15:493–6. Hoshino A, Fujioka K, Oku T, et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification.Nano Lett.2004;4:2163–9. Huang M, Khor E, Lim L-Y. Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation.Pharm Res.2004;21:344–53. JECFA (Joint FAO/WHO Expert Committee on Food additives) Summary of Evaluations Performed by the Joint FAO/WHO Expert Committee on Food Additives.INS 175.2001. Kawano T, Yamagata M, Takahishi H, et al. Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses.J Control Release.2006;111:382–9. Kirchner C, Liedl T, Kudera S, et al. Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.Nano Letters.2005;5:331–8. Koziara JM, Lockman PR, Allen DD, et al. Paclitaxel nanoparticles for the potential treatment of brain tumors.J Control Release.2004;99:259–69. Kreuter J. Nanoparticulate systems for brain delivery of drugs.Adv Drug Deliv Rev.2001;47:65–81. Lenaerts V, Nagelkerke JF, Van Berkel TJ, et al. In vivo uptake of polyisobutyl cyanoacrylate nanoparticles by rat liver Kupffer, endothelial, and parenchymal cells.J Pharm Sci.1984;73:980–2. Lockman PR, Koziara JM, Mumper RJ, et al. Nanoparticle surface charges alter blood-brain barrier integrity and permeability.J Drug Target.2004;12:635–41. Panyam J, Zhou WZ, Prabha S, et al. Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery.FASEB J.2002;16:1217–26. Oberdörster G, Sharp Z, Atudorei V, et al. Translocation of inhaled ultrafine particles to the brain.Inhalation Toxicol.2004;16:437–45. Share this: Facebook Twitter Reddit LinkedIn WhatsApp
Health Research Literature Research Paper
assignment helper Health Research Literature Research Paper. Evaluation of Frankenstein Frankenstein written by Mary Shelley is an exemplary written piece in English literature. The novel is influenced by many movements that were prominent in the period of romanticism. This paper evaluates the important motifs of the novel with its cultural roots to the concept of prejudice, character sketch of victor Frankenstein and Justine Moritz with respect to their character usage to deliver the thematic concern of the author. Moreover the paper also describes the concept of education and upbringing of child through the analysis of charter of Frankenstein in the novel. Character Sketch of Victor Frankenstein Victor Frankenstein is the major character and the most important narrator of the story. His portrayal in the novel is more of a person who had always deserted himself in loneliness which could be considered as a dangerous element of his personality. In the beginning his interest was in poetry but after some time science became his obsession. He wanted to discover the secrets of heaven and earth. He studies the outlawed sciences and become interested about the secret of life. He studies the secrets of giving birth to an inhuman creature. After researching and all of his experiments he forms a monster to life that kills his brother, best friends, wife and everyone close to Frankenstein just because he refuses to create a mate for the monster (Shelley, Panshin,Health Research Literature Research Paper
econ 201, math problem
econ 201, math problem. Help me study for my Economics class. I’m stuck and don’t understand.
1. Two women appear before King Solomon at his palace, along with an infant. Each woman claims that the infant is her child. The child is “worth” 100 dinars to his true mother, but he is only “worth” 50 dinars to the impostor. The king knows that one of the two women is the true mother of the child, and he knows the “values” that the true mother and the impostor ascribe to the child, but he does not know which woman is the true mother, and which the impostor. To determine which of the two women is the true mother, the kind explains to both women that he will implement the following steps:
(a)He will ask the first woman whether the child is hers. If she
answers negatively, the child will be given to the second woman.
If she answers affirmatively, the king will continue to the next
(b)He will ask the second woman if the child is hers. If she answers
negatively, the child will be given to the first woman. If she
answers affirmatively, the second woman will pay the king 75
dinars, and receive the child, and first woman will pay the king
i. Assume that each woman has a payoff of
0 dinar if she does not
receive the child. Draw the game tree when (a) The first woman
is the true mother and when (b) The second woman is the true
ii. Find and report the subgame perfect equilibrium under (a) and
(b), and describe what happens (who gets the child and how
much is paid by each woman) in each equilibrium.
2. From the movie A Beautiful Mind :
there are 4 men and 5 women at the bar. There are two types of women γ and ψ . Out of 5 women one is type γ and 4 are
type ψ. Each man decides awoman (γ or ψ) to hit on, simultaneously. Suppose the ψ’s are equally attractive to the men, with appeal b. The γ is more attractive, with appeal a > b. If more than one man attempts to hit on the γ, they succeed neither with the γ(they block each other), nor with any ψ(the latter feel slighted). Any man choosing not to hit on the γ succeeds with a ψ, for a payoff of b. If a man is the only one who hits on the γ, he succeeds, with a payoff of a. Find all Nash equilibria of this game(both pure and mixed).
3. Suppose there are n firms in the Cournot oligopoly model Let q i denote the quantity produced by firm i, and let Q =q1+…+qn denote the aggregate quantity on the market. Let P denote the market- clearing price and assume that inverse demand is given by P(Q) =γ−Q(assumingQ<γ, elseP=0). Assume that the total cost offirmifrom producing quantityqiisCi(qi) =αq2i+βqi. That is, there are no fixed costs and β<γ.
(a)Following Cournot, suppose that the firms choose their quantitiessimultaneously. What is the Nash equilibrium? What happens asn approaches infinity?
(b)Now assumen=2. Further, assume that the total cost of firm1 isC1(q1) =αq21+βq1and firm 2 isC2(q2) =cq2. Followingthe Cournot model, what is the Nash equilibrium? Under whatconditionq∗1>0?
econ 201, math problem
Aspen University Play and Learning Preschool Child Audio Presentation
Aspen University Play and Learning Preschool Child Audio Presentation.
Remember to submit your work following the file naming convention FirstInitial.LastName_M01.docx. For example, J.Smith_M01.docx. Remember that it is not necessary to manually type in the file extension; it will automatically append.Start by reading and following these instructions:1. Quickly skim the questions or assignment below and the assignment rubric to help you focus.2. Read the required chapter(s) of the textbook and any additional recommended resources. Some answers may require you to do additional research on the Internet or in other reference sources. Choose your sources carefully.3. Consider the discussion and the any insights you gained from it.4. Create your Assignment submission and be sure to cite your sources, use APA style as required, check your spelling.Assignment: Create a 5-7 minute You Tube video of you discussing recommended technology uses for children from infancy to third grade. Choose at least one site that will enhance the developmental growth for each age group. Copy and paste the links to a word document and put in the drop box along with your video
Aspen University Play and Learning Preschool Child Audio Presentation
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