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Answer (2) 200-300 responses

Answer (2) 200-300 responses.

ANSWER QUESTION 1 and 2 with instructions beneathQUESTION #1 (200-300 words max)Please address the following questions after viewing the entire video:
“America: Still Racist” A video essay by Contrapoints (Natalie Wynn).

Contrapoints is a transgender woman who dropped out of a Philosophy PhD program to become a popular Youtuber (she “transitioned” after she already had made several videos on her channel). Though she tends to use some raunchy dark humor, I find her videos to be loaded with sociological and philosophical insights, in a format that can appeal to many millennials.
Whose job is it to mend the crimes of history? Do we have to take responsibility for crimes that happened over a hundred years ago? If so, how? How exactly does this video serve as a response to any of the 4 Frames of what Eduardo Bonilla-Silva calls “Color-Blind Racism”?
QUESTION #2 (200-300 words max)

In Chapter 8 of The Stickup Kids by Randol Contreras, Contreras analyzes how drug robbery torture and other forms of emasculation reinforce society’s gender roles. Please refer to Essentials of Sociology: Chapter 9 in order to make sense of these situations in The Stickup Kids. For example, you can illustrate one or two specific concepts like patriarchy, misogyny, hegemonic masculinity, toxic masculinity, or intersectionality. You can also reference any specific form of feminist theory, if you believe it applies to the story. Be thoughtful!

Answer (2) 200-300 responses

An Essay On The Treatment Of Diabetes

Share this: Facebook Twitter Reddit LinkedIn WhatsApp Diabetes is an increasingly common metabolic disorder distinguished by lack of production or dysfunction of the insulin hormone, resulting in raised blood glucose levels, known as hyperglycaemia (Bailey 2015). In 2015, it was recorded that approximately 415 million individuals had diabetes worldwide, which is expected to increase to 642 million individuals by 2040 (International Diabetes Federation (IDF) 2015). Financially, it was estimated that the total cost for both the direct and indirect care associated with diabetes within the UK is currently £23.7 billion. This is expected to rise to £39.8 billion by the year 2035-2036 (Diabetes UK 2016). There are two main forms of diabetes mellitus, Type 1 (Insulin-Dependent) and Type 2 (Non-Insulin Dependent). Type 1 is a chronic autoimmune disease which develops following the destruction of the β-cells within the islets of Langerhans throughout the pancreas. The β-cells function by synthesising and secreting insulin in the response to the maintenance of glucose levels. (Bluestone et al 2010) (Kulkarni 2003). When these cells are destroyed, this results in the loss of blood glucose control. Therefore, insulin replacement is the main treatment therapy in order to maintain optimum blood glucose levels (Bacha and Klinepeter 2015) (Bailey 2015). Type 2 (Non-Insulin Dependent) diabetes is the most common type, affecting approximately 85-90% of individuals with diabetes (Hex et al 2012). This type occurs when the β-cells produce defective insulin or when insulin secretion is reduced resulting in insulin resistance and hyperglycaemia (Nyenwe et al 2011). Certain therapeutic treatments can be given to maintain blood glucose levels (Bailey 2015). At present there is no single drug available that can treat all aspects of diabetes mellitus, due to the complexity of the β-cells within the pancreas. However, there are various medications currently available that can be used in combination with lifestyle changes to reduce hyperglycaemia and maintain blood glucose homeostasis (Bailey 2015) (Breuer et al 2010). Treatment therapy is selected according to the pathophysiology of the individual. More recent approved treatments include SGLT-2 inhibitors, bile acid sequestrants and incretin mimetics (Bailey 2015). More focus being brought to peptide treatment therapy relating to neurotensin (Chowdhury et al 2013). 2.0 Type 2 Diabetes (Non-Insulin Dependent) The maintenance of blood glucose homeostasis is performed by two hormones secreted from the islet of Langerhans cells in the pancreas. Insulin, secreted from the β-cells and glucagon, secreted from the α-cells (Meece 2007). Type 2 Diabetes Mellitus develops when the β-cells within the pancreas become dysfunctional and the volume of insulin released is inadequate to maintain glycaemic control (Kasuga 2006) (Nyenwe et al 2011). Hyperglycaemia ensues, increasing the demand for insulin, and to compensate the β-cells excessively release insulin to lower the blood glucose level and over time these cells lose their function (Kasuga 2006). 3.0 Current treatments The occurrence of Type 2 diabetes continues to increase globally; and whilst the pathophysiology and further complex issues are understood, treatment therapy can be difficult (Nyenwe 2011). Currently approved diabetic drug therapies are listed in Table 1. Table 1. Current approved drug therapy used in the treatment of Type 2 diabetes to aid in the maintenance of blood glucose homeostasis. DRUG ROUTE MECHANISM OF ACTION IMPLICATIONS BIGUANIDE Metformin Oral Suppresses hepatic glucose production and increase insulin sensitivity within the muscle tissue Linked to lactic acidosis. Gastrointestinal side effects. Should be avoided in deteriorating renal function or liver impairment. SULFONYLUREAS Gliclazide Glimepiride Tolbutamide Oral Increases insulin secretion by binding to sulfonylurea receptor-1 on β-cells resulting in depolarisation and calcium influx Weight gain is possible. High risk of hypoglycaemia – need for close blood glucose monitoring. DPP-4 INHIBITORS Saxagliptin Sitagliptin Vildagliptin Oral Inhibits enzyme DPP-4, prolonging incretin hormones (GLP-1 and GIP) half-lives Association with pancreatitis SGLT2 INHIBITORS Dapaglifozin Oral Inhibit Sodium-Glucose-Co-transporter-2 proteins to increase glucose elimination in urine High risk of developing genital and urinary tract infections. High risk to hypoglycaemia. GLP-1 MIMETICS Subcutaneous injection Binds to GLP-1 receptors causing an increase of insulin secretion, reduce glucagon secretion, delay gastric emptying and appetite suppression Association with pancreatitis and can cause gastrointestinal side effects. Should be avoided in deteriorating renal function. Bile Acid Sequestrants Oral The mechanism is still uncertain. It is thought that this drug interferes with the enterohepatic circulation of bile acids to lessen their effect; increasing glucose metabolism and advance GLP-1 secretion Association with gastro intestinal disorders and elevated triglyceride levels. 3.1 Metformin This is the preferred first-line drug choice to treat Type 2 Diabetes Mellitus. This drug is part of the biguanide class and its main role is to reduce and maintain blood glucose levels without the risk of hypoglycaemia (extremely low blood glucose levels) and weight gain (Chatterjee 2015). It reduces glucose levels by suppressing hepatic glucose output and increasing insulin sensitivity in muscle cells (Bailey 2015). This drug can be used with used alone, but may be more effective when used in combination with other diabetes therapies, such as DPP-IV inhibitors, sulfonylureas and insulin. (Chatterjee 2015) (Ahren 2008). 3.2 Sulfonylureas This drug stimulates the secretion of insulin from pancreatic β-cells, by binding to the sulfonyurea receptor subunit of ATP sensitive potassium channel, closing it (Prors 2002). This closure causes depolarisation of the membrane, producing an influx of calcium, activating insulin secretion (Bailey 2015). This drug can only work correctly depending on sufficient β-cell function within the pancreas to assist in the release of more insulin (Bailey 2015). 3.3 DPP-IV Inhibitors This drug functions by inhibiting the action of enzyme DPP-IV from breaking down incretin hormones, in particular GLP-1. Prolonging the life of the incretin hormone allows it to perform its role and stimulate insulin secretion of the pancreatic β-cells (Seino 2010). 3.4 Sodium Glucose Transporter-2 (SGLT-2) Inhibitors SGLT-2 proteins present in the proximal convoluted tubule of the kidney are responsible for renal glucose filtration and reabsorption (Rizos and Elisaf 2013). Inhibitors of SGLT-2 competitively bind to and block the proteins reducing the amount of glucose reabsorption in the blood but increasing the amount of glucose excreted in urine (Bailey 2015). Associated with the elimination of glucose in urine, the use SGLT-2 inhibitors increase the risk of genital and urinary tract infections (Bailey 2015). 3.5 GLP-1 MIMETICS 3.6 Bile Acid Sequestrants Bile acids are produced in the liver and upon release promote the absorption of fatty acids (Hansen 2014). However, it has been found that bile acids are associated with the regulation of glucose homeostasis (Nguyen 2008). The exact mechanism of the bile acids sequestrants is unknown, but it has been investigated that this drug inhibits the binding of bile acids to the corresponding receptors, TGR5 and Farnesoid-X-receptor (FXR) interrupting the enterohepatic bile acid circulation and increasing the utilisation of glucose. (Hansen 2014) (Bailey 2015). ?5.0 Combination Treatment Therapy More recently combination drug therapy has been analysed and proved to have beneficial effects in rodents, such as GLP-1-GIP-GCG triple incretin agonists (Gault 2013). 4.0 Gut Peptides The intake of food generates the release of two primary incretin hormones; Gastric inhibitory polypeptide (GIP) and Glucagon-like peptide (GLP-1) (Seino et al 2010). Secreted from the intestinal K-cells and L-cells respectively (Bailey 2015), these hormones are released to stimulate insulin secretion to aid in glycaemic control and have a positive effect on the survival of β-cells (Brubaker 2006). 4.2 GLP-1 This 31 amino acid hormone chain, not only inhibits glucagon release and stimulates insulin secretion, also has been discovered in the Central Nervous System promoting satiety (Seino et al 2010) (Gallwitz 2005). GLP-1 agonists are more recently used as peptide drug to treat type 2 diabetes mellitus (Fosgerau 2015). 5.0 Neurotensin A neuropeptide secreted from endocrine cells in the gastrointestinal tract, was found to have two important roles in glycaemic control by increasing the release of insulin in low glucose concentrations and decreasing the release of glucose-mediated insulin (Gruundal et al 2016) (Béraud-Dufour 2010). Neurotensin also functions to protect the pancreatic β-cells from apoptosis in patients with Type 2 diabetes (Mazella 2012). 6.0 Xenin Xenin, a 25 amino acid gut peptide derived from the K-cells in the small intestine (Wice et al 2012). This peptide was initially identified in the human gastric mucosa, and it was further discovered in the liver, pancreas, hypothalamus and stomach (Parthsarthy 2016). It is co-secreted from the K-cells along with GIP following the consumption of high-fat meal increasing the concentration of this peptide in the plasma (Martin et al 2012) (Wice 2012). Natural occurring xenin has been known to have a restricted therapeutic effect due to break down by plasma enzymes (Martin et al 2016). A hybrid peptide Xenin-25(gln) was generated by substituting Arginine and Lysine amino acids present on natural Xenin-25 with Glutamine (Parthsarthy et al 2016). 8.0 Modified gut peptide Hybrid peptides have been generated via fusion of vital sequences in amino acid chains (Hasib et al 2016). These modified peptides increase the therapeutic ability of antidiabetic drugs, which can be given in one drug combined, rather than separate forms (Hasib 2016). Recent studies assessing the therapeutic activity of the hybrid peptide xenin-8-gln, in the treatment of Type 2 diabetes (Hasib et al 2016) compared to constituent parent peptides, indicate a potential for the use of hybrid peptides in the treatment of diabetes. 9.BRIN BD11 Cells Electrofusion of rat pancreatic islet cells and RINm5F cells produced a hybrid cell line known as BRIN-BD11 cells (McClenaghan et al 1996) (Davies et al 2000). It was found that this cell line had similar properties and responses when compared to normal β-cells (Davies et al 2000). 10.0 Conclusion Recent research has demonstrated that new therapeutic treatments are needed as the incidence type 2 diabetes mellitus is increasing globally. Hybrid peptides are becoming more popular in the field of diabetes treatment. By generating a long acting modified peptide (Q8Q9W11) neurotensin-K6-L-glutamyl-PAL it will be investigated how effective it will be at stimulating insulin secretion compared to non-acetylated constituent peptides. This modified peptide, along with control peptide counterparts will be commercially synthesised and purified using HPLC. The insulin secreting properties of the modified peptide will be measured, recorded and analysed at various glucose concentrations within BRINBD-11 cells. This could further develop treatment for type 2 diabetes. References Ahrén, B. (2008b) ‘Novel combination treatment of type 2 diabetes DPP-4 inhibition metformin’, Vascular Health and Risk Management, 4(2), pp. 383-394. Bacha, F. and Klinepeter Bartz, S. (2015) ‘Insulin resistance, role of metformin and other non-insulin therapies in pediatric type 1 diabetes’, Pediatric Diabetes, , p. n/a-n/a. doi: 10.1111/pedi.12337. Bailey, C. (2015) ‘The current drug treatment landscape for diabetes and perspectives for the future’, Clinical Pharmacology

Bellevue University Lowes Home Improvement Center Question

i need help writing an essay Bellevue University Lowes Home Improvement Center Question.

I’m working on a business report and need support to help me study.

Your attention has been focused on how merchants use consumer analysis and demographics to help ensure that the right products are targeted to specific consumers. As a result of using these tools, products can be ordered and delivered to the right stores as efficiently and effectively as possible. Studying demographics includes considering a wide variety of differentiators. For this assignment, you are going to research and work with several demographic characteristics to analyze a specific region or marketInstructions:One way that merchants obtain demographic information is to search for information using a zip code or codes. There are many websites that provide free demographic information when you enter a zip code. (e.g. – Esri Zip Code Lookup; ZIP code Look-up – PRIZM; ZipWho.com; etc.)Choose two different websites as described above to research the demographics of the zip codes within a 5-mile radius of the Lowe’s Home Improvement Center located at 3001 Battleground Avenue, Greensboro, NC 27408.Breakdown the demographic patterns using at least six demographic characteristics described in this week’s content.Present the information you gather in an Excel spreadsheet or a table. Reference the spreadsheet or table within your paper and include it in an appendix.Using the information gathered in the part 1 of the instructions and additional research:Research the store’s product selection by visiting the store’s website (https://www.lowes.com/store/NC-Greensboro/0387?cm_… _-0 ), clicking on the “Departments” tab at the top of the web page, and choosing one or more departments (appliances, tools, flooring, home services, kitchen, etc.). Take a position on how well the company’s merchandise/product strategy is meeting the needs of the population within the 5-mile radius you studied. Justify your position with at least three examples that illustrate how population needs are being met.Form conclusions about whether the company’s strategy will successfully increase its market share within the study area. Support your conclusions with specific examples or research findings.Explain why it is important for the company to view its merchandise/product strategy as an integrated and ongoing process.Include a discussion of the relationships among the store’s merchandise/product strategy, the organization’s merchandise/product strategy, and the organization’s overall business strategy.Write a four-page paper (minimum) that thoroughly addresses all of the areas included in the instructions. The minimum length does not include the title page, abstract, reference page, or any additional pages containing charts, appendices, etc. Cite a minimum of two outside sources used in your research. You must give appropriate credit to the sources of the material, both external and internal.
Bellevue University Lowes Home Improvement Center Question

Why I Wish To Pursue A Career in Aviation?

Why I Wish To Pursue A Career in Aviation?. I’m stuck on a Writing question and need an explanation.

350 word minimum/500 word maximum double spaced essay stating “Why I Wish to Pursue a Career in Aviation”
I am a High School senior in Southside, Virginia. I have been accepted to Liberty University for Fall 2020. I plan to major in Military Aeronautics and in participate in the Air Force ROTC. I wish to come out commissioned into the United States Air Force as a pilot. I have always wanted to serve in the Air Force as my father did, I have also always wanted to fly as I am already at 17 currently obtaining my private pilots license with approximately 10 hours under my belt. I love to explore and experience new things hence this path I wish to take with my future.
Why I Wish To Pursue A Career in Aviation?

Lone Star College Time Is Not Linear by An My Le Discussion

Lone Star College Time Is Not Linear by An My Le Discussion.

I have attached the essay outline and artist research below. You don’t have to follow the outline completely that just there to help you. Topic: Time is not linearArtist: An-My LeLength: 4-6 pagesPlease read the instruction carefullyEssay objective (creative question or statement): Consider the argument you want to make regarding the human experience and maintaining a creative practice.To help you decide on a topic ask yourself a few questions regarding the research you have done this semester:What does it mean to live a creative life?Are the systems around you important to your creative pursuits?Has collecting, either your own or that of others, affected you in some way?How can you curate a creative practice?How does cultural humility play a role in living a creative life? What symbols present themselves in your research?Your essay should include each of the sections listed below. Apart from the Introduction, conclusion and sources, they can be in whatever order you choose.IntroductionHook sentence – What will we be exploring in your essay?What is the overall idea based on the arguments to follow?Readings – You will be required to present one main idea from the research you have done throughout the semester.Summary of the main points from you research. Whether you use quotes or paraphrase – do not copy and paste and make sure to use in-text citations when necessary.Do you agree/disagree? Why?What questions present themselves based on your research, both from the course and individually?How can you connect to culture and the human experience?Artist(s) – You are required to choose at least one (1) artist, and to have at least one (2) sources for them (not including any provided by me on Canvas). Your main idea should connect to the artist or collective you chose.What artist did you choose?Did you focus on a specific piece or collection that they created?Conceptual interpretation of their work(s).What are other writings or resources available on this artist and their work or this piece in particular.What questions present themselves for creative research based on the artwork?Speculative – You will be required to present one main idea in response to your research that will be explored in your final making-based project. Your Final Creative Project should be directly connected to this.How can you connect your creative question or statement to your intended creative project?What are you considering making?ConclusionRestate your overall idea.End with a provocative statement or question to set up your making-based project.Your essay should use MLA formatting and must be a minimum of four (4) pages typewritten (max 6), double spaced, 12 pt. Include your name and section number on the first page
Lone Star College Time Is Not Linear by An My Le Discussion

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