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A tourism development plan for a specific type of tourism

A tourism development plan for a specific type of tourism. I’m studying for my Writing class and need an explanation.

You have been hired as a consultant to develop a tourism development plan for a specific type of tourism (heritage, adventure, beach, etc.) in a specific country or region (you will select the country/region you want to work on). The plan should be treated as if it will be submitted at a later stage to an international funding agency such as the World Bank for consideration for funding. In your plan you need to provide 1) a brief introductory background to your selected country/region, 2) a detailed plan of your development/strategy proposal strongly linked to the literature on planning and development and to your selected type of tourism and 3) a conclusion with recommendations and challenges associated with moving forward with the proposed development.
A tourism development plan for a specific type of tourism

BIO102 Virginia Community Ancient DNA From Roman and Medieval Grape Article.

Directions:Visit the EurekAlert! Science News website at https://www.eurekalert.org. Choose an article of interest to you that was published within the last 6 months. Review the article and answer the following questions:Provide the hyperlink to your article and the title of the article here (4 points):In 3-5 sentences, explain what the article is about (e.g. piece of research, discovery, or a scientist’s statement). Also elaborate here if parts of the Scientific Method are outlined in the news article (e.g. independent variable, dependent variable, control, etc.) (6 points)Where did the story come from (which country and which sort of organization) (2 points)Who did the journalist quote (e.g. scientists or politicians), if anyone? Where are they from? (2 points)By examining the news’ report, is it possible to tell who funded the research? If this information cannot be found in the text, why do you think it is not there? Do you have any concerns about who funded the study? (4 points)Has the topic of the report been published in a peer-reviewed scientific journal? If so, which one? Do you think this information is important? Why or why not? (4 points)Were you familiar with the subject before reading the story? If you were, does the text contain new information for you? What, if anything, conflicts with what you knew or thought before? Please elaborate here with 3-5 sentences. (6 points)Who do you think this text was written for (e.g. students, teachers, researchers or the general public)? What makes you think that? (2 points)What was the journalist’s / newspaper’s aim in writing / publishing this article? Purely to provide information? Or is there an ulterior motive, such as scaremongering, a political aim, or trying to sell more newspapers? (4 points)What did you learn by completing this assignment regarding the interpretation of scientific concepts in news articles? Do you have concerns about what was written in the article you chose? (4 points)
BIO102 Virginia Community Ancient DNA From Roman and Medieval Grape Article

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Paper feedback. Paper details I want a strategic development and expansion plan for Family medicine Academy to increase Training Seat Capacity in the Family Medicine Board Programme without affecting quality. Maximum Annual Training Seats Capacity to reach 100 within 3 years starting with 42 Trainees. Training Instructure, Manpower, External Clinical Rotations, etc. should be factored in. Attached files will be more beneficial to clear out the picture for you. Thank youPaper feedback

LIT SNHU Wk 3 Doll House and Hamlet Drama Novel Discussion

custom writing service LIT SNHU Wk 3 Doll House and Hamlet Drama Novel Discussion.

The info below is for reference but the two post are attached. –If you cite a sentence or more from a source then cite the source. If you do not, you are committing plagiarism.–Keep the meanings of denotative and connotative in mind. Denotative refers to the literal meaning; connotative means suggesting a meaning that is more than or beyond the literal meaning of a word, phrase, image, symbol, and so on.000000000000Option 1What is a theme or issue we can see in the play Hamlet, Prince of Denmark? What do you think Shakespeare is saying about that issue? Please explain using some specifics from the play. Can you see that issue in today’s society? Please explain.—Look at the discussion of theme in Chapter 6 and at the discussion of ELEMENTS OF PLAY in Chapter 35, and at the discussion in “Reading a Story” in Chapter 1.Option 5Read Ibsen’s play A Doll’s House then summarize it for us in a paragraph of no more than three sentences. In another paragraph, explain what you think is the theme of the play and what you think Ibsen is saying about the issue of the theme. Use details from the play to support your caims.—Look at the discussion of theme in Chapter 6 and at the discussion of ELEMENTS OF PLAY in Chapter 35, and at the discussion in “Reading a Story” in Chapter 1.
LIT SNHU Wk 3 Doll House and Hamlet Drama Novel Discussion

GCCCD Job Application Online Memorandum

GCCCD Job Application Online Memorandum.

One of the most effective tools for a job hunting is the ability to “Network”. This assignment is all about that. Attend 3 Networking events such a Chamber of Commerce or Industry event.Provide documentation of your attendance i.e. Business Cards, Event Brochure, and write a brief description on the value of the event. Prepare a brief memo to answer the following questions.Did you pick up some good information?Did you make some valuable contacts?Would you recommend it to other Students?Submit all 3 events as a PDF via Canvas. Remember events must be verifiable and include answer to the questions to receive credit.
GCCCD Job Application Online Memorandum

Loss of Brain Nerve Cells in Alzheimer’s Disease

Fig-6: Showing neuronal death due to inflammation and oxidative stress. Adenosine Deaminase (ADA), and Neuropsychiatric Disorders:- Adenosine is a neuromodulator of brain function that is uniquely positioned to integrate excitatory and inhibitory neurotransmission and neuroprotective actions in pathological conditions. The understanding of adenosine production and release in the brain is therefore of fundamental importance and has been extensively studied (ADA-8). Adenosine metabolism in the brain is very important, and its dysregulation has been implicated in pathophysiology of several neuropsychiatric disorders, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine (ADA-7). (The production and metabolism of adenosine is given in the Fig.7) Adenosine deaminase (ADA, adenosine aminohydrolase, EC 3.5.4.4), an enzyme involved in the metabolism of purine nucleosides, catalyses the irreversible hydrolytic deamination of adenosine (Ado) and 2´-deoxyadenosine (2´-dAdo) to inosine and 2´- deoxyinosine, respectively. The enzyme is widely distributed in vertebrate tissues and plays a critical role in a number of physiological systems. In nature, several isoforms of ADA are known that differ by molecular mass, kinetic properties and tissue distribution (ADA-2). It plays a role in the development and functioning of T lymphomonocytes. Levels of this enzyme increase during the mitogenic and antigenic response of lymphocytes, whereas ADA inhibitors limited the blastogenesis of lymphocytes; thus, ADA levels are higher in T cells than in B lymphocytes. ADA was previously recognized as a cytosolic enzyme; however, it is currently known to be present at the surfaces of cells, in particular T lymphocytes, to interact with some membrane proteins, including CD-26/DPP IV, and is considered an ecto-enzyme. This co-localization of DPP IV/CD-26 and ADA at T cells is important for the activation of T cells because the interaction of ADA and CD-26 at the T cells results in co-stimulatory signs responsible for the activation of the T cell receptor (ada ). Long considered to be an immune-privileged site because of the presence of the blood-brain-barrier (BBB) and the lack of a lymphatic system, it is now well-established that the brain is fully capable of mounting inflammatory responses in response to invading pathogens, trauma, or ischemic events (G-17). Fig. 7 Pathways of adenosine production, metabolism and transport, with indications of the sites of action of various enzyme inhibitors. Abbreviations are as follows: ADA, adenosine deaminase; AK, adenosine kinase; AOPCP, a,b-methylene ADP; DCF, deoxycoformycin; EHNA, erythro-9-(2-hydroxy-3-nonyl)adenosine; es, equilibrativesensitive nucleoside transporters; ei, equilibrative- insensitive nucleoside transporters; 5-IT, 5-iodotubercidin; NBMPR, nitrobenzylthioinosine; PDE, cAMP phosphodiesterase; SAH, S-adenosyl homocysteine. Activation of oligodendrocytes results in secretion of inflammatory molecules, such as nitric oxide (NO), cytokines, and prostaglandins and most notably in upregulation of several chondroitin sulfate proteoglycans, including NG2, which contributes to the growth-inhibitory environment that prevents regeneration of axons in the injured CNS. In summary, in acute situations and when short lived, neuro-inflammatory mechanisms generally limit injury and promote healing; however, when neuro-inflammation becomes chronic it can damage viable host tissue, resulting in compromised neuronal survival and cognitive impairment. For these reasons, inflammation in the CNS has been appropriately described as a two-edged sword (G-17). Again Hcy activates cytokines and pro-inflammatory molecules, such as IL-1beta, IL-6, IL-12, IL-18, IL- 1 receptor antagonist, C-reactive protein, adhesion molecules (P-selectin, E-selectin, ICAM-1), and metalloproteinases (MMP-9). In addition, Hcy up-regulates reactive oxygen species, leading to activation of NF-kappa B, the pro-inflammatory nuclear regulatory molecule (G-3). On the other hand, neuropsychiatric disorders have been shown to be accompanied with some immune-inflammatory alterations. In this regard in order to make a contribution to the understanding of the ongoing immune disturbance in neuropsychiatric disorders, serum ADA activity was determined in neuropsychiatric patients and compared with healthy controls. Intracellular and extracellular levels of adenosine are tightly controlled by specific nucleoside transporters and several important enzymes, which include adenosine deaminase (ADA) and 5’-nucleotidase (5’-NT) (ADA-4). ADA activity is known to be increased in inflammatory diseases characterized by T-cell activation and proliferation. Therefore, ADA is considered a marker of T-cell activation. In addition, overproduction of reactive oxygen species (ROS) including hydrogen peroxide (H2O2), superoxide anion (Oâ-_ 2); nitric oxide (NOâ-) and singlet oxygen (1O2) creates a condition known as oxidative stress, resulting in the amplification of the inflammatory response (ADA-6). Studies related to ADA levels in neuropsychiatric patients are virtually non-existent. ADA and schizophrenia Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin etc. Dutra GD et al (2009) showed that decreased ADA activity in schizophrenic patients than in control subjects (ADA-7). Brunstein MG et al (2007) reported that the schizophrenic patients treated either with typical antipsychotics or clozapine showed increased serum ADA activity compared to controls (ada-b sub 14). ADA and Depression Elgun et al (1999b) reported that decrease ADA activity in patients with depression compared with controls, might reflect the impaired immune system in depression (A sub). Mackiewicz et al (2006) showed that ADA levels did not change with age in rats (A sub). Herken H et al (2007) showed that ADA levels of the patients were significantly higher than the controls (abstract ref). An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimer’s disease (A-9). Inflammation is a cause, contributor, or secondary phenomenon in the disorder inflammatory pathways are altered in the periphery in AD, together with evidence that increased peripheral inflammation leads to more neurodegeneration and accelerated disease progression in animal models. Antioxidants defense:- Humans have evolved a highly complicated antioxidant defense system to combat the damaging effects of free radicals. Under physiological conditions, overproduction of ROS and RNS and their neutralization is prevented by the activity of endogenous anti-oxidative defense system (AOS). Antioxidants are a broad group of compounds which constitute the first line of defense against free radical damage thus are essential for maintaining optimum health and well-being. They are protective agents, capable of stabilizing or deactivating free radicals before they attack cells. Being beneficial compounds, they control free radical formation naturally and help organisms to deal with oxidative stress caused by free radicals (antiox 4) (Fig. 8). Antioxidant system encloses enzymes like superoxide dismutase; catalase, glutathione peroxidase, and other antioxidant-regenerating enzymes such as gluthatione reductase; dehydroascorbate reductase and glucose-6 phosphate dehydrogenase, that maintains reduced NADPH; hydrophilic scavengers like urate, ascorbate, gluthatione, flavonoids; lipophilic scavengers, like tocopherols, carotenoids and ubiquinone. The great majority of antioxidants are supplied with the diet and includes polyphenols, lipoic and ascorbic acid, carotenoids, lycopene, quercetine, genstein, ellagic acid, ubiquinone and indole-3 carbinole. In fact, in the biological systems, the normal processes of oxidation produces highly reactive free radicals and each of this administered compounds is involved in the physiological redox balance preventing damage to the tissues (antioxi 3). Enzymatic Antioxidants An important part of the intracellular antioxidant defense systems are antioxidant enzymes such as superoxide dismutase, catalase and peroxidases. Superoxide dismutase (SOD) SOD is found abundantly in many organisms, from microorganisms to plant and animals, since superoxide radicals (O2−•) are toxic to living cells, oxidizing and degrading biologically important molecules, such as lipids and proteins. The role of SOD is to protect aerobic cells against O2−• action. It catalyzes O2−• dismutation reaction into H2O2 and O2−•. There are three known types of SOD: two copper-zinc containing SOD (CuZn-SOD), one in cytosol and one bound to the vascular endothelium ( also called “extracellular SOD” (ECSOD)) and a manganese containing SOD (MnSOD), which is localized in the mitochondrial matrix (antio-4). This enzyme specifically catalyzes the dismutation of O2−• anion into H2O2 and O2−• in a pH-independent medium (5–9.5). Manganese SOD is the mitochondrial form of this dismutase. Its active site contains manganese and reduces the O2−• generated during the ETC. The amount of MnSOD inside the cell varies according to the number of mitochondria found in each cell type. This enzyme has antitumor activity. Extracellular SOD also contains copper and zinc in its structure and is the main extracellular SOD. It is synthesized inside the cells and secreted into the extracellular matrix (G-66, G-71, SOD-1). Fig. 8- Mechanism of action of antioxidants Catalase (CAT) Catalase is an enzyme that reacts very effectively with H2O2 to form water and molecular oxygen and with H donors (methanol, ethanol, formic acid, or phenols) with peroxidase activity. Catalase protects cells against H2O2 generated inside them. Although CAT is not essential to some cell types under normal conditions, it has an important role in the acquisition of tolerance to O